| Harley Quinn | 2019–2025 | Actress | Harley Quinn |
| Based on a True Story | 2023–2024 | Actress | Ava Bartlett |
| (Un)Likeminded: A Sci-Fi Audio Anthology | 2024 | Actress | Jennifer Wright |
| Kite Man: Hell Yeah! | 2024 | Actress | Harley Quinn (voice) |
| Role Play | 2024 | Actress | Emma Brackett |
| Meet Cute | 2022 | Actress | Sheila |
| The Man from Toronto | 2022 | Actress | Anne |
| The Flight Attendant | 2020–2022 | Actress | Cassie Bowden |
| Curb Your Enthusiasm | 2021 | Actress | Heidi |
| Killer Movie: Director's Cut | 2021 | Actress | Blanca Champion |
| Young Sheldon | 2019 | Actress | Pool (voice, uncredited) |
| The Big Bang Theory | 2007–2019 | Actress | Penny Hofstadter |
| Handsome: A Netflix Mystery Movie | 2017 | Actress | Kaley Cuoco |
| Why Him? | 2016 | Actress | Justine (voice) |
| Alvin and the Chipmunks: The Road Chip | 2015 | Actress | Eleanor (voice) |
| Burning Bodhi | 2015 | Actress | Katy |
| The Wedding Ringer | 2015 | Actress | Gretchen Palmer (as Kaley Cuoco-Sweeting) |
| Aloe Blacc: Can You Do This | 2014 | Actress | Gretchen Palmer (as Kaley Cuoco-Sweeting) |
| A Million Ways to Die in the West | 2014 | Actress | Woman in the Store (uncredited) |
| Authors Anonymous | 2014 | Actress | Hannah Rinaldi |
| Toyota RAV4: Baby Translator | 2013 | Actress | Genie |
| Bratz: Go to Paris the Movie | 2013 | Actress | Twievil (voice) |
| Ultimate Gamer: Diablo 3 | 2012 | Actress | |
| Drew Peterson: Untouchable | 2012 | Actress | Stacy Peterson |
| Barenaked Ladies: The Big Bang Theory Theme | 2011 | Actress | Kaley Cuoco |
| The Last Ride | 2011 | Actress | Wanda |
| Hop | 2011 | Actress | Sam O'Hare |
| The Penthouse | 2010 | Actress | Erica |
| Monster Allergy | 2005–2008 | Actress | Elena Potato |
| Killer Movie | 2008 | Actress | Blanca Champion |
| Cougar Club | 2007 | Actress | Amanda |
| Prison Break | 2007 | Actress | Sasha |
| To Be Fat Like Me | 2007 | Actress | Alyson |
| Separated at Worth | 2006 | Actress | Gabby |
| Secrets of a Small Town | 2006 | Actress | Misty Anders |
| Bratz | 2005–2006 | Actress | Kirstee |
| Bratz: Passion 4 Fashion - Diamondz | 2006 | Actress | Kirstee (voice) |
| Bratz: Forever Diamondz | 2006 | Actress | Kirstee (voice) |
| Brandy & Mr. Whiskers | 2004–2006 | Actress | Brandy Harrington (voice) |
| Bratz Passion 4 Fashion DVD Game | 2006 | Actress | Kirstee (voice) |
| Charmed | 2005–2006 | Actress | Billie Jenkins |
| Loonatics Unleashed | 2005–2006 | Actress | Paula Hayes |
| Wasted | 2006 | Actress | Katie |
| Bratz: Genie Magic | 2006 | Actress | Kirstee (voice) |
| Lucky 13 | 2005 | Actress | Sarah Baker |
| Bratz Rock Angelz | 2005 | Actress | Kirstee (voice) |
| Bratz: Rock Angelz | 2005 | Actress | Kirstee (voice) |
| 8 Simple Rules | 2002–2005 | Actress | Bridget Hennessy |
| Complete Savages | 2004 | Actress | Erin |
| Debating Robert Lee | 2004 | Actress | Maralee Rodgers |
| The Hollow | 2004 | Actress | Karen |
| Crimes of Fashion | 2004 | Actress | Brooke |
| 10.5 | 2004 | Actress | Amanda Williams |
| The Help | 2004 | Actress | Carly Michaels |
| The Ellen Show | 2002 | Actress | Vanessa |
