| Hurry Up Tomorrow | 2025 | Actress | Anima |
| The Weeknd: Drive | 2025 | Actress | |
| Death of a Unicorn | 2025 | Actress | Ridley |
| Beetlejuice Beetlejuice | 2024 | Actress | Astrid Deetz |
| Sabrina Carpenter: Taste | 2024 | Actress | Girlfriend |
| Winter Spring Summer or Fall | 2024 | Actress | Remi |
| Doritos: Dinamita | 2024 | Actress | Jenna |
| Miller's Girl | 2024 | Actress | Cairo Sweet |
| Finestkind | 2023 | Actress | Mabel |
| Scream VI | 2023 | Actress | Tara Carpenter |
| Wednesday | 2022 | Actress | Wednesday Addams |
| Jurassic World Camp Cretaceous | 2020–2022 | Actress | Brooklynn (voice) |
| Big City Greens | 2019–2022 | Actress | Gabriella Espinosa (voice) |
| American Carnage | 2022 | Actress | Camila |
| X | 2022 | Actress | Lorraine |
| Studio 666 | 2022 | Actress | Skye Willow |
| Scream | 2022 | Actress | Tara Carpenter |
| The Fallout | 2021 | Actress | Vada Cavell |
| Yes Day | 2021 | Actress | Katie Torres |
| The Babysitter: Killer Queen | 2020 | Actress | Phoebe |
| Elena of Avalor | 2016–2020 | Actress | Princess Isabel |
| Home Movie: The Princess Bride | 2020 | Actress | Princess Buttercup |
| You | 2019 | Actress | Ellie Alves |
| Elena of Avalor: Discovering the Magic Within | 2019 | Actress | Princess Isabel (voice) |
| Wyrm | 2019 | Actress | Suzie |
| Jane the Virgin | 2014–2019 | Actress | Young Jane |
| Girl Code | 2019 | Actress | Olivia |
| Man of the House | 2018 | Actress | Elena |
| Saving Flora | 2018 | Actress | Dawn |
| Disney Channel Stars: Legendary | 2018 | Actress | Jenna Ortega |
| Stuck in the Middle | 2016–2018 | Actress | Harley Diaz |
| Bizaardvark | 2018 | Actress | Izzy |
| Elena of Avalor: Adventures in Vallestrella | 2017 | Actress | Princess Isabel (voice) |
| Jacob Sartorius: Chapstick | 2017 | Actress | Jenna Ortega |
| After Words | 2015 | Actress | Anna |
| The Massively Mixed-Up Middle School Mystery | 2015 | Actress | Elena Mendoza |
| Richie Rich | 2015 | Actress | Darcy |
| Know It All Nina | 2014–2015 | Actress | Nina |
| The Cookie Mobster | 2014 | Actress | Nita |
| Over the Garden Wall | 2014 | Actress | Additional Voices (voice) |
| Young Love | 2014 | Actress | Girl |
| OMG! | 2014 | Actress | Princess Sleigha |
| AwesomenessTV | 2014 | Actress | Lily |
| Rake | 2014 | Actress | Zoe Leon |
| The Little Rascals Save the Day | 2014 | Actress | Mary Ann |
| Colgate Kids Presents: No More Nasties with Jenna Ortega | 2013 | Actress | Jenna Ortega |
| Deadtime Stories | 2013 | Actress | Little Girl |
| Insidious: Chapter 2 | 2013 | Actress | Annie |
| Days of Our Lives | 2013 | Actress | Hayley |
| Iron Man 3 | 2013 | Actress | Vice President's Daughter |
| CSI: NY | 2012 | Actress | Aimee Moore |
| Rob | 2012 | Actress | Girl |
| Hurry Up Tomorrow | 2025 | Producer | executive producer |
| Death of a Unicorn | 2025 | Producer | executive producer |
| MaXXXine | 2024 | Thanks | the producers wish to thank |
| Pearl | 2022 | Thanks | the producers wish to thank |
| 2022 MTV Movie & TV Awards | 2022 | Thanks | thanks |
| Saturday Night Live | 2023 | Soundtrack | performer: "Road Trip" |
| Wednesday | 2022 | Soundtrack | performer: "Four Seasons: Winter: I. Allegro Non Molto" (uncredited) |
| The Fallout | 2021 | Soundtrack | performer: "Conversations" |
| Yes Day | 2021 | Soundtrack | performer: "Baby I Need Your Loving" |
| Elena of Avalor | 2016–2017 | Soundtrack | performer: "Grown Up Enough" |
| Entertainment Tonight | 2020–2025 | Self | Self |
| The Late Show with Stephen Colbert | 2025 | Self | Self - Guest |
| FilmUpdates TV Series | 2025 | Self | Self |
| The 31st Annual Screen Actors Guild Awards | 2025 | Self | Self - Scream Queens Segment |
| SNL50: The Anniversary Special | 2025 | Self | Self - Audience Member |
| SNL50: The Homecoming Concert | 2025 | Self | Self - Audience Member |
| The Juice is Loose: The Making of Beetlejuice Beetlejuice | 2024 | Self | Self |
| My Generation | 2024 | Self | Narrator |
| BuzzFeed UK TV Series | 2024 | Self | Self |
| Harper's Bazaar: YouTube Channel TV Series | 2024 | Self | Self |
| Den of Geek TV Series | 2024 | Self | Self - Guest |
