| Paint It Black | 2016 | Director | Director |
| Paint It Black | 2016 | Writer | writer |
| The Gynotician | 2013 | Writer | co-writer |
| You Hurt My Feelings | 2023 | Actress | Carolyn |
| Inside Amy Schumer | 2013–2022 | Actress | The Teacher |
| Y: The Last Man | 2021 | Actress | Kimberly Campbell Cunningham |
| Helpsters | 2019 | Actress | Paleontologist Paloma |
| Drunk History | 2018 | Actress | Margaret Sanger |
| Nostalgia | 2018 | Actress | Bethany |
| Girlfriend's Day | 2017 | Actress | Jill |
| The Increasingly Poor Decisions of Todd Margaret | 2009–2016 | Actress | Stephanie Daley |
| The Heyday of the Insensitive Bastards | 2015 | Actress | Amanda |
| Two and a Half Men | 2013–2015 | Actress | Jenny Harper |
| Almost Not Beautiful | 2014 | Actress | Amanda |
| Growing Up and Other Lies | 2014 | Actress | Tabatha |
| X/Y | 2014 | Actress | Stacey |
| Community | 2014 | Actress | Thought Jacker Co-Star (uncredited) |
| 3 Nights in the Desert | 2014 | Actress | Anna |
| The Heart, She Holler | 2013 | Actress | Hurlette Headhe |
| Anatomy of Violence | 2013 | Actress | Abby Ravner |
| Django Unchained | 2012 | Actress | Daughter of a Son of a Gunfighter |
| House | 2010–2012 | Actress | Martha M. Masters |
| Metalocalypse | 2012 | Actress | Trindle (voice) |
| Portlandia | 2012 | Actress | Intern |
| 127 Hours: Deleted Scenes | 2011 | Actress | Megan |
| The Quinn-tuplets | 2010 | Actress | Miriam Quinn |
| Main Street | 2010 | Actress | Mary Saunders |
| 127 Hours | 2010 | Actress | Megan |
| Comedy Showcase | 2009 | Actress | Girl |
| Beyond a Reasonable Doubt | 2009 | Actress | Ella Crystal |
| The Unusuals | 2009 | Actress | Detective Casey Shraeger |
| Spring Breakdown | 2009 | Actress | Ashley Hartmann |
| The Sisterhood of the Traveling Pants 2 | 2008 | Actress | Tibby Tomko-Rollins |
| Blackout | 2008 | Actress | Claudia |
| The Russell Girl | 2008 | Actress | Sarah Russell |
| Babylon Fields | 2007 | Actress | Janine Wunch |
| Normal Adolescent Behavior | 2007 | Actress | Wendy |
| Spiral | 2007 | Actress | Amber |
| The Grudge 2 | 2006 | Actress | Aubrey |
| Stephanie Daley | 2006 | Actress | Stephanie Daley |
| The Sisterhood of the Traveling Pants | 2005 | Actress | Tibby |
| I'm Still Here: Real Diaries of Young People Who Lived During the Holocaust | 2005 | Actress | Elizabeth Kaugmann |
| Joan of Arcadia | 2003–2005 | Actress | Joan Girardi |
| Without a Trace | 2003 | Actress | Clare Metcalf |
| Prep | 2002 | Actress | |
| CSI: Miami | 2002 | Actress | Senior Cadet Valerie Barreiro |
| The Ring | 2002 | Actress | Katie |
| The Twilight Zone | 2002 | Actress | Jenna Winslow |
| Ten Minutes Older: The Trumpet | 2002 | Actress | Kate (segment "Twelve Miles to Trona") |
| Boston Public | 2002 | Actress | Melissa Campbell |
| Buffy the Vampire Slayer | 2001 | Actress | Janice Penshaw |
| General Hospital | 1995–2001 | Actress | Emily Quartermaine |
| Port Charles | 1999–2000 | Actress | Emily Bowen Quartermaine |
| Johnny Mysto: Boy Wizard | 1997 | Actress | Sprout |
| Rebellious | 1995 | Actress | Deb |
| Live Nude Girls | 1995 | Actress | Young Jill (as Amber Rose Tamblyn) |
| Paint It Black | 2016 | Producer | producer |
| The Gynotician | 2013 | Producer | executive producer |
| You Belong Everywhere: Portrait of a Living Poet | 2011 | Producer | executive producer |
| The Drums Inside Your Chest | 2009 | Producer | executive producer |
| David Cross: Oh Come On | 2019 | Thanks | extra extra triple special thanks |
| David Cross: Making America Great Again | 2016 | Thanks | special thanks |
| Super | 2010 | Thanks | special thanks |
| Real Medicine Foundation in Turkana Kenya Short | 2010 | Thanks | thanks |
| Meltdown | 2009 | Thanks | special thanks |
| What Goes Up | 2009 | Thanks | special thanks |
| The View | 2004–2024 | Self | Self |
| General Hospital: 60 Years of Stars and Storytelling | 2024 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2017–2022 | Self | Self - Guest |
| The Social | 2022 | Self | Self - Guest Panelist & Author |
| CBS Mornings | 2022 | Self | Self |
| Reframed: Marilyn Monroe | 2022 | Self | Self - Author, Actor and Director |
| CNN New Year's Eve Live with Anderson Cooper & Andy Cohen | 2021 | Self | Self |
