| Big Sky | 2021–2023 | Actress | Tonya Walsh |
| The Dinner Party Short | 2022 | Actress | Sage |
| I'm on Fire | 2022 | Actress | Gina |
| The Virgin of Highland Park | 2022 | Actress | Ms. Chapman |
| Triage TV Movie | 2020 | Actress | Dr. Eva Jeffers |
| Elena of Avalor | 2019–2020 | Actress | Rebeca (voice) |
| Beef House | 2020 | Actress | Megan |
| The Neighbor in the Window | 2020 | Actress | Karen Morgan |
| Adventure Force 5 | 2019 | Actress | Mia |
| Mob Town | 2019 | Actress | Josephine Barbara |
| Magnum P.I. | 2018 | Actress | Toni |
| Rob Riggle's Ski Master Academy | 2018 | Actress | Jamie-Lynn Sigler |
| Signed, Sealed, Delivered: The Road Less Traveled | 2018 | Actress | Rachel |
| Gangster Land | 2017 | Actress | Lulu Rolfe |
| Justice | 2017 | Actress | Melissa |
| Mommy, I Didn't Do It | 2017 | Actress | Vera Dutton |
| The Snowy Day | 2016 | Actress | Layla's Mom (voice) |
| Loserville | 2016 | Actress | Coach Aileen Russo |
| Baby Daddy | 2016 | Actress | Sarah Gilcrest |
| CSI: Cyber | 2016 | Actress | Sasha Boyd |
| The Christmas Note | 2015 | Actress | Gretchen |
| Broken Tail Light | 2014 | Actress | Mother |
| Dads | 2014 | Actress | Elsa |
| Anatomy of the Tide | 2013 | Actress | Gina Harper |
| Guys with Kids | 2012–2013 | Actress | Emily |
| Divorce Invitation | 2012 | Actress | Dylan |
| I Do | 2012 | Actress | Ali Federman |
| Jewtopia | 2012 | Actress | Hannah Daniels |
| Last Man Standing | 2012 | Actress | Gabriella |
| Criminal Behavior | 2011 | Actress | Brooke Kross |
| Drop Dead Diva | 2011 | Actress | Tina Howard |
| The Matthew Morrison Story | 2011 | Actress | |
| Son of Morning | 2011 | Actress | Jamie Johnson |
| Trophy Wife | 2010 | Actress | Christina |
| Backwash | 2010 | Actress | Prudence |
| Catblock (The Ultimate Co%kblock) | 2010 | Actress | |
| Beneath the Dark | 2010 | Actress | Adrienne |
| Ugly Betty | 2009 | Actress | Natalie |
| Entourage | 2008–2009 | Actress | Jamie-Lynn Sigler |
| The Real Housewives of New Jersey with Jamie-Lynn Sigler | 2009 | Actress | |
| The Lonely Island: Jizz in My Pants | 2008 | Actress | Cashier |
| Saturday Night Live | 2008 | Actress | Checkout Girl (uncredited) |
| How I Met Your Mother | 2008 | Actress | Jillian |
| The Gathering | 2007 | Actress | Maggy Rule |
| New York City Serenade | 2007 | Actress | Lynn |
| The Sopranos | 1999–2007 | Actress | Meadow Soprano |
| Higglytown Heroes | 2005–2007 | Actress | Ms. Fern |
| Dark Ride | 2006 | Actress | Cathy |
| Blinders | 2006 | Actress | Alexa (as Jamie-Lynn DiScala) |
| Homie Spumoni | 2006 | Actress | Alli Butterman |
| Lovewrecked | 2005 | Actress | Alexis Manetti (as Jamie-Lynn DiScala) |
| Will & Grace | 2004 | Actress | Ro (as Jamie-Lynn DiScala) |
| Extreme Dating | 2004 | Actress | Amy Baker |
| Call Me: The Rise and Fall of Heidi Fleiss | 2004 | Actress | Heidi Fleiss (as Jamie-Lynn DiScala) |
| Death of a Dynasty | 2003 | Actress | Sexy Woman #3 |
| Mariah Carey: Through the Rain | 2002 | Actress | Carey's Mother |
| Campfire Stories | 2001 | Actress | Natalie |
| Jamie Lynn-Sigler: Cry Baby Music Video | 2001 | Actress | Jamie-Lynn Sigler |
| A Brooklyn State of Mind | 1998 | Actress | Young Angie |
| MeSsy with Christina Applegate & Jamie-Lynn Sigler Podcast Series | 2024 | Producer | executive producer |
| I'm on Fire | 2022 | Producer | executive producer |
