| Bride Wars | 2015 | Writer | based upon the screenplay by |
| The Confrontation Short | 2014 | Writer | written by |
| Ass Backwards | 2013 | Writer | written by |
| Crying in Public | 2011 | Writer | written by |
| Bride Wars | 2009 | Writer | screenplay |
| Exclusive Dark Knight Deleted Scene | 2008 | Writer | writer |
| Pantsed Short | 2008 | Writer | written by |
| The Very Funny Show | 2007 | Writer | writer |
| UCB Comedy Originals | 2007–2020 | Writer | written by |
| Creature Comforts America | 2007 | Writer | writer |
| Caffeine: A Love Story Short | 2006 | Writer | written by |
| Big Mouth | 2017–2025 | Actress | Devin LeSeven (voice) |
| Big City Greens | 2023–2025 | Actress | Babe (voice) |
| Abbott Elementary | 2023–2025 | Actress | Elizabeth Washington |
| American Dad! | 2011–2025 | Actress | Suze |
| How Did This Get Made? | 2020–2024 | Actress | |
| Based on a True Story | 2023–2024 | Actress | Romy Lipinski |
| Krapopolis | 2024 | Actress | Eurynomos' Wife (voice) |
| The Loud House | 2023 | Actress | Bella 'Big' Bucks (voice) |
| Frasier | 2023 | Actress | June Patrick |
| The Morning Show | 2023 | Actress | Eagle News Anchor |
| Every Part of You | 2023 | Actress | Claire |
| Moon Girl and Devil Dinosaur | 2023 | Actress | Mrs. Muzzler (voice) |
| Scrambled | 2023 | Actress | Monroe (uncredited) |
| Little Demon | 2022 | Actress | Amanda (voice) |
| Everything's Trash | 2022 | Actress | Jax |
| Home Economics | 2022 | Actress | Lauren |
| Grace and Frankie | 2015–2022 | Actress | Brianna Hanson |
| Cheaper by the Dozen | 2022 | Actress | Anne |
| 8-Bit Christmas | 2021 | Actress | Kathy Doyle |
| Star Trek: Lower Decks | 2021 | Actress | Queen Paolana (voice) |
| Nine Perfect Strangers | 2021 | Actress | Erin (voice, uncredited) |
| Black Monday | 2020–2021 | Actress | Corky Harris |
| Yes Day | 2021 | Actress | Aurora Peterson (uncredited) |
| The Goldbergs | 2021 | Actress | Pamela |
| The High Note | 2020 | Actress | Gail |
| Errands TV Series | 2020 | Actress | Cassandra Banks |
| Daddio | 2019 | Actress | Lilly |
| Long Shot | 2019 | Actress | Maggie Millikin |
| I'm Sorry | 2019 | Actress | Jill |
| Splitting Up Together | 2019 | Actress | Tamryn Tomas Vandaloo |
| Fresh Off the Boat | 2019 | Actress | Guru Sheela |
| Little Big Awesome | 2018 | Actress | Sheena (voice) |
| New Girl | 2012–2018 | Actress | Sadie |
| Blockers | 2018 | Actress | Brenda |
| Curb Your Enthusiasm | 2017 | Actress | Bebe |
| The Disaster Artist | 2017 | Actress | Robyn |
| Playing House | 2017 | Actress | Vanessa |
| Bajillion Dollar Propertie$ | 2017 | Actress | Sabra |
| Veep | 2017 | Actress | Helen Wright |
| Threadbare TV Series | 2017 | Actress | Jackie |
| Girlfriend's Day | 2017 | Actress | Karen Lamb |
| Bad Guys | 2016 | Actress | HR Rep (voice) |
| The Amazing Gayl Pile | 2016 | Actress | Mindy Walker-Fantino |
| Another Period | 2016 | Actress | Eleanor Roosevelt |
| Lady Dynamite | 2016 | Actress | Karen Grisham (Real Estate Agent) |
| The Muppets. | 2016 | Actress | Lucy Royce |
| The League | 2014–2015 | Actress | Teacher Pam |
| The Hotwives of Las Vegas | 2015 | Actress | Jandice |
| Bad Night | 2015 | Actress | Mrs. Goldstein |
| Marry Me | 2015 | Actress | Molly |
| Unfinished Business | 2015 | Actress | Susan Trunkman |
| The Birthday Boys | 2014 | Actress | Barbara O'Shaughnessy |
