| Surface | 2022–2025 | Actress | Sophie |
| Lift | 2024 | Actress | Abby |
| Loki | 2021–2023 | Actress | Judge Renslayer |
| The Girl Before | 2021 | Actress | Jane |
| Summerland | 2020 | Actress | Vera |
| Misbehaviour | 2020 | Actress | Jennifer Hosten - Miss Grenada |
| Come Away | 2020 | Actress | Alice Darling |
| The Morning Show | 2019 | Actress | Hannah Shoenfeld |
| The Dark Crystal: Age of Resistance | 2019 | Actress | Seladon (voice) |
| Motherless Brooklyn | 2019 | Actress | Laura Rose |
| Easy | 2016–2019 | Actress | Sophie |
| Farming | 2018 | Actress | Ms. Dapo |
| Fabled TV Series | 2018 | Actress | Dee |
| Fast Color | 2018 | Actress | Ruth |
| A Wrinkle in Time | 2018 | Actress | Mrs. Murry |
| Irreplaceable You | 2018 | Actress | Abbie |
| The Cloverfield Paradox | 2018 | Actress | Hamilton |
| Beauty and the Beast | 2017 | Actress | Plumette |
| Miss Sloane | 2016 | Actress | Esme Manucharian |
| Black Mirror | 2016 | Actress | Kelly Booth |
| After the Storm | 2016 | Actress | Mother |
| Free State of Jones | 2016 | Actress | Rachel |
| The Whole Truth | 2016 | Actress | Janelle |
| Concussion | 2015 | Actress | Prema Mutiso |
| Jupiter Ascending | 2015 | Actress | Famulus |
| 9 Kisses | 2014 | Actress | Bride |
| Beyond the Lights | 2014 | Actress | Noni |
| Belle | 2013 | Actress | Dido Elizabeth Belle |
| Odd Thomas | 2013 | Actress | Viola Peabody |
| Touch | 2012 | Actress | Clea Hopkins |
| Undercovers | 2010–2012 | Actress | Samantha Bloom |
| Larry Crowne | 2011 | Actress | Talia |
| Capture Anthologies: Love, Lust and Tragedy | 2010 | Actress | Erica (segment "All My Dreams On VHS") |
| Act of God | 2009 | Actress | Rose |
| All My Dreams on VHS | 2009 | Actress | Erica |
| Lost in Austen | 2008 | Actress | Pirhana (as Gugu Mbatha Raw) |
| Bonekickers | 2008 | Actress | Viv Davis |
| Fallout | 2008 | Actress | Shanice Roberts |
| Trial & Retribution | 2008 | Actress | Jenny Miller (as Gugu Mbatha Raw) |
| Doctor Who | 2007 | Actress | Tish Jones |
| Marple | 2007 | Actress | Tina Argyle (as Gugu Mbatha Raw) |
| Closure | 2007 | Actress | Young PA |
| Dead Clever: The Life and Crimes of Julie Bottomley | 2007 | Actress | Jessica |
| Bad Girls | 2006 | Actress | Fidelity Saunders |
| Born Equal | 2006 | Actress | Girl at King's Cross Station (uncredited) |
| MI-5 | 2006 | Actress | Jenny |
| Viva Blackpool | 2006 | Actress | Pretty Young Woman |
| Vital Signs | 2006 | Actress | Eve |
| Walk Away and I Stumble | 2005 | Actress | Nurse |
| Legless | 2005 | Actress | Beth |
| Holby City | 2005 | Actress | Colette Hill |
| Surface | 2025 | Producer | executive producer |
| A Private War | 2018 | Thanks | special thanks from the director |
| The Gift | 2015 | Thanks | special thanks |
| Summerland | 2020 | Soundtrack | performer: "Where's That Rainbow" |
| Nostalgia Critic | 2018 | Soundtrack | performer: "The Mob Song" |
| Beauty and the Beast | 2017 | Soundtrack | performer: "Be Our Guest", "Days In The Sun", "Something There", "The Mob Song" |
| Beyond the Lights | 2014 | Soundtrack | performer: "Masterpiece", "C'mon Boy", "Private Property", "Blackbird" |
| Live with Kelly and Mark | 2022–2025 | Self | Self |
| Sherri | 2025 | Self | Self |
| Entertainment Tonight | 2014–2025 | Self | Self |
| The Graham Norton Show | 2021–2025 | Self | Self - Guest |
| Today | 2010–2024 | Self | Self - Guest |
| Burning Questions | 2024 | Self | Self |