| The Nightmare Room | 2002 | Actress | Kristin Ferris |
| First Monday | 2002 | Actress | Alyssa |
| Nathan's Choice | 2001 | Actress | Olivia |
| 7th Heaven | 2001 | Actress | Lynn |
| Ladies Man | 2000–2001 | Actress | Bonnie Stiles |
| Homewood P.I. | 2000 | Actress | Lauren Crane |
| Growing Up Brady | 2000 | Actress | Maureen McCormick |
| Alley Cats Strike | 2000 | Actress | Elisa Bowers |
| Can't Be Heaven | 1999 | Actress | Teresa Powers |
| The Tony Danza Show | 1998 | Actress | Pammie Green |
| Mr. Murder | 1998 | Actress | Charlotte Stillwater |
| Toothless | 1997 | Actress | Lori |
| Picture Perfect | 1997 | Actress | Little Girl |
| Ellen | 1996 | Actress | Little Ellen |
| Virtuosity | 1995 | Actress | Karin Carter |
| My So-Called Life | 1994 | Actress | Young Angela |
| Northern Exposure | 1994 | Actress | Miranda at Seven |
| CBS Evening News with Dan Rather and Connie Chung TV Mini Series | 1993 | Actress | Doris Day |
| Quicksand: No Escape | 1992 | Actress | Connie Reinhardt |
| Harley Quinn | 2019–2025 | Producer | executive producer |
| Based on a True Story | 2023–2024 | Producer | executive producer |
| Kite Man: Hell Yeah! | 2024 | Producer | executive producer |
| Role Play | 2024 | Producer | producer |
| Meet Cute | 2022 | Producer | executive producer |
| The Flight Attendant | 2020–2022 | Producer | executive producer |
| Authors Anonymous | 2014 | Producer | executive producer |
| CBS Evening News with Dan Rather and Connie Chung TV Mini Series | 1993 | Producer | executive producer |
| The 38th Annual People's Choice Awards | 2012 | Additional Crew | creative consultant |
| The Tonight Show Starring Jimmy Fallon | 2017 | Soundtrack | performer: "History of Everything" |
| The Big Bang Theory | 2008–2016 | Soundtrack | performer: "Baby" |
| Access Hollywood | 2017–2025 | Self | Self |
| 82nd Golden Globe Awards | 2025 | Self | Self - Presenter |
| Late Night with Seth Meyers | 2016–2024 | Self | Self - Guest |
| The Kelly Clarkson Show | 2019–2024 | Self | Self - Guest |
| Today | 2019–2024 | Self | Self - Guest |
| The Tonight Show Starring Jimmy Fallon | 2015–2024 | Self | Self |
| Entertainment Tonight | 2007–2024 | Self | Self |
| Conan O'Brien Needs a Friend | 2020–2024 | Self | Self |
| The Jennifer Hudson Show | 2024 | Self | Self |
| The 29th Annual Critics' Choice Awards | 2024 | Self | Self - Presenter |
| Jimmy Kimmel Live! | 2004–2024 | Self | Self - Guest |
| Brisant | 2024 | Self | Self |
| Extra | 2015–2023 | Self | Self |
| SmartLess | 2023 | Self | Self - Guest |
| Let's Shoot! with Pete Chatmon TV Series | 2022–2023 | Self | Self |
| The 28th Annual Critics' Choice Awards | 2023 | Self | Self |
| 80th Golden Globe Awards | 2023 | Self | Self - Nominee |
| The 74th Primetime Emmy Awards | 2022 | Self | Self - Nominee |
| The Late Late Show with James Corden | 2015–2022 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2020–2022 | Self | Self - Guest |
| In Creative Company | 2022 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2022 | Self | Self - Guest |
| Good Morning America | 2020–2022 | Self | Self - Guest |
