| The Hoarding | 2020 | Director | Director |
| The Party's Just Beginning | 2018 | Director | Director |
| Conventional | 2015 | Director | Director |
| Fun Size Horror: Volume Two | 2015 | Director | Director (segment "Conventional") |
| Coward | 2015 | Director | Director |
| The Hoarding | 2020 | Writer | Writer |
| The Party's Just Beginning | 2018 | Writer | screenplay |
| Conventional | 2015 | Writer | written by |
| Fun Size Horror: Volume Two | 2015 | Writer | Writer (segment "Conventional") |
| Coward | 2015 | Writer | Writer |
| What If...? | 2021–2024 | Actress | Nebula (voice) |
| The Life of Chuck | 2024 | Actress | Felicia Gordon |
| Douglas Is Cancelled | 2024 | Actress | Madeline |
| Sleeping Dogs | 2024 | Actress | Laura Baines |
| The Simpsons | 2023 | Actress | Maisie MacWeldon (voice) |
| Guardians of the Galaxy Vol. 3 | 2023 | Actress | Nebula |
| Late Bloomers | 2023 | Actress | Louise |
| The Guardians of the Galaxy Holiday Special | 2022 | Actress | Nebula |
| Thor: Love and Thunder | 2022 | Actress | Nebula |
| Next Exit | 2022 | Actress | Dr. Stevensen |
| The Bubble | 2022 | Actress | Carol Cobb |
| Dual | 2022 | Actress | Sarah |
| Gunpowder Milkshake | 2021 | Actress | Sam |
| Calls | 2021 | Actress | Sara (voice) |
| The Hoarding | 2020 | Actress | Hope |
| Rory's Story | 2020 | Actress | Amy (voice) |
| The Call of the Wild | 2020 | Actress | Mercedes |
| Jumanji: The Next Level | 2019 | Actress | Ruby |
| Spies in Disguise | 2019 | Actress | Eyes (voice) |
| Eureka! | 2019 | Actress | Chloe |
| Neurotica. | 2019 | Actress | Chloe |
| Avengers: Endgame | 2019 | Actress | Nebula |
| Stuber | 2019 | Actress | Sara Morris |
| All Creatures Here Below | 2018 | Actress | Ruby |
| Avengers: Infinity War | 2018 | Actress | Nebula |
| The Party's Just Beginning | 2018 | Actress | Liusaidh |
| Nick Jonas & Jack Black: Jumanji Jumanji | 2017 | Actress | Karen Gillan |
| Jumanji: Welcome to the Jungle | 2017 | Actress | Martha |
| Alex & The List | 2017 | Actress | Lily |
| Guardians of the Galaxy: Inferno | 2017 | Actress | Karen Gillan |
| The Circle | 2017 | Actress | Annie |
| Guardians of the Galaxy Vol. 2 | 2017 | Actress | Nebula |
| Emo Dad | 2016 | Actress | Jessica |
| In a Valley of Violence | 2016 | Actress | Ellen |
| The Devil You Know | 2015 | Actress | Jane Porter |
| Robot Chicken | 2015 | Actress | Anastasia Steele |
| The Big Short | 2015 | Actress | Evie |
| Conventional | 2015 | Actress | Rachel |
| Fun Size Horror: Volume Two | 2015 | Actress | Rachel Milligan (segment "Conventional") |
| Warning Labels | 2015 | Actress | Mindy |
| 7 Days in Hell | 2015 | Actress | Lily Allsworth |
| Selfie | 2014 | Actress | Eliza Dooley |
| Halloween video of the Selfie cast (Karen Gillan and John Cho dressed up as Power Rangers) | 2014 | Actress | Pink Ranger Karen |
| TV on the Radio: Happy Idiot | 2014 | Actress | Jennifer |
| Bound for Greatness | 2014 | Actress | Maeve MacDonough |
| A Touch of Cloth | 2014 | Actress | Kerry Newblood |
| Guardians of the Galaxy | 2014 | Actress | Nebula |
| Z'ombeal: Walking Dead Skin Care | 2013 | Actress | Zombie |
| Doctor Who | 2008–2013 | Actress | Amy Pond |
| NTSF:SD:SUV | 2013 | Actress | Daisy |
| Oculus | 2013 | Actress | Kaylie Russell |
| Not Another Happy Ending | 2013 | Actress | Jane Lockhart |
| In Love With... | 2012 | Actress | Laura |
| Pond Life | 2012 | Actress | Amy Pond (uncredited) |
| Doctor Who: Good as Gold | 2012 | Actress | Amy Pond |
| We'll Take Manhattan | 2012 | Actress | Jean Shrimpton |
| Night and the Doctor | 2011 | Actress | Amy Pond (uncredited) |
| Doctor Who: The Adventure Games - The Gunpowder Plot | 2011 | Actress | Amy Pond (voice) |
| Doctor Who: Prequel to Let's Kill Hitler | 2011 | Actress | Amy Pond (voice, uncredited) |
| Doctor Who: Space and Time | 2011 | Actress | Amy Pond |
| Doctor Who: The Adventure Games - Shadows of the Vashta Nerada | 2010 | Actress | Amy Pond (voice) |
| Doctor Who: Return to Earth | 2010 | Actress | Amy Pond (voice) |
| Doctor Who: Evacuation Earth | 2010 | Actress | Amy Pond (voice) |
| Meanwhile, in the TARDIS: Part 2 | 2010 | Actress | Amy Pond |
| Meanwhile, in the TARDIS: Part 1 | 2010 | Actress | Amy Pond |