| Moms Don't Have Time to Read Books Podcast Series | 2020 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2018–2020 | Self | Self - Guest |
| Late Night with Seth Meyers Podcast | 2020 | Self | Self - Guest |
| Late Night with Seth Meyers | 2020 | Self | Self - Guest |
| Today | 2005–2019 | Self | Self - Guest |
| The Late Show with Stephen Colbert | 2019 | Self | Self - Guest |
| CTV News at Six Toronto | 2018 | Self | Self |
| Front Row Flynn | 2018 | Self | Self |
| This Changes Everything | 2018 | Self | Self |
| CBS News Sunday Morning with Jane Pauley | 2018 | Self | Self |
| Citizen Rose | 2018 | Self | Self |
| Full Frontal with Samantha Bee | 2018 | Self | Self - Musical Guest |
| The 11th Annual CNN Heroes: An All-Star Tribute TV Special | 2017 | Self | Self - Presenter |
| Lip Sync Battle | 2016 | Self | Self - Competitor |
| Lip Sync Battle Preshow | 2016 | Self | Self |
| Inside Amy Schumer | 2016 | Self | Self |
| Modern Love Podcast Series | 2016 | Self | Self - Narrator |
| Hollywood Ever After: Amber Tamblyn on Poetry and Death Short | 2015 | Self | Amber Tamblyn |
| Park Bench with Steve Buscemi | 2015 | Self | Self |
| WTF with Marc Maron | 2015 | Self | Self - Guest |
| Comedy Bang! Bang! | 2014 | Self | Self |
| The Talk | 2014 | Self | Self - Guest |
| 71st Golden Globe Awards | 2014 | Self | Self (uncredited) |
| Live with Kelly and Mark | 2005–2013 | Self | Self - Guest |
| The Gynotician | 2013 | Self | Woman |
| This One Time TV Series | 2013 | Self | Self |
| The 2011 Independent Spirit Awards | 2011 | Self | Self |
| Real Medicine Foundation in Turkana Kenya Short | 2010 | Self | |
| Whatever Happened To? | 2010 | Self | Self |
| Late Night with Jimmy Fallon | 2009 | Self | Self - Guest |
| The Drums Inside Your Chest | 2009 | Self | Self |
| Entertainment Tonight | 2006–2009 | Self | Self |
| Good Morning America | 2008 | Self | Self - Guest |
| One Fast Move or I'm Gone: Kerouac's Big Sur | 2008 | Self | Self |
| The Making of 'Spiral' | 2008 | Self | Self |
| 2007 Much Music Video Music Awards | 2007 | Self | Self |
| Up Close with Carrie Keagan | 2007 | Self | Self - Guest |
| Shootout | 2007 | Self | Self |
| The Grudge 2: Ready When You Are Mr Shimizu | 2007 | Self | Self |
| The Grudge 2: Holding a Grudge | 2007 | Self | |
| Film Independent's 2007 Spirit Awards | 2007 | Self | Self - Nominee |
| Storyline Online | 2006 | Self | Self |
| HypaSpace | 2006 | Self | Self |
| The Ellen DeGeneres Show | 2006 | Self | Self - Guest |
| Fuse Celebrity Playlist | 2006 | Self | Self - Guest |
| The 63rd Annual Golden Globe Awards 2006 | 2006 | Self | Self |
| Young Hollywood Awards | 2005 | Self | Self |
| The Tony Danza Show | 2005 | Self | Self - Guest |
| Celebrity Poker Showdown | 2005 | Self | Self |
| Fashion News Live | 2005 | Self | Self |
| The Teen Choice Awards 2005 | 2005 | Self | Self - Attendee |
| The Tonight Show with Jay Leno | 2005 | Self | Self - Guest |
| Total Request Live | 2004–2005 | Self | Self |
| Late Night with Conan O'Brien | 2005 | Self | Self - Guest |
| Mad TV | 2005 | Self | Self |
| The Late Late Show with Craig Ferguson | 2005 | Self | Self - Guest |
| Nickelodeon Kids' Choice Awards '05 | 2005 | Self | Self |
| CBS Cares | 2004–2005 | Self | Self |
| The 6th Annual Family Television Awards | 2004 | Self | Self |
| The 56th Annual Primetime Emmy Awards | 2004 | Self | Self |
| Life & Style | 2004 | Self | Self |
| The 5th Annual Latin Grammy Awards TV Special | 2004 | Self | Self - Presenter |
| The Sharon Osbourne Show | 2004 | Self | Self - Guest |
| A Tribute to Joe Mantegna | 2004 | Self | Self |
| The Wayne Brady Show | 2004 | Self | Self - Guest |
| 10th Annual Screen Actors Guild Awards | 2004 | Self | Self - Presenter |
| Late Show with David Letterman | 2004 | Self | Self - Guest |
| The 46th Annual Grammy Awards | 2004 | Self | Self - Presenter |
| The 61st Annual Golden Globe Awards | 2004 | Self | Self |
| The 30th Annual People's Choice Awards | 2004 | Self | Self |
| Punk'd | 2003 | Self | Self |
| Postcards from the Cast | 2001 | Self | Self (uncredited) |
| Entertainment Tonight | 2020 | Archive Footage | Self (archive footage) |
| Missing Persons | 1993–1995 | Archive Footage | (archive footage) |