| Hollywood Insider | 2022 | Self | Self |
| DC FanDome 2021 | 2021 | Self | Harley Quinn (voice) |
| The 73rd Primetime Emmy Awards | 2021 | Self | Self - Nominee & Presenter |
| Superstar | 2021 | Self | Self |
| Variety Studio: Actors on Actors | 2017–2021 | Self | Self |
| HBO Max Launch Event Latin America and the Caribbean TV Special | 2021 | Self | Self |
| 27th Annual Screen Actors Guild Awards | 2021 | Self | Self - Nominee |
| 2021 Golden Globe Awards | 2021 | Self | Self - Nominee |
| The Critics' Choice Super Awards | 2021 | Self | Self - Winner |
| Unqualified | 2020 | Self | Self - Guest |
| Armchair Expert with Dax Shepard | 2020 | Self | Self |
| The Cabin with Bert Kreischer | 2020 | Self | Self |
| DC Fandome | 2020 | Self | Self |
| Conan | 2011–2020 | Self | Self - Guest |
| Under a Rock with Tig Notaro | 2019 | Self | Self - Guest |
| The View | 2004–2019 | Self | Self - Guest |
| Star Wars Galaxy's Edge: Adventure Awaits | 2019 | Self | Self |
| Lights Out with David Spade | 2019 | Self | Self - Panelist |
| The Big Bang Theory of Everything | 2019 | Self | Self |
| The Late Show with Stephen Colbert | 2016–2019 | Self | Self - Guest |
| CBS Mornings | 2016–2019 | Self | Self |
| Unraveling the Mystery: A Big Bang Farewell | 2019 | Self | Self - Host |
| The Great Travel Hack | 2019 | Self | Self |
| WGN Morning News | 2019 | Self | Self |
| The Ellen DeGeneres Show | 2004–2019 | Self | Self - Guest |
| The 24th Annual Critics' Choice Awards | 2019 | Self | Self - Presenter |
| E! Live from the Red Carpet | 2014–2019 | Self | Self |
| 2019 Golden Globe Awards | 2019 | Self | Self - Presenter |
| Celebrity Page | 2018 | Self | Self |
| The Talk | 2012–2018 | Self | Self - Guest |
| Behind Closed Doors | 2018 | Self | Self |
| Stand Up To Cancer | 2018 | Self | Self |
| Dish Nation | 2018 | Self | Self |
| The 23rd Annual Critics' Choice Awards | 2018 | Self | Self |
| The Carol Burnett 50th Anniversary Special | 2017 | Self | Self - Guest |
| Extraordinary: Stan Lee Video | 2017 | Self | Self |
| Rachael Ray | 2007–2017 | Self | Self - Guest |
| The Chew | 2015–2017 | Self | Self - Guest |
| The 23rd Annual Screen Actors Guild Awards | 2017 | Self | Self - Presenter |
| The 43rd Annual People's Choice Awards | 2017 | Self | Self - Winner |
| The 22nd Annual Critics' Choice Awards | 2016 | Self | Self |
| Comedy Bang! Bang! | 2016 | Self | Self |
| Must See TV: A Tribute to James Burrows | 2016 | Self | Self |
| The 58th Annual Grammy Awards | 2016 | Self | Self - Presenter |
| 22nd Annual Screen Actors Guild Awards | 2016 | Self | Self - Presenter |
| Lip Sync Battle | 2016 | Self | Self - Competitor |
| Bachelor Live | 2016 | Self | Self - Celebrity Super Fan |
| The 42nd Annual People's Choice Awards | 2016 | Self | Self - Accepting Award |
| All-Star Dog Rescue Celebration | 2015 | Self | Self - Hostess |
| Nickelodeon Kids' Choice Awards 2015 | 2015 | Self | Self (as Kaley Cuoco-Sweeting) |
| Made in Hollywood | 2011–2015 | Self | Self |
| Up Close with Carrie Keagan | 2015 | Self | Self - Guest (as Kaley Cuoco-Sweeting) |
| The Insider | 2014–2015 | Self | Self |