| Doctor Who: The Adventure Games - TARDIS | 2010 | Actress | Amy Pond (voice) |
| Doctor Who: The Adventure Games - Blood of the Cybermen | 2010 | Actress | Amy Pond (voice) |
| Doctor Who: The Adventure Games - City of the Daleks | 2010 | Actress | Amy Pond (voice) |
| Outcast | 2010 | Actress | Ally |
| The Well | 2009 | Actress | Coll |
| The Kevin Bishop Show | 2008–2009 | Actress | Various Characters |
| New Town Killers | 2008 | Actress | Young Girl in Bus Station |
| Stacked | 2008 | Actress | Ginny Turner |
| Coming Up | 2008 | Actress | Anna |
| Harley Street | 2008 | Actress | Holly |
| Rebus | 2006 | Actress | Teri Cotter |
| Coward | 2015 | Producer | executive producer |
| MPower | 2023 | Additional Crew | archival sources |
| X | 2022 | Thanks | special thanks |
| Collection | 2021 | Thanks | special thanks |
| Doctor Who: The Ultimate Guide | 2010 | Thanks | special thanks |
| Late Bloomers | 2023 | Soundtrack | performer: "Listen, Listen" |
| The Bubble | 2022 | Soundtrack | performer: "Close to You", "Out Here on My Own" |
| The Tonight Show Starring Jimmy Fallon | 2019 | Soundtrack | performer: "We Didn't Start the Fire" |
| Selfie | 2014 | Soundtrack | performer: "Chandelier" |
| Variety Studio | 2024 | Self | Self - Guest |
| The One Show | 2010–2024 | Self | Self |
| Made in Hollywood | 2014–2024 | Self | Self |
| Front Row Flynn | 2024 | Self | Self |
| In Creative Company | 2024 | Self | Self |
| Mythical Kitchen | 2024 | Self | Self |
| Last Meals | 2024 | Self | Self |
| The 28th Annual Art Directors Guild Awards TV Special | 2024 | Self | Self - Presenter |
| Marvel Studios: Assembled | 2022–2023 | Self | Self - Nebula |
| Conference Call Podcast Series | 2023 | Self | Self |
| Entertainment Tonight | 2014–2023 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2023 | Self | Self - Guest |
| How Well Do You Know Your IMDb Page? | 2021–2023 | Self | Self - Guest |
| The View | 2014–2023 | Self | Self |
| D23 Inside Disney Podcast Series | 2023 | Self | Self - Guest |
| Live with Kelly and Mark | 2023 | Self | Self - Guest |
| Good Morning America | 2014–2023 | Self | Self - Guest |
| MMTG | 2023 | Self | Self - Guest |
| Burning Questions | 2023 | Self | Self |
| MPower | 2023 | Self | Self - Nebula |
| The Talk | 2022 | Self | Self |
| Life is Short with Justin Long | 2022 | Self | Self - Guest |
| Celebrity Page | 2017–2022 | Self | Self |
| IMDb Originals | 2022 | Self | Self - Guest |
| Girls on Film | 2021 | Self | Self (voice) |
| That One Audition Podcast Series | 2021 | Self | Self |
| GMA3: What You Need to Know | 2021 | Self | Self |
| Unspooled | 2021 | Self | Self - Guest |
| Jimmy Kimmel Live! | 2014–2021 | Self | Self |
| Celebrity Game Face | 2020 | Self | Self - Contestant |
| Hollywood Insider | 2019–2020 | Self | Self |
| A Little Late with Lilly Singh | 2020 | Self | Self |
| This Week in Marvel Podcast Series | 2019 | Self | Self |
| Celebrating Marvel's Stan Lee | 2019 | Self | Self |
| The Kelly Clarkson Show | 2019 | Self | Self |
| Jablinski Games | 2019 | Self | Self |
| Orange Carpet Special Edition | 2017–2019 | Self | Self |
| Celebrity Interviews TV Series | 2019 | Self | Self |
| The Chris Moyles Show on Radio X | 2019 | Self | Self |
| Larry King Now | 2019 | Self | Self - Guest |
| IMDb LIVE at the Jumanji: The Next Level Premiere | 2019 | Self | Self (2019) |
| Lorraine | 2019 | Self | Self - Guest |
| WatchMojo | 2019 | Self | Self |
| The E! People's Choice Awards | 2019 | Self | Self - Presenter |
| Marvel Studios' Avengers: Endgame LIVE Red Carpet World Premiere | 2019 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2019 | Self | Self - Performer |
| Gary Goes to Hollywood TV Movie | 2018 | Self | Self |
| GMA3: What You Need to Know | 2018 | Self | Self |
| The Blake & Sal Show Podcast Series | 2018 | Self | Self - Panelist |
| Inside of You with Michael Rosenbaum | 2018 | Self | Self |
| The EE British Academy Film Awards | 2018 | Self | Self - Presenter |
| Dish Nation | 2017 | Self | Self |
| Good Morning Britain | 2017 | Self | Self - Actress |
| Bonus Round: The Making of 'Guardians of the Galaxy Vol. 2' | 2017 | Self | Self |