| Marvel Studios: Assembled | 2021–2023 | Self | Self - Ravonna Renslayer |
| Tudum: A Netflix Global Fan Event | 2023 | Self | Self |
| In Creative Company | 2023 | Self | Self |
| 2023 EE BAFTA Film Awards | 2023 | Self | Self |
| Symone | 2022 | Self | Self |
| Good Morning America | 2019–2022 | Self | Self - Guest |
| Paltrocast with Darren Paltrowitz | 2022 | Self | Self |
| Hollywood First Look | 2022 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2020–2022 | Self | Self - Guest |
| The Talk | 2022 | Self | Self - Guest |
| The Daily Show | 2022 | Self | Self - Guest |
| Made in Hollywood | 2011–2021 | Self | Self |
| Pop Culture Weekly with Kyle Mcmahon TV Series | 2021 | Self | Self |
| Access Hollywood | 2016–2021 | Self | Self |
| Jimmy Kimmel Live! | 2014–2021 | Self | Self - Guest |
| EE British Academy Film Awards | 2021 | Self | Self - Presenter |
| Films of Hope | 2020 | Self | Self |
| Good Morning Britain | 2020 | Self | Self - Guest |
| Sunday AM | 2020 | Self | Self |
| The One Show | 2019 | Self | Self - Guest |
| Late Night with Seth Meyers | 2019 | Self | Self - Guest |
| Rachael Ray | 2016–2019 | Self | Self - Guest |
| WGN Morning News | 2017–2019 | Self | Self |
| The Late Late Show with James Corden | 2019 | Self | Self - Guest |
| Film at Lincoln Center TV Series | 2019 | Self | Self |
| CTV News at 11:30 Toronto | 2019 | Self | Self |
| Entertainers with Byron Allen | 2019 | Self | Self |
| Shepard Team: The Cast of 'The Cloverfield Paradox' Video | 2019 | Self | Self |
| Things Are Not As They Appear: The Making of 'The Cloverfield Paradox' Video | 2019 | Self | Self |
| A Journey Through Time | 2018 | Self | Self |
| The EE British Academy Film Awards | 2018 | Self | Self |
| The 69th Primetime Emmy Awards | 2017 | Self | Self |
| 6th NAFCA Annual Show TV Special | 2017 | Self | Self - Nominee |
| The British Academy Britannia Awards | 2016 | Self | Self - Presenter |
| Harry | 2016 | Self | Self - Guest |
| August 28th | 2016 | Self | Self |
| Film '72 | 2016 | Self | Self - Interviewee |
| The 47th NAACP Image Awards | 2016 | Self | Self - presenter |
| The EE British Academy Film Awards | 2015 | Self | Self - Nominee & Presenter |
| The 46th Annual NAACP Image Awards | 2015 | Self | Self - Presenter |
| Variety Studio: Actors on Actors | 2014 | Self | Self |
| Hollywood Sessions | 2014 | Self | Self |
| 24th Annual Gotham Independent Film Awards | 2014 | Self | Self - Presenter |
| Tavis Smiley | 2014 | Self | Self - Guest |
| The Wendy Williams Show | 2014 | Self | Self - Guest |
| Just Seen It | 2014 | Self | Self |
| Last Call with Carson Daly | 2014 | Self | Self - Guest |
| BAFTA Britannia Awards Special 2014 | 2014 | Self | Self - Presenter |
| Belle: The History Behind the Painting Video | 2014 | Self | Self |
| Belle: The Story Video | 2014 | Self | Self |
| BET Awards 2014 | 2014 | Self | Self |
| The Arsenio Hall Show | 2014 | Self | Self - Guest |
| 16th Annual Prism Awards | 2012 | Self | Self |
| 42nd NAACP Image Awards | 2011 | Self | Self |
| The 62nd Primetime Emmy Awards | 2010 | Self | Self - Presenter |
| Doctor Who Confidential | 2007 | Self | Self |
| Totally Doctor Who | 2007 | Self | Self |
| Entertainment Tonight | 2019–2025 | Archive Footage | Self (archive footage) |
| Showrunners: The Art of Running a TV Show | 2014 | Archive Footage | Self - Undercovers, Actress (archive footage) |
| Doctor Who Greatest Moments | 2009 | Archive Footage | Tish Jones (archive footage) |