| The Dutchman | 2025 | Actress | Lula |
| The Astronaut | 2025 | Actress | Capt. Sam Walker |
| Invincible | 2025 | Actress | Becky (voice) |
| Friendship | 2024 | Actress | Tami |
| Murder in HR | 2023 | Actress | Jemma |
| Class of '09 | 2023 | Actress | Ashley Poet |
| Black Mirror | 2023 | Actress | Lana Stanfield |
| Koz | 2022 | Actress | Becky Kozlowski (as Kate Mara Bell) |
| The Big Lie | 2022 | Actress | Honor Bergin |
| Call Jane | 2022 | Actress | Lana |
| Ghostwriter | 2021 | Actress | Kate (voice) |
| A Teacher | 2020 | Actress | Claire Wilson |
| Time of Day | 2018 | Actress | Kate Mara |
| Pose | 2018 | Actress | Patty Bowes |
| Why Can't We Get Along | 2018 | Actress | Kate Mara |
| Chappaquiddick | 2017 | Actress | Mary Jo Kopechne |
| My Days of Mercy | 2017 | Actress | Mercy |
| Tall Tales from the Magical Garden of Antoon Krings | 2017 | Actress | Marguerite (English version, voice) |
| Megan Leavey | 2017 | Actress | Megan Leavey |
| Morgan | 2016 | Actress | Lee Weathers |
| House of Cards | 2013–2016 | Actress | Zoe Barnes |
| Moonbeam City | 2015 | Actress | Chrysalis Tate (voice) |
| Captive | 2015 | Actress | Ashley Smith |
| The Martian | 2015 | Actress | Beth Johanssen |
| Man Down | 2015 | Actress | Natalie Drummer |
| Ares III: The Right Stuff | 2015 | Actress | Beth Johanssen |
| Fantastic Four | 2015 | Actress | Sue Storm |
| Ares III: Farewell | 2015 | Actress | Beth Johanssen |
| The Heyday of the Insensitive Bastards | 2015 | Actress | Lisa |
| Almost Not Beautiful | 2014 | Actress | Lisa |
| Tiny Detectives | 2014 | Actress | Detective Kate |
| Robot Chicken | 2014 | Actress | Raspberry Parfait |
| Transcendence | 2014 | Actress | Bree |
| Broken Bells: Holding on for Life | 2013 | Actress | Girl |
| Broken Bells: After the Disco | 2013 | Actress | Girl |
| Tron: Uprising | 2012 | Actress | Perl (voice) |
| Deadfall | 2012 | Actress | Hanna Becker |
| American Horror Story | 2011 | Actress | Hayden McClaine |
| 10 Years | 2011 | Actress | Elise |
| Queen of Hearts | 2011 | Actress | Queen of Hearts |
| 127 Hours: Deleted Scenes | 2011 | Actress | Kristi |
| Ironclad | 2011 | Actress | Lady Isabel |
| Peep World | 2010 | Actress | Meg |
| 127 Hours | 2010 | Actress | Kristi |
| Iron Man 2 | 2010 | Actress | U.S. Marshal |
| Happythankyoumoreplease | 2010 | Actress | Mississippi |
| Big Guy | 2009 | Actress | Kate |
| Entourage | 2009 | Actress | Brittany |
| The Open Road | 2009 | Actress | Lucy |
| T Takes: Brooklyn '09 Episode 4 | 2009 | Actress | Kate |
| T Takes: Brooklyn '09 Episode 1 | 2009 | Actress | Kate |
| Stone of Destiny | 2008 | Actress | Kay Matheson |
| Transsiberian | 2008 | Actress | Abby |
| Shooter | 2007 | Actress | Sarah Fenn |
| Full of It | 2007 | Actress | Annie Dray |
| We Are Marshall | 2006 | Actress | Annie Cantrell |
| Fireflies | 2006 | Actress | Taylor |
| Zoom | 2006 | Actress | Summer Jones |
| 24 | 2006 | Actress | Shari Rothenberg |
| The Californians | 2005 | Actress | Zoe Tripp |
| Brokeback Mountain | 2005 | Actress | Alma Jr., Age 19 |
| Urban Legends: Bloody Mary | 2005 | Actress | Samantha Owens |
| Jack & Bobby | 2005 | Actress | Katie |
| Prodigy | 2004 | Actress | Callie Duncan |
| CSI: Crime Scene Investigation | 2004 | Actress | Janelle Macklin |
| CSI: Miami | 2004 | Actress | Stephanie Brooks |
| Time Well Spent | 2004 | Actress | Girl |
| Boston Public | 2003 | Actress | Helena Gelbke |
| Cold Case | 2003 | Actress | Jill Shelby |
| Nip/Tuck | 2003 | Actress | Vanessa Bartholomew |
| Everwood | 2003 | Actress | Kate Morris |
| Tadpole | 2002 | Actress | Miranda Spear |
| Law & Order: Special Victims Unit | 2001 | Actress | Lori |
| Madigan Men | 2000 | Actress | Julie |
| Ed | 2000 | Actress | Kelly Kovacs |
| Random Hearts | 1999 | Actress | Jessica Chandler |
| Joe the King | 1999 | Actress | Allyson |
| Law & Order | 1997 | Actress | Jenna Erlich |
| The Dutchman | 2025 | Producer | executive producer |
| The Smell of Money | 2022 | Producer | executive producer |
| Ghostwriter | 2021 | Producer | executive producer |
| A Teacher | 2020 | Producer | executive producer |
| My Days of Mercy | 2017 | Producer | producer |
| The One I Love | 2014 | Thanks | thank you (as The Mara Family) |