| Unscripted | 2015 | Self | Self (as Kaley Cuoco-Sweeting) |
| Inside Edition | 2014–2015 | Self | Self |
| The 41st Annual People's Choice Awards | 2015 | Self | Self - Winner (as Kaley Cuoco-Sweeting) |
| People Magazine Awards | 2014 | Self | Self (as Kaley Cuoco-Sweeting) |
| Fox's Cause for Paws: An All-Star Dog Spectacular | 2014 | Self | Self (as Kaley Cuoco-Sweeting) |
| E! News | 2014 | Self | Self (as Kaley Cuoco-Sweeting) |
| The Hollywood Reporter Roundtables | 2014 | Self | Self (as Kaley Cuoco-Sweeting) |
| 2014 MTV Movie Awards | 2014 | Self | Self - Cameo #42 |
| Nickelodeon Kids Choice Awards 2014 | 2014 | Self | Self - Presenter |
| Late Show with David Letterman | 2008–2014 | Self | Self - Guest |
| Hollywood Game Night | 2014 | Self | Self - Panelist |
| 20th Annual Screen Actors Guild Awards | 2014 | Self | Self - Presenter (uncredited) |
| 2014 Golden Globe Arrivals Special | 2014 | Self | Self - Interviewee |
| The 40th Annual People's Choice Awards | 2014 | Self | Self - Winner |
| The Late Late Show with Craig Ferguson | 2007–2013 | Self | Self - Guest |
| Teens Wanna Know | 2013 | Self | Self - Guest |
| The 65th Primetime Emmy Awards | 2013 | Self | Self - Presenter |
| Project Runway | 2013 | Self | Self - Guest Judge |
| Guys Choice Awards 2013 | 2013 | Self | Self |
| 48th Annual Academy of Country Music Awards | 2013 | Self | Self |
| Nickelodeon Kids' Choice Awards 2013 | 2013 | Self | Self |
| Iron Chef America: The Series | 2013 | Self | Self - ICA Judge |
| The 55th Annual Grammy Awards | 2013 | Self | Self - Presenter |
| 70th Golden Globe Awards | 2013 | Self | Self - Presenter |
| The 39th Annual People's Choice Awards | 2013 | Self | Self - Host |
| Comic Con 2012 Live | 2012 | Self | Self |
| The 26th Annual Genesis Awards | 2012 | Self | Self - Presenter |
| The Big Bang Theory: It All Started with a Big Bang | 2012 | Self | Self |
| The Big Bang Theory: Access All Areas | 2012 | Self | Self |
| The 38th Annual People's Choice Awards | 2012 | Self | Self - Host & Nominee |
| Chelsea Lately | 2010–2012 | Self | Self - Guest |
| Live with Kelly and Mark | 2011 | Self | Self - Guest |
| The 63rd Primetime Emmy Awards | 2011 | Self | Self - Presenter |
| Teen Choice 2011 | 2011 | Self | Self - Hostess |
| The 1st Annual Critics' Choice Television Awards | 2011 | Self | Self |
| 100 Sexiest Videos of All Time | 2011 | Self | Self |
| Lopez Tonight | 2011 | Self | Self - Guest |
| Nickelodeon's Kids Choice Awards 2011 | 2011 | Self | Self |
| Piper's Picks TV | 2011 | Self | Self - Guest |
| Piper's QUICK Picks | 2011 | Self | Self - Guest |
| The 68th Annual Golden Globe Awards | 2011 | Self | Self - Presenter |
| The 37th Annual People's Choice Awards | 2011 | Self | Self |
| The 2010 American Country Awards | 2010 | Self | Self |
| The Big Bang Theory: Take Out with the Cast of the Big Bang Theory | 2010 | Self | Self |
| The 52nd Annual Grammy Awards | 2010 | Self | Self |
| The 36th Annual People's Choice Awards | 2010 | Self | Self |
| The Wendy Williams Show | 2009 | Self | Self - Guest |
| Scream Awards 2009 | 2009 | Self | Self |