| The Sopranos | 1999–2001 | Soundtrack | performer: "Breathless" |
| Conan O'Brien Needs a Friend | 2025 | Self | Self |
| The $100,000 Pyramid | 2019–2025 | Self | Self - Celebrity Contestant |
| What's Your Limp? | 2025 | Self | Self - Guest |
| Today | 2001–2024 | Self | Self - Guest |
| The Kelly Clarkson Show | 2024 | Self | Self - Guest |
| That One Audition Podcast Series | 2024 | Self | Self |
| The Talk | 2013–2024 | Self | Self - Guest Co-Host |
| Good Morning America | 2000–2024 | Self | Self - Guest |
| GMA3: What You Need to Know | 2024 | Self | Self |
| CNN New Year's Eve Live with Anderson Cooper & Andy Cohen | 2023 | Self | Self |
| 69 Minutes with Tom Segura | 2023 | Self | Self |
| Inside of You with Michael Rosenbaum | 2018–2023 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2012–2023 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2022 | Self | Self - Guest |
| Live with Kelly and Mark | 2002–2022 | Self | Self |
| The Real Housewives of Orange County | 2021 | Self | Self |
| I Have A Podcast | 2021 | Self | Self |
| Talking Sopranos | 2020–2021 | Self | Self |
| 25 Words or Less | 2019–2021 | Self | Self - Contestant |
| Navigating the New Normal: Parents Edition TV Special | 2020 | Self | Self |
| Entertainment Tonight | 2007–2020 | Self | Self - Guest Co-Host |
| Access Hollywood | 2016–2020 | Self | Self |
| Home & Family | 2020 | Self | Self |
| 2019 MTV Video Music Awards | 2019 | Self | Self - Presenter |
| Where My Moms At? | 2019 | Self | Self |
| Katie's Crib Podcast Series | 2019 | Self | Self - Guest |
| Celebrity Page | 2017–2019 | Self | Self |
| At This Hour with Kate Bolduan | 2018 | Self | Self |
| Epic Fail Podcast Series | 2017 | Self | Self - Guest (voice) |
| Unsend | 2017 | Self | Self |
| Hollywood Medium | 2017 | Self | Self |
| Harry | 2016 | Self | Self |
| Oprah: Where Are They Now? | 2016 | Self | Self |
| Access Daily | 2015–2016 | Self | Self |
| The Doctors | 2016 | Self | Self |
| The Dr. Oz Show | 2016 | Self | Self |
| Long Island Medium | 2016 | Self | Self |
| The Real Girl's Kitchen | 2015 | Self | Self |
| Celebrity Name Game | 2014–2015 | Self | Self - Celebrity Player |
| James Gandolfini: Tribute to a Friend | 2013 | Self | Self |
| Hollywood Game Night | 2013 | Self | Self - Panelist |
| RuPaul's Drag Race | 2013 | Self | Self - Guest Judge |
| Through the Mind's Eye of Colleen Atwood | 2013 | Self | Self |
| The Wendy Williams Show | 2010–2012 | Self | Self - Guest |
| Late Night with Jimmy Fallon | 2009–2012 | Self | Self - Guest |
| Big Morning Buzz Live | 2012 | Self | Self - Guest |
| On the List with Brett Gursky Podcast Series | 2012 | Self | Self |
| Asia Uncut with Jon Niermann TV Series | 2010 | Self | Self |
| The 2009 Primetime Creative Arts Emmy Awards | 2009 | Self | Self |
| 2009 Alma Awards TV Special | 2009 | Self | Self |
| 2009 MTV Video Music Awards | 2009 | Self | Self - Presenter |
| Jimmy Kimmel Live! | 2004–2009 | Self | Self - Guest |
| Up Close with Carrie Keagan | 2009 | Self | Self |
| In the Shadow of the Acropolis Short | 2008 | Self | (voice) |
| American Idol | 2008 | Self | Self - Audience |
| The Sopranos: A Sitdown | 2007 | Self | Self |
| Rachael Ray | 2007 | Self | Self - Guest |
| The View | 2000–2007 | Self | Self - Co-Host |
| 13th Annual Screen Actors Guild Awards | 2007 | Self | Self - Nominee |
| Battling Eating Disorders Video | 2006 | Self | Self |
| 20/20 | 2006 | Self | Self (as Jamie-Lynn Siegler) |
| The 60th Annual Tony Awards | 2006 | Self | Self - Presenter |
| In the Cutz | 2006 | Self | Self (as Jamie-Lynn DiScala) |
| Late Night with Conan O'Brien | 2002–2006 | Self | Self - Guest |
| Your Total Health | 2006 | Self | Self |
| Celebrity Weddings: In Style | 2006 | Self | Self (as Jamie-Lynn DiScala) |
| Showbiz Tonight | 2005 | Self | Self (as Jamie-Lynn DiScala) |
| Paula Zahn Now | 2005 | Self | Self - Guest (as Jamie-Lynn DiScala) |
| Kathy Griffin: My Life on the D-List | 2005 | Self | Self - Guest (as Jamie-Lynn DiScala) |
| Punk'd | 2005 | Self | Self (as Jamie-Lynn DiScala) |
| Newlyweds: Nick & Jessica | 2005 | Self | Self (as Jamie-Lynn DiScala) |
| 11th Annual Screen Actors Guild Awards | 2005 | Self | Self - Nominee |
| I Love the '90s: Part Deux | 2005 | Self | Self (as Jamie-Lynn DiScala) |
| Celebrity Blackjack | 2004 | Self | Self (as Jamie-Lynn DiScala) |
| Fashion Rocks | 2004 | Self | Self |
| Late Show with David Letterman | 2003–2004 | Self | Self - Guest |
| On-Air with Ryan Seacrest | 2004 | Self | Self - Guest (as Jamie-Lynn DiScala) |
| The Ellen DeGeneres Show | 2004 | Self | Self - Guest (as Jamie-Lynn DiScala) |
| MTV Fake ID Club TV Series | 2004 | Self | Self - Host |
| The Sharon Osbourne Show | 2003 | Self | Self - Guest (as Jamie-Lynn DiScala) |
| 9th Annual Screen Actors Guild Awards | 2003 | Self | Self - Nominee |
| The 45th Annual Grammy Awards | 2003 | Self | Self - Presenter (as Jamie-Lynn DiScala) |
| The Caroline Rhea Show | 2002 | Self | Self - Guest |
| Macy's Thanksgiving Day Parade | 2002 | Self | Self |
| Last Call with Carson Daly | 2002 | Self | Self - Guest |
| CBS Mornings | 2002 | Self | Self - Guest |
| Face to Face with Connie Chung TV Series | 2002 | Self | Self - Guest |
| 2002 ALMA Awards | 2002 | Self | Self |
| 8th Annual Screen Actors Guild Awards | 2002 | Self | Self - Nominee |
| Broadway's Best | 2002 | Self | Self (as Jamie-Lynn DiScala) |
| Wright Here, Wright Now TV Movie | 2002 | Self | Self |
| Top Ten | 2001 | Self | Self |
| The Big Breakfast | 2001 | Self | Self - Guest |
| Total Request Live | 2001 | Self | Self |
| Pop TV TV Series | 2001–2003 | Self | Self (2002) |
| The Tonight Show with Jay Leno | 2001 | Self | Self - Guest |
| Politically Incorrect | 2001 | Self | Self |
| The Rosie O'Donnell Show | 2001 | Self | Self - Guest |
| The Oprah Winfrey Show | 2000 | Self | Self - Guest |
| The 57th Annual Golden Globe Awards | 2000 | Self | Self - Audience Member |
| The 51st Annual Primetime Emmy Awards | 1999 | Self | Self |
| Intimate Portrait | 1990–2005 | Self | Self |
| Wise Guy: David Chase and the Sopranos | 2024 | Archive Footage | Self (archive footage) |
| Inside Edition | 2024 | Archive Footage | Self (archive footage) |
| Entertainment Tonight | 2017–2024 | Archive Footage | Self (archive footage) |
| Redbar | 2023 | Archive Footage | Self (archive footage) |
| Celebrity Page | 2017–2019 | Archive Footage | Self (archive footage) |
| Extra | 2016–2019 | Archive Footage | Self (archive footage) |
| RuPaul's Drag Race | 2013 | Archive Footage | Self - Guest Judge (archive footage) |
| The Real Sopranos | 2006 | Archive Footage | Meadow Soprano (archive footage) |
| City of Men | 2005 | Archive Footage | Self (archive footage, uncredited) |