| IMDb Interviews | 2024 | Self | Self - Guest |
| Jornal Nacional | 2024 | Self | Self (uncredited) |
| ABC News Breakfast | 2024 | Self | Self - Guest |
| The Project | 2024 | Self | Self - Guest |
| Access Hollywood | 2022–2024 | Self | Self |
| FRED: The Festival Insider | 2024 | Self | Self |
| Dish Nation | 2021–2024 | Self | Self |
| ELLE: YouTube Channel | 2024 | Self | Self |
| Letterboxd TV Series | 2024 | Self | Self |
| BuzzFeed Celeb | 2024 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2022–2024 | Self | Self - Guest |
| Today | 2022–2024 | Self | Self - Guest |
| Untitled Tim Burton Documentary | 2024 | Self | Self |
| Vanity Fair: YouTube Channel | 2024 | Self | Self |
| The 75th Primetime Emmy Awards | 2024 | Self | Self - Nominee & Presenter |
| Harper's Bazaar UK TV Series | 2023 | Self | Self |
| Dior: YouTube Channel | 2023 | Self | Self |
| Tudum: A Netflix Global Fan Event | 2023 | Self | Self |
| Variety Studio: Actors on Actors | 2023 | Self | Self - Guest |
| 2023 MTV Movie & TV Awards | 2023 | Self | Self |
| Saturday Night Live | 2023 | Self | Self - Host |
| Konbini | 2022–2023 | Self | Self |
| Extra | 2023 | Self | Self |
| eTalk Daily | 2023 | Self | Self |
| Nickelodeon Kids' Choice Awards 2023 | 2023 | Self | Self |
| Hot Ones | 2023 | Self | Self - Guest |
| IMDb Originals | 2023 | Self | Self - Guest |
| The 29th Annual Screen Actors Guild Awards | 2023 | Self | Self - Nominee & Presenter |
| 80th Golden Globe Awards | 2023 | Self | Self - Nominee & Presenter |
| WIRED: Jenna Ortega Answers the Web's Most Searched Questions Video | 2022 | Self | Self - Guest |
| Jimmy Kimmel Live! | 2022 | Self | Self - Guest |
| Tudum: A Netflix Global Fan Event | 2022 | Self | Self |
| Podcrushed | 2022 | Self | Self - Guest |
| 2022 MTV Movie & TV Awards | 2022 | Self | Self - Presenter & Winner |
| Celebrity Page | 2022 | Self | Self |
| The Drew Barrymore Show | 2021–2022 | Self | Self - Guest |
| Good Morning America | 2021 | Self | Self - Guest |
| Tamron Hall | 2021 | Self | Self |
| Just Between Us with sisters Bailee Madison and Kaitlin Vilasuso Podcast Series | 2019 | Self | Self |
| Pixar Pier Disneyland Takeover | 2018 | Self | Self |
| Disney Quizney | 2018 | Self | Self |
| Radio Disney Music Awards | 2018 | Self | Self - Presenter |
| Kiki Mobile | 2017 | Self | Self |
| Be Your Best Snackdown | 2017 | Self | Self |
| Radio Disney Music Awards | 2017 | Self | Self - Hostess |
| Disney Parks Presents: A Descendants Magical Holiday Celebration | 2016 | Self | Self |
| Disney Channel: Jenna Ortega - Hispanic Heritage Video | 2016 | Self | Self |
| 31st Annual Imagen Awards | 2016 | Self | Self |
| Piper's Picks TV | 2016 | Self | Self - Guest |
| American Latino TV | 2016 | Self | Self - Guest |
| Red Carpet Report | 2016 | Self | Self |
| The 24th Annual Movieguide Awards | 2016 | Self | Self |
| IMDb on the Scene | 2015 | Self | Self - Guest |
| E! Live from the Red Carpet | 2012–2013 | Self | Self |
| 420 Awards - 6th Annual Event TV Special | 2025 | Archive Footage | Self - Nominee (archive footage) |
| Entertainment Tonight | 2020–2025 | Archive Footage | Self (archive footage) |
| SNL50: Beyond Saturday Night | 2025 | Archive Footage | Self (archive footage) |
| TLDR Business TV Series | 2024 | Archive Footage | Wednesday Addams (archive footage) |
| ABC News Breakfast | 2024 | Archive Footage | Self - Guest (archive footage, uncredited) |
| Access Hollywood | 2024 | Archive Footage | Self (archive footage) |
| Morgenmagazin | 2024 | Archive Footage | Self (archive footage) |
| The Comments Section | 2023 | Archive Footage | Self (archive footage) |
| Entertainment Tonight Canada | 2023 | Archive Footage | Self (archive footage) |
| FRO Thizzle Reviews | 2023 | Archive Footage | Self (archive footage) |
| Dish Nation | 2023 | Archive Footage | Self (archive footage) |
| Podcrushed | 2023 | Archive Footage | Self - Guest (archive footage) |
| Inside Edition Weekend | 2022 | Archive Footage | Self (archive footage) |
| The Heller Awards | 2022 | Archive Footage | Self (archive footage) |