| The 61st Primetime Emmy Awards | 2009 | Self | Self - Presenter |
| The Big Bang Theory: Testing the Infinite Hilarity Hyphothesis of the Big Bang Theory | 2009 | Self | Self |
| The Big Bang Theory: Physicist to the Stars | 2009 | Self | Self |
| Last Call with Carson Daly | 2008–2009 | Self | Self - Guest |
| 44th Annual Academy of Country Music Awards | 2009 | Self | Self |
| 23rd Annual Genesis Awards TV Special | 2009 | Self | Self |
| The Bonnie Hunt Show | 2009 | Self | Self |
| The 22nd Annual Genesis Awards TV Special | 2008 | Self | Self |
| The Big Bang Theory: Quantum Mechanics of the Big Bang Theory | 2008 | Self | Self |
| The Philanthropist | 2008 | Self | Self (uncredited) |
| 43rd Annual Academy of Country Music Awards | 2008 | Self | Self |
| CBS Mornings | 2007 | Self | Self - Guest |
| Your Mommy Kills Animals! | 2007 | Self | Self - Actress |
| The Making of, Debating Robert Lee Short | 2006 | Self | Self |
| E! True Hollywood Story | 2005 | Self | Self |
| Pet Star | 2005 | Self | Celebrity Judge #1 |
| 11th Annual Screen Actors Guild Awards | 2005 | Self | Self |
| The Late Late Show with Craig Kilborn | 2004 | Self | Self - Guest |
| 2004 Much Music Video Music Awards | 2004 | Self | Self |
| Punk'd | 2004 | Self | Self |
| Hollywood Squares | 2004 | Self | Self - Panelist |
| The Sharon Osbourne Show | 2004 | Self | Self - Guest |
| Larry King Live | 2004 | Self | Self - Guest |
| The 30th Annual People's Choice Awards | 2004 | Self | Self |
| VH1 Big in 03 | 2003 | Self | Self |
| A Life of Laughter: Remembering John Ritter | 2003 | Self | Self |
| The Teen Choice Awards 2003 | 2003 | Self | Self |
| The 17th Annual Genesis Awards TV Special | 2003 | Self | Self - Presenter |
| Nickelodeon Kids' Choice Awards '03 | 2003 | Self | Self |
| The 29th Annual People's Choice Awards | 2003 | Self | Self |
| Don't Forget Your Toothbrush | 2000 | Self | Ashley (2000) |
| Entertainment Tonight | 2009–2025 | Archive Footage | Self (archive footage) |
| Bob Newhart: A Legacy of Laughter | 2024 | Archive Footage | Self (archive footage) |
| Superpowered: The DC Story | 2023 | Archive Footage | Self - Actor, Harley Quinn (archive footage) |
| Access Hollywood | 2019–2023 | Archive Footage | Self (archive footage) |
| Titans | 2023 | Archive Footage | Harley Quinn (archive footage) |
| The Kelly Clarkson Show | 2022 | Archive Footage | Self (archive footage) |
| Inside Edition | 2014–2021 | Archive Footage | Self (archive footage) |
| History of the Sitcom | 2021 | Archive Footage | Penny Hofstadter (archive footage) |
| Celebrity Page | 2018 | Archive Footage | Self (archive footage) |
| Extra | 2015–2018 | Archive Footage | Self (archive footage) |
| taff | 2013–2017 | Archive Footage | Self (archive footage) |
| The Insider | 2017 | Archive Footage | Self (archive footage) |
| For the Love of Spock | 2016 | Archive Footage | Penny (archive footage, uncredited) |
| The Tonight Show with Jay Leno | 2012 | Archive Footage | Self (archive footage, uncredited) |
| 15 Unforgettable Hollywood Tragedies TV Movie | 2009 | Archive Footage | Self (archive footage) |