| Extraordinary: Stan Lee Video | 2017 | Self | Self |
| Happy Sad Confused | 2017 | Self | Self |
| Seven Bucks Digital Studios | 2017 | Self | Self |
| Comedy Bang! Bang! | 2015 | Self | Self |
| TableTop | 2015 | Self | Self - Guest |
| Quiet on the Set | 2014–2024 | Self | Self (as Karen Gillian) |
| The Insider | 2014 | Self | Self - Selfie |
| The Real History of Science Fiction | 2014 | Self | Self |
| Calgary Expo 2014 Short | 2014 | Self | Self |
| Reel Junkie | 2014 | Self | Self |
| Doctor Who: Farewell to Matt Smith | 2013 | Self | Self - Amy Pond |
| Doctor Who Live: The Afterparty | 2013 | Self | Self (uncredited) |
| Doctor Who: The Ultimate Guide | 2013 | Self | Self |
| Doctor Who: Tales from the TARDIS | 2013 | Self | Self - Amy Pond |
| Doctor Who: The Doctors Revisited | 2013 | Self | Self |
| The Late Late Show with Craig Ferguson | 2011–2013 | Self | Self - Guest |
| The Nerdist | 2013 | Self | Self |
| Doctor Who: The Companions | 2013 | Self | Self |
| Doctor Who in the U.S. | 2012 | Self | Self |
| Conan | 2012 | Self | Self - Guest |
| Chris Hardwick's All-Star Celebrity Bowling | 2012 | Self | Self |
| The Science of Doctor Who | 2012 | Self | Self |
| Comic Con 2012 Live | 2012 | Self | Self |
| National Television Awards: The Party TV Special | 2012 | Self | Self |
| National Television Awards | 2012 | Self | Self |
| The Graham Norton Show | 2010–2012 | Self | Self - Guest |
| Doctor Who Confidential | 2010–2011 | Self | Self |
| Children in Need | 2011 | Self | Self |
| Breakfast | 2010–2011 | Self | Self - Actress |
| Paul O'Grady Live | 2011 | Self | Self |
| Doctor Who in America | 2011 | Self | Self |
| Comic Relief: Red Nose Day 2011 | 2011 | Self | Amy Pond |
| Children in Need 2010 | 2010 | Self | Self |
| Daybreak | 2010 | Self | Self |
| BBC Proms | 2010 | Self | Self - Host |
| Doctor Who: The Ultimate Guide | 2010 | Self | Self |
| GMTV | 2010 | Self | Self |
| The Passions of... Girls Aloud | 2008 | Self | Self - Model |
| Doctor Who: Unleashed | 2023–2024 | Archive Footage | Amy Pond (archive footage) |
| Nerdrotic | 2023 | Archive Footage | Self (archive footage) |
| Marvel Studios: Legends | 2021–2023 | Archive Footage | Nebula (archive footage, uncredited) |
| Sunday Today with Willie Geist | 2022 | Archive Footage | Nebula (archive footage) |
| Doctor Who | 2017–2020 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Jablinski Games | 2019 | Archive Footage | Self (archive footage, uncredited) |
| No Small Parts | 2019 | Archive Footage | Self (archive footage) |
| The Chris Moyles Show on Radio X | 2019 | Archive Footage | Nebula (archive footage) |
| Heroes Manufactured | 2016 | Archive Footage | Self (archive footage) |
| The Ultimate Time Lord | 2014 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Doctor Who: The Ultimate Companion | 2014 | Archive Footage | Amy Pond (archive footage, uncredited) |
| The Culture Show | 2013 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Doctor Who Live: The Next Doctor | 2013 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Newsround | 2013 | Archive Footage | Amy Pond (archive footage) |
| Being a Girl | 2013 | Archive Footage | Amy Pond (archive footage, uncredited) |
| The Big Fat Quiz of the Year | 2012 | Archive Footage | Amy Pond (archive footage, uncredited) |
| The Destinations of Doctor Who | 2012 | Archive Footage | Amelia Pond (archive footage) |
| The Timey-Wimey of Doctor Who | 2012 | Archive Footage | Amy Pond (archive footage, uncredited) |
| The Women of Doctor Who | 2012 | Archive Footage | Amy Pond (archive footage, uncredited) |
| The Graham Norton Show | 2012 | Archive Footage | Self (archive footage) |
| Best of the Companions TV Special | 2011 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Best of the Monsters | 2011 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Best of the Doctor TV Special | 2011 | Archive Footage | Amy Pond (archive footage, uncredited) |
| Phelous & the Movies | 2011 | Archive Footage | Amy Pond (archive footage) |
| Almost Famous IV | 2011 | Archive Footage | Soothsayer (archive footage) |
| Doctor Who | 2013 | Archive Sound | Amy Pond (archive footage, uncredited) |