| Burning Love 3: Burning Down the House | 2014 | Actress | |
| BoJack Horseman | 2014 | Actress | Golden Globes Announcer |
| The Confrontation Short | 2014 | Actress | Javert |
| The Greatest Event in Television History | 2014 | Actress | Emily Scott |
| Burning Love | 2012–2013 | Actress | Julie Gristlewhite |
| NTSF:SD:SUV | 2011–2013 | Actress | Piper Ferguson |
| Anchorman 2: The Legend Continues | 2013 | Actress | Chani's Boss |
| Parks and Recreation | 2013 | Actress | Tynnyfer |
| Drunk History | 2013 | Actress | Isabella Stewart Gardner |
| Inside Amy Schumer | 2013 | Actress | Mandy (as June Raphael) |
| Kroll Show | 2013 | Actress | Dina Bludd |
| Ass Backwards | 2013 | Actress | Kate |
| Whitney | 2012–2013 | Actress | Chloe |
| You're Whole | 2012–2014 | Actress | Wife |
| Susan 313 | 2012 | Actress | Jenny |
| Animal Practice | 2012 | Actress | Dr. Jill Leiter |
| Girl Most Likely | 2012 | Actress | Dara |
| Electric City | 2012 | Actress | Eva Jacobs |
| First Dates with Toby Harris | 2011–2012 | Actress | Toby's Date |
| Bachelorette | 2012 | Actress | Cool Stripper |
| Free Agents | 2012 | Actress | Julie |
| Coffee Snobs | 2011 | Actress | Customer |
| Dropout | 2011 | Actress | Dazzler |
| Crying in Public | 2011 | Actress | Gym Crier |
| Happy Endings | 2011 | Actress | Melinda Shershow (as June Raphael) |
| Funny or Die Presents... | 2010–2011 | Actress | Det. Phuk (segment "United States Police Department") |
| Weakness | 2010 | Actress | Elizabeth |
| Going the Distance | 2010 | Actress | Karen |
| Big Lake | 2010 | Actress | Miss Hauser |
| Players | 2010 | Actress | Barb Tolan |
| Wax on, Fuck Off | 2010 | Actress | Ralph's Wife |
| Party Down | 2010 | Actress | Danielle Lugozshe |
| Cried Suicide Video | 2010 | Actress | Jessica |
| Comedy Bang Bang: The Podcast | 2010 | Actress | Cathy McDowell (voice) |
| The Dry Land | 2010 | Actress | Susie |
| Year One | 2009 | Actress | Maya |
| In the Motherhood | 2009 | Actress | Liz |
| Bride Wars | 2009 | Actress | Amanda |
| Exclusive Dark Knight Deleted Scene | 2008 | Actress | Car Insurance Woman |
| Human Giant | 2007–2008 | Actress | Casting Director |
| Forgetting Sarah Marshall | 2008 | Actress | Ann at the Bar (as June Raphael) |
| Pantsed Short | 2008 | Actress | June |
| The Very Funny Show | 2007 | Actress | Various |
| UCB Comedy Originals | 2007–2020 | Actress | |
| Flight of the Conchords | 2007 | Actress | Felicia (as June Raphael) |
| Creature Comforts America | 2007 | Actress | Interviewer (voice) |
| Derek and Simon: The Show | 2007 | Actress | June (as June Raphael) |
| Zodiac | 2007 | Actress | Mrs. Toschi (as June Raphael) |
| Talkshow with Spike Feresten | 2006 | Actress | Various |
| Caffeine: A Love Story Short | 2006 | Actress | June (as June Raphael) |
| The Wedding Weekend | 2006 | Actress | Ted's Tammy (as June Raphael) |
| Ed | 2002 | Actress | Student |
| Origin Story | 2018 | Producer | producer |
| Ass Backwards | 2013 | Producer | executive producer |
| Caffeine: A Love Story Short | 2006 | Producer | producer |
| Origin Story | 2018 | Camera and Electrical Department | additional camera |
| Creature Comforts America | 2007 | Additional Crew | story editor |
| Yes Day | 2021 | Thanks | special thanks |
| In a World... | 2013 | Thanks | thanks |
| Big Mouth | 2019 | Soundtrack | performer: "Disclosure (The Musical)" |
| In the Kitchen with Harry Hamlin | 2025 | Self | Self |