| The Tonight Show Starring Jimmy Fallon | 2015 | Soundtrack | performer: "Walk Like an Egyptian" |
| 10 Years | 2011 | Soundtrack | performer: "You Ain't Going Nowhere" |
| Happythankyoumoreplease | 2010 | Soundtrack | performer: "Sing Happy" |
| The Californians | 2005 | Soundtrack | performer: "The Californians", "Mother Nature" (original title: "Deep Green"), "The Right Idea", "Radical Approach", "Will You See Me Home", "I Don't Know Why (I Just Do)", "Little Boxes" |
| Ed | 2000 | Soundtrack | performer: "There's No Business Like Show Business" |
| Mercy for Animals 25th Anniversary Gala | 2024 | Self | Self - Honoree |
| Mercy for Animals 25th Anniversary Gala: Red Carpet Short | 2024 | Self | Self |
| IMDb Interviews | 2023 | Self | Self |
| Today | 2015–2023 | Self | Self - Guest |
| The Kelly Clarkson Show | 2023 | Self | Self - Guest |
| American Football: How the Gridiron Was Forged Podcast Series | 2022 | Self | Self |
| Hollywood Insider | 2022 | Self | Self |
| In Creative Company | 2021 | Self | Self |
| Hudi the Foodie Podcast Series | 2021 | Self | Self |
| The Drew Barrymore Show | 2020 | Self | Self - Guest |
| GMA3: What You Need to Know | 2020 | Self | Self |
| The Ellen DeGeneres Show | 2014–2020 | Self | Self |
| Unqualified | 2020 | Self | Self - Guest |
| Collider Ladies Night | 2020 | Self | Self - Guest |
| Good Morning America | 2017–2020 | Self | Self - Guest |
| Tamron Hall | 2020 | Self | Self |
| Live with Kelly and Mark | 2013–2020 | Self | Self - Guest |
| The Tonight Show Starring Jimmy Fallon | 2015–2020 | Self | Self - Guest |
| Informed Pregnancy Podcast | 2019 | Self | Self |
| Celebrity Page | 2017–2018 | Self | Self |
| Conan | 2016–2018 | Self | Self - Guest |
| Pose: Identity, Family, Community | 2018 | Self | Self |
| Extra | 2018 | Self | Self |
| Entertainment Tonight | 2014–2018 | Self | Self |
| The British Academy Britannia Awards TV Special | 2017 | Self | Self - Presenter |
| Popcorn with Peter Travers | 2017 | Self | Self - Guest |
| The Talk | 2017 | Self | Self - Guest |
| The Late Late Show with James Corden | 2016–2017 | Self | Self - Guest |
| Made in Hollywood | 2011–2017 | Self | Self |
| WGN Morning News | 2017 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2017 | Self | Self |
| The Long Way Home: Making the Martian | 2016 | Self | Self |
| 14th Annual VES Awards | 2016 | Self | Self |
| E! Live from the Red Carpet | 2015–2016 | Self | Self |
| Occupy Mars: Casting and Costumes of 'the Martian' | 2016 | Self | Self |
| Powering Up: Superpowers of the 'Fantastic Four' | 2015 | Self | Self |
| Jimmy Kimmel Live! | 2007–2015 | Self | Self - Guest |
| Variety Studio | 2015 | Self | Self |
| taff | 2015 | Self | Self |
| Huffpost Live | 2015 | Self | Self |
| Weekend Ticket | 2015 | Self | Self |
| Fox and Friends | 2015 | Self | Self |
| The 39th Annual Women in Film Crystal & Lucy Awards TV Special | 2015 | Self | Self - Recipient |
| 2015 MTV Movie Awards | 2015 | Self | Self - Presenter |
| 2014 Primetime Creative Arts Emmy Awards | 2014 | Self | Self - Nominee |
| House of Cards: Politics for the Sake of Politics | 2014 | Self | Self |
| House of Cards: The Direct Address | 2014 | Self | Self |
| The 68th Annual Tony Awards | 2014 | Self | Self - Presenter |
| Up Close with Carrie Keagan | 2007–2014 | Self | Self - Guest |
| Red Carpet Report | 2014 | Self | Self |
| Late Show with David Letterman | 2014 | Self | Self - Guest |
| The Hollywood Reporter Emmy Roundtable | 2013 | Self | Self |
| The Hour | 2013 | Self | Self - Guest |
| Last Call with Carson Daly | 2013 | Self | Self - Guest |
| Late Night with Jimmy Fallon | 2013 | Self | Self - Guest |
| Chelsea Lately | 2013 | Self | Self - Guest |
| Out of the Shadows: Meet the House Ghosts Video | 2012 | Self | Self |
| MSN Exclusives | 2012 | Self | Self (2014) |
| 17th Annual Screen Actors Guild Awards | 2011 | Self | Self |
| The Late Late Show with Craig Ferguson | 2008–2010 | Self | Self - Guest |
| The Making of 'Transsiberian' Video | 2008 | Self | Self |
| Survival of the Fittest: The Making of 'Shooter' | 2007 | Self | Self |
| Weekend Sunrise | 2007 | Self | Self |
| Late Night with Conan O'Brien | 2007 | Self | Self - Guest |
| Bringing Superheroes to Life: The Making of 'Zoom' Video | 2007 | Self | Self |
| