| The Handmaid's Tale | 2021–2025 | Director | Director |
| Shining Girls | 2022 | Director | Director |
| The Handmaid's Tale | 2017–2025 | Actress | June Osborne |
| Shell | 2024 | Actress | Samantha Lake |
| The Veil | 2024 | Actress | Imogen Salter |
| Next Goal Wins | 2023 | Actress | Gail |
| Shining Girls | 2022 | Actress | Kirby Mazrachi |
| The French Dispatch | 2021 | Actress | Alumna |
| The Invisible Man | 2020 | Actress | Cecilia Kass |
| Shirley | 2020 | Actress | Shirley Jackson |
| The Kitchen | 2019 | Actress | Claire Walsh |
| Us | 2019 | Actress | Kitty Tyler |
| Light of My Life | 2019 | Actress | Mom |
| Brandi Carlile: Party of One | 2018 | Actress | Elisabeth Moss |
| Her Smell | 2018 | Actress | Becky Something |
| The Old Man & the Gun | 2018 | Actress | Dorothy |
| Max Richter: On the Nature of Daylight | 2018 | Actress | |
| The Seagull | 2018 | Actress | Masha |
| Top of the Lake | 2013–2017 | Actress | Robin Griffin |
| The Square | 2017 | Actress | Anne |
| Tokyo Project | 2017 | Actress | Claire |
| Mad to Be Normal | 2017 | Actress | Angie Wood |
| Chuck | 2016 | Actress | Phyliss Wepner |
| The Free World | 2016 | Actress | Doris Lamb |
| High-Rise | 2015 | Actress | Helen |
| Truth | 2015 | Actress | Lucy Scott |
| Mad Men | 2007–2015 | Actress | Peggy Olson |
| Meadowland | 2015 | Actress | Shannon |
| Queen of Earth | 2015 | Actress | Catherine |
| Couples Therapy | 2014 | Actress | Sophie |
| The One I Love | 2014 | Actress | Sophie |
| Listen Up Philip | 2014 | Actress | Ashley Kane |
| The Simpsons | 2013 | Actress | Gretchen (voice) |
| On the Road | 2012 | Actress | Galatea Dunkel |
| Razorback & Paisley TV Mini Series | 2012 | Actress | Special Agent Eva |
| Darling Companion | 2012 | Actress | Grace |
| Smoking Nonsmoking | 2011 | Actress | Diana Whelan |
| Green Lantern: Emerald Knights | 2011 | Actress | Arisia (voice) |
| A Buddy Story | 2010 | Actress | Susan Adams |
| Get Him to the Greek | 2010 | Actress | Daphne Binks |
| Did You Hear About the Morgans? | 2009 | Actress | Jackie Drake |
| Mercy | 2009 | Actress | Lucy Morton |
| The Pack | 2009 | Actress | Diana Whelan |
| Saturday Night Live | 2008 | Actress | Peggy Olson (uncredited) |
| Fear Itself | 2008 | Actress | Danny Bannerman |
| New Orleans, Mon Amour | 2008 | Actress | Hyde |
| El camino | 2008 | Actress | Lily |
| Ghost Whisperer | 2007 | Actress | Nikki Drake |
| The Attic | 2007 | Actress | Emma Callan |
| Honored | 2007 | Actress | Katie |
| Day Zero | 2007 | Actress | Patricia |
| Medium | 2007 | Actress | Jennie |
| They Never Found Her | 2007 | Actress | Anna |
| Grey's Anatomy | 2007 | Actress | Nina Rogerson |
| Law & Order: Criminal Intent | 2006 | Actress | Rebecca Colemar |
| The West Wing | 1999–2006 | Actress | Zoey Bartlet |
| Invasion | 2005–2006 | Actress | Christina |
| Bittersweet Place | 2005 | Actress | Paulie Schaffer |
| Law & Order: Trial by Jury | 2005 | Actress | Katie Nevins |
| The Missing | 2003 | Actress | Anne |
| The Practice | 2003 | Actress | Jessica Palmer (as Elizabeth Moss) |
| Virgin | 2003 | Actress | Jessie Reynolds |
| Temptation | 2003 | Actress | Wind |
| Heart of America | 2002 | Actress | Robin Walters |
| West of Here | 2002 | Actress | Cherise |
| Spirit | 2001 | Actress | Kelly O'Conner |
| Girl, Interrupted | 1999 | Actress | Polly |
| Anywhere But Here | 1999 | Actress | Rachel |
| Mumford | 1999 | Actress | Katie Brockett |
| The Joyriders | 1999 | Actress | Jodi |
| Earthly Possessions | 1999 | Actress | Mindy |
| Angelmaker | 1998 | Actress | Little Turcott |
| A Thousand Acres | 1997 | Actress | Linda |
| Freakazoid! | 1995 | Actress | Kathy |
| The Last Supper | 1995 | Actress | Jenny Tyler |
| Separate Lives | 1995 | Actress | Ronni Beckwith |
| Naomi & Wynonna: Love Can Build a Bridge | 1995 | Actress | Early-Teen Ashley Judd |
| Escape to Witch Mountain | 1995 | Actress | Anna |
| Picket Fences | 1992–1995 | Actress | Cynthia Parks |
| Imaginary Crimes | 1994 | Actress | Greta |
| Gypsy | 1993 | Actress | Baby Louise |
| Animaniacs | 1993 | Actress | Katrina (voice) |
| Frosty Returns | 1993 | Actress | Holly (voice) |
| Johnny Bago | 1993 | Actress | Agnes |
| Once Upon a Forest | 1993 | Actress | Michelle (voice, as Elizabeth Moss) |
| Recycle Rex | 1993 | Actress | (voice, as Elissabeth Moss) |
| Batman: The Animated Series | 1993 | Actress | Kimmy (voice, as Elizabeth Moss) |
| It's Spring Training, Charlie Brown! | 1992 | Actress | Girl Player (voice, as Elissabeth Moss) |
| Midnight's Child | 1992 | Actress | Christina (as Elissabeth Moss) |
| Anything But Love | 1991 | Actress | |
| Suburban Commando | 1991 | Actress | Little Girl |
| Prison Stories: Women on the Inside | 1991 | Actress | Little Molly (segment "Parole Board") |
| Lucky Chances | 1990 | Actress | Lucky - Age 6 |
| Bar Girls | 1990 | Actress | Robin |
| Chick Corea: Eternal Child Music Video | 1988 | Actress | Elisabeth Moss (uncredited) |
| The Handmaid's Tale | 2017–2025 | Producer | executive producer |
| Shell | 2024 | Producer | producer |
| The Veil | 2024 | Producer | executive producer |
| Shining Girls | 2022 | Producer | executive producer |
| Hive | 2021 | Producer | executive producer |
| Shirley | 2020 | Producer | producer |
| Light from Light | 2019 | Producer | producer (produced by) |
| Her Smell | 2018 | Producer | producer |
| Ballet Now | 2018 | Producer | executive producer |
| Max Richter: On the Nature of Daylight | 2018 | Producer | producer |
| Queen of Earth | 2015 | Producer | producer |
| Muffins Mean Yes | 2022 | Thanks | special thanks |
| Her Smell | 2018 | Soundtrack | performer: "Another Girl, Another Planet", "Pulled Down", "Because You're Young", "Garbage Dump", "Heaven", "Control", "Breathe" |
| The Handmaid's Tale | 2018 | Soundtrack | performer: "I'll be Your Mirror" |
| Top of the Lake | 2017 | Soundtrack | performer: "I've Got You Under my Skin" |
| The Missing | 2003 | Soundtrack | performer: "Frère Jacques" (uncredited) |
| Gypsy | 1993 | Soundtrack | performer: "May We Entertain You", "Baby June and Her Newsboys" |
| The Jennifer Hudson Show | 2024–2025 | Self | Self |
| The Kelly Clarkson Show | 2020–2025 | Self | Self - Guest |
| Access Hollywood | 2019–2025 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2013–2025 | Self | Self - Guest |
| Live with Kelly and Mark | 2013–2025 | Self | Self |
| Good Morning America | 2019–2025 | Self | Self - Guest |
| Entertainment Tonight | 2008–2025 | Self | Self |
| Keep It Podcast Series | 2025 | Self | Self |
| Jimmy Kimmel Live! | 2013–2025 | Self | Self - Guest |
| FX Networks: YouTube Channel TV Series | 2024 | Self | Self |
| 92NY on NYC Life TV Mini Series | 2023 | Self | Self |
| Tamron Hall | 2023 | Self | Self |
| SmartLess | 2022 | Self | Self - Guest |
| Glamour: YouTube Channel TV Series | 2022 | Self | Self |
| The View | 2009–2022 | Self | Self |
| The Late Late Show with James Corden | 2017–2022 | Self | Self |
| In Creative Company | 2022 | Self | Self |
| The Drew Barrymore Show | 2022 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2021–2022 | Self | Self - Guest |
| CBS Mornings | 2022 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2017–2022 | Self | Self |
| Variety Studio: Actors on Actors | 2017–2021 | Self | Self |
| The Envelope: Emmy Roundtables TV Mini Series | 2021 | Self | Self |
| Late Night with Seth Meyers | 2015–2021 | Self | Self |
| Extra | 2017–2021 | Self | Self |
| The Critics' Choice Super Awards | 2021 | Self | Self - Winner |
| Sky News @Breakfast | 2020 | Self | Self - Actor |
| David Tennant Does a Podcast with... | 2020 | Self | Self (voice) |
| A West Wing Special to Benefit When We All Vote | 2020 | Self | Self |
| Hollywood First Look | 2020 | Self | Self |
| Soundtrack of Our Lives: A Celebration for the Film & TV Music Community TV Special | 2020 | Self | Self |
| Made in Hollywood | 2010–2020 | Self | Self |
| The Talk | 2020 | Self | Self |
| Director's Journey with Leigh Whannell | 2020 | Self | Self |
| AFI Movie Club | 2020 | Self | Self |
| Celebrity Page | 2017–2020 | Self | Self |
| Harper's Bazaar UK TV Series | 2020 | Self | Self |
| Hollywood Insider | 2020 | Self | Self |
| Late Night with Seth Meyers Podcast | 2020 | Self | Self - Guest |
| IMDbrief | 2020 | Self | Self - Guest |
| Días de cine | 2020 | Self | Self - Interviewee |
| GMA3: What You Need to Know | 2020 | Self | Self |
| IMDb Interviews | 2019–2020 | Self | Self - Guest |
| Collider Ladies Night | 2020 | Self | Self - Guest |
| El hormiguero | 2020 | Self | Self - Guest |
| C à vous | 2020 | Self | Self |
| 35th Film Independent Spirit Awards | 2020 | Self | Self - Nominee & Presenter |
| The 26th Annual Screen Actors Guild Awards | 2020 | Self | Self |
| Margaret Atwood: A Word After a Word After a Word Is Power | 2019 | Self | Self |
| Entertainment Tonight Canada | 2019 | Self | Self |
| Today | 2015–2019 | Self | Self - Guest |
| Red Carpet Report | 2019 | Self | Self |
| WGN Morning News | 2019 | Self | Self |
| 2019 MTV Movie & TV Awards | 2019 | Self | Self - Presenter & Winner |
| CBS Mornings | 2015–2019 | Self | Self |
| The Late Show with Stephen Colbert | 2017–2019 | Self | Self |
| The Ellen DeGeneres Show | 2014–2019 | Self | Self |
| The Big Picture | 2019 | Self | Self - Guest |
| Pop Quiz TV Series | 2019 | Self | Self |
| E! Live from the Red Carpet | 2014–2019 | Self | Self |
| 2019 Golden Globe Awards | 2019 | Self | Self - Nominee |
| Deadline Studio | 2018 | Self | Self |
| Variety Studio | 2013–2018 | Self | Self |
| The 70th Primetime Emmy Awards | 2018 | Self | Self - Nominee & Presenter |
| The Hollywood Reporter: Studio at Toronto TV Mini Series | 2018 | Self | Self |
| Close Up with the Hollywood Reporter | 2017–2018 | Self | Self |
| 24th Annual Screen Actors Guild Awards | 2018 | Self | Self - Nominee |
| 75th Golden Globe Awards | 2018 | Self | Self - Winner |
| Weekend Today | 2017 | Self | Self - Actress |
| In the Envelope: The Actor's Podcast Podcast Series | 2017 | Self | Self - Guest |
| 7th AACTA Awards TV Special | 2017 | Self | Self |
| Meet Elisabeth Moss on The Handmaid's Tale Set | 2017 | Self | Self |
| The 69th Primetime Emmy Awards | 2017 | Self | Self - Winner |
| Konbini | 2017 | Self | Self |
| The Insider | 2014–2017 | Self | Self |
| Chelsea | 2017 | Self | Self - Guest |
| Tria33 | 2017 | Self | Self - Interviewee |
| Off Camera with Sam Jones | 2017 | Self | Self |
| Tavis Smiley | 2013–2017 | Self | Self - Guest |
| Last Call with Carson Daly | 2017 | Self | Self - Guest |
| Celebrity Conversations | 2015 | Self | Self |
| The 67th Primetime Emmy Awards | 2015 | Self | Self - Nominee |
| Live from the Red Carpet: The 2015 Tony Awards TV Special | 2015 | Self | Self |
| The 69th Annual Tony Awards | 2015 | Self | Self - Nominee |
| Red Nose Day | 2015 | Self | Self |
| The Meredith Vieira Show | 2015 | Self | Self - Guest |
| SAG Foundation Conversations | 2015 | Self | Self |
| Talk Stoop | 2015 | Self | Self - Guest |
| Show People with Paul Wontorek | 2015 | Self | Self |
| Late Show with David Letterman | 2015 | Self | Self - Guest |
| Listen Up Philip - Behind the Scenes Short | 2015 | Self | Self |
| People Magazine Awards | 2014 | Self | Self |
| Project Runway | 2014 | Self | Self - Guest Judge |
| The Daily Show | 2014 | Self | Self - Guest |
| The Late Late Show with Craig Ferguson | 2013–2014 | Self | Self - Guest |
| E! News | 2014 | Self | Self |
| The 2014 Film Independent Spirit Awards | 2014 | Self | Self - Presenter |
| 20th Annual Screen Actors Guild Awards | 2014 | Self | Self - Nominee |
| 2014 Golden Globe Arrivals Special | 2014 | Self | Self (uncredited) |
| 71st Golden Globe Awards | 2014 | Self | Self - Winner |
| Project Runway All Stars | 2013 | Self | Self - Guest Judge |
| The 65th Primetime Emmy Awards | 2013 | Self | Self - Nominee |
| From the Bottom of the Lake | 2013 | Self | Self |
| The 37th Annual Women in Film Crystal & Lucy Awards TV Special | 2013 | Self | Self - Recipient |
| The Hollywood Reporter Emmy Roundtable | 2013 | Self | Self |
| Late Night with Jimmy Fallon | 2009–2013 | Self | Self - Guest |
| Chelsea Lately | 2013 | Self | Self - Guest |
| Emmys Red Carpet Live | 2012 | Self | Self |
| America in Primetime | 2011 | Self | Self |
| The 63rd Primetime Emmy Awards | 2011 | Self | Self - Nominee |
| 17th Annual Screen Actors Guild Awards | 2011 | Self | Self - Nominee |
| The 68th Annual Golden Globe Awards | 2011 | Self | Self - Nominee |
| The 62nd Primetime Emmy Awards | 2010 | Self | Self - Nominee |
| The Tonight Show with Jay Leno | 2010 | Self | Self - Guest |
| The Bonnie Hunt Show | 2009–2010 | Self | Self - Guest |
| The 67th Annual Golden Globe Awards | 2010 | Self | Self - Audience Member |
| The 61st Primetime Emmy Awards | 2009 | Self | Self - Nominee |
| 2009 Creative Arts Emmy Awards TV Special | 2009 | Self | Self |
| Saturday Night Live | 2009 | Self | Self (uncredited) |
| The 60th Primetime Emmy Awards | 2008 | Self | Self (uncredited) |
| Advertising the American Dream | 2008 | Self | Peggy Olson |
| Establishing Mad Men | 2008 | Self | Self |
| The Best of 'Mad Men' TV Movie | 2008 | Self | Self |
| The 12th Satellite Awards TV Special | 2007 | Self | Self - Winner |
| The Making of 'Mad Men' | 2007 | Self | Self |
| The Independent Spirit Awards Nomination Show | 2004 | Self | Self |
| The 2004 IFP/West Independent Spirit Awards | 2004 | Self | Self - Nominee |
| Christmas in Rockefeller Center | 2003 | Self | Self |
| Hollywood Squares | 2000–2001 | Self | Self - Panelist |
| Circus of the Stars Gives Kids the World | 1993 | Self | Self |
| Entertainment Tonight | 2015–2022 | Archive Footage | Self (archive footage) |
| Hormigueddon | 2020 | Archive Footage | Elisabeth Moss (archive footage) |
| The Last Blockbuster | 2020 | Archive Footage | Self (archive footage, uncredited) |
| The Kelly Clarkson Show | 2020 | Archive Footage | Self (archive footage) |
| Il était une fois... | 2020 | Archive Footage | Self (archive footage, uncredited) |
| Film Önü / Arkasi | 2019 | Archive Footage | Self (archive footage) |
| Celebrity Page | 2018–2019 | Archive Footage | Self (archive footage) |
| Hoy nos toca | 2018 | Archive Footage | Self - The Handmaid's Tale (archive footage) |
| Democracy Now! | 2016 | Archive Footage | Lucy Scott (archive footage) |