| Hollywood Squares | 2025 | Self | Self - Panelist |
| RuPaul's Drag Race | 2025 | Self | Self - Guest Judge |
| The $100,000 Pyramid | 2025 | Self | Self - Celebrity Contestant |
| The Talk | 2024 | Self | Self |
| The Give Back-ular Spectacular TV Special | 2023 | Self | |
| Celebrity Family Feud | 2017–2023 | Self | Self - Contestant |
| How Did This Get Made? | 2010–2023 | Self | Self - Host |
| Pickled | 2022 | Self | Self |
| Ask Ronna | 2022 | Self | Self |
| Celebrity Wheel of Fortune | 2022 | Self | Self - Celebrity Contestant |
| Jane Fonda & Lily Tomlin: Ladies Night Live | 2022 | Self | Self |
| The Kelly Clarkson Show | 2022 | Self | Self |
| The Late Late Show with James Corden | 2019–2022 | Self | Self |
| In Creative Company | 2022 | Self | Self |
| The Drew Barrymore Show | 2020–2022 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2020–2022 | Self | Self - Guest |
| Today | 2015–2022 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2021–2022 | Self | Self - Guest |
| Tamron Hall | 2022 | Self | Self |
| Made in Hollywood | 2019–2021 | Self | Self |
| Jimmy Kimmel Live! | 2009–2021 | Self | Self - Guest |
| The 2021 Primetime Creative Arts Emmy Awards | 2021 | Self | Self - Presenter |
| Nailed It! | 2021 | Self | Self - Guest Judge |
| Full Frontal with Samantha Bee | 2021 | Self | Self |
| To Tell the Truth | 2021 | Self | Self - Panelist |
| The Deep Dive with Jessica St. Clair and June Diane Raphael Podcast Series | 2021 | Self | Self - Host |
| 25 Words or Less | 2020 | Self | Self |
| Grace and Frankie Live Table Read TV Special | 2020 | Self | Self |
| Late Night with Seth Meyers Podcast | 2020 | Self | Self - Guest |
| Late Night with Seth Meyers | 2020 | Self | Self |
| Good Mythical Morning | 2019 | Self | Self |
| WTF with Marc Maron | 2019 | Self | Self - Guest |
| All's Fair in Love & Politics: Making Longshot Short | 2019 | Self | Self |
| Charlize Theron and June Diane Raphael's Intense Drinking Game Short | 2019 | Self | Self |
| Front Row Flynn | 2018 | Self | Self - Moderator |
| Origin Story | 2018 | Self | Self |
| Last Call with Carson Daly | 2018 | Self | Self |
| Larry King Now | 2018 | Self | Self - Guest |
| The Late Show with Stephen Colbert | 2018 | Self | Self |
| Hollywood Today Live | 2017 | Self | Self |
| Unqualified | 2016 | Self | Self - Guest |
| Baby Talk | 2015 | Self | Self |
| James Bonding Podcast Series | 2014 | Self | Self |
| Best Week Ever | 2013 | Self | Self - Special Guest |
| Bethenny | 2013 | Self | Self |
| The Pete Holmes Show | 2013 | Self | Self - Guest |
| @midnight | 2013 | Self | Self |
| Roast of James Franco: Red Carpet Pre-Show | 2013 | Self | Self |
| Comedy Central Roasts | 2013 | Self | Self - Audience Member (uncredited) |
| The ArScheerio Paul Show | 2013 | Self | Andrew Dice Clay |
| The Matthew Aaron Show Podcast Podcast Series | 2013 | Self | Self - Guest |
| The Fogelnest Files | 2013 | Self | Self - Guest |
| Metacafe Unfiltered TV Series | 2013 | Self | Self |
| The Late Late Show with Craig Ferguson | 2012 | Self | Self - Guest |
| Comic Con 2012 Live | 2012 | Self | Self |
| A Night of 140 Tweets: A Celebrity Tweet-A-Thon for Haiti | 2010 | Self | Self - @MsJuneDiane |
| Death Panel Advisors | 2009 | Self | Self |
| UCB Comedy Originals | 2007–2020 | Self | Self |
| 2020 | 2020 | Archive Footage | Self (archive footage) |