| The 4:30 Movie | 2024 | Actress | Sister Sarah Wallace |
| Moonburn | 2024 | Actress | Katie |
| (Un)Likeminded: A Sci-Fi Audio Anthology | 2024 | Actress | Calmer II |
| Masters of the Universe: Revolution | 2024 | Actress | Queen Amela (voice) |
| Clerks III | 2022 | Actress | Milly |
| Killroy Was Here | 2022 | Actress | Wendy |
| Student Body | 2022 | Actress | Nadia Parker |
| Swiss and Lali Hijack Hollywood TV Series | 2021 | Actress | Maxine Mayberry |
| Cruel Summer | 2021 | Actress | Mallory Higgins |
| Jelly Short | 2021 | Actress | Lola |
| Nineteen on Fire | 2021 | Actress | Beth |
| Jay and Silent Bob Reboot | 2019 | Actress | Milly |
| Madness in the Method | 2019 | Actress | Harley |
| Once Upon a Time... in Hollywood | 2019 | Actress | 'Froggie' |
| The Real King Lear Short | 2018 | Actress | |
| Hollyweed | 2018 | Actress | |
| All Night | 2018 | Actress | Goth Girl |
| All These Small Moments | 2018 | Actress | Lindsay |
| Supergirl | 2017 | Actress | Izzy Williams |
| Other Fish Short | 2016 | Actress | Sandy (voice) |
| Holidays | 2016 | Actress | Holly (segment: "Halloween") |
| Yoga Hosers | 2016 | Actress | Colleen McKenzie |
| Tusk | 2014 | Actress | Girl Clerk #1 |
| Clerks II | 2006 | Actress | Kid in Window |
| Jersey Girl | 2004 | Actress | Tracy Colelli (uncredited) |
| Jay and Silent Bob Strike Back | 2001 | Actress | Baby Silent Bob |
| Clerks III | 2022 | Thanks | the director would like to thank: For being my favorite actress and my favorite human. (as Harley) |
| Yoga Hosers | 2016 | Thanks | the director would like to thank |
| Rodney Redbottom Short | 2015 | Thanks | special thanks: for the love (as Harley-Quinn) |
| Jay and Silent Bob Get Irish: The Swearing O' the Green | 2013 | Thanks | special thanks |
| Jay and Silent Bob Get Old: Tea Bagging in the UK | 2012 | Thanks | special thanks |
| An Evening with Kevin Smith 2: Evening Harder | 2006 | Thanks | special thanks (as Harley Smith) |
| Clerks II | 2006 | Thanks | the director would like to thank: For being the spring in Dad's step. (as Harley) |
| Jay and Silent Bob Strike Back | 2001 | Thanks | the director would like to thank: for her never-ending fascination with poo-poo (as Harley) |
| Dogma | 1999 | Thanks | the director would like to thank: for giving me the opportunity to raise my own little Catholic (as Harley Quinn) |
| Jay and Silent Bob Reboot | 2019 | Soundtrack | writer: "I Saw a Ghost", "I'll Go When It's My Time" |
| Yoga Hosers | 2016 | Soundtrack | performer: "I'm The Man #1" , "Babe" , "O' Canada" |
| Mercy for Animals 25th Anniversary Gala: Red Carpet Short | 2024 | Self | Self |
| The Boulet Brothers' Dragula | 2023 | Self | Self - Guest Judge |
| Mercy for Animals Gala: Red Carpet Short | 2022 | Self | Self |
| Mercy for Animals Hope Gala: Virtual Red Carpet Short | 2021 | Self | Self |
| Awards Radar TV Series | 2021 | Self | Self |
| In Creative Company | 2021 | Self | Self |
| Clerk | 2021 | Self | Self |
| This is Temporary Podcast Series | 2020 | Self | Self - Guest |
| Day by Day | 2020 | Self | Liza |
| Magnum Dopus: The Making of Jay and Silent Bob Reboot | 2020 | Self | Self |
| Halloween Wars | 2019 | Self | Self - Guest Judge |
| 31 Nights of Halloween Fan Fest | 2019 | Self | Self |
| Good Morning America | 2019 | Self | Self - Guest |
| GMA3: What You Need to Know | 2019 | Self | Self |
| Beings: Harley Quinn Smith Short | 2019 | Self | Self |
| Mercy for Animals 20th Anniversary Gala: Red Carpet Short | 2019 | Self | Self |
| Mercy for Animals: 20th Anniversary Gala | 2019 | Self | Self - Presenter |
| Compassionate Living: Kevin Smith and Harley Quinn Smith Short | 2019 | Self | Self |
| Last Call with Carson Daly | 2019 | Self | Self |
| Collider Live | 2019 | Self | Self |
| The Power of Sanctuary Video | 2018 | Self | Self |
| Changing the Game Video | 2018 | Self | Self - Actor |
| DC Daily | 2018 | Self | Self |
| Hidden Heroes Gala: Red Carpet Short | 2018 | Self | Self |
| Frazer Brown in conversation with... Kevin Smith Podcast Series | 2018 | Self | Self |
| Entertainment Tonight | 2018 | Self | Self |
| Circle V Music Festival: Red Carpet Short | 2017 | Self | Self |
| Hidden Heroes Gala: Red Carpet Short | 2017 | Self | Self |
| National Endowment for the Arts: United States of Arts | 2016 | Self | Self |
| Rogue One: A Star Wars Story - World Premiere | 2016 | Self | Self (uncredited) |
| Comic Book Men | 2014–2016 | Self | Self |
| Hollywood Today Live | 2016 | Self | Self |
| Access Daily | 2016 | Self | Self |
| IMDb at San Diego Comic-Con | 2016 | Self | Self |
| Spoilers with Kevin Smith | 2012 | Self | Self (uncredited) |
| Kevin Smith: Sold Out - A Threevening with Kevin Smith | 2008 | Self | Self |
| An Evening with Kevin Smith 2: Evening Harder | 2006 | Self | Self (uncredited) |
| Oh, What a Lovely Tea Party | 2004 | Self | Self (as Harley) |
| The Power of Sanctuary Video | 2020 | Archive Footage | Self (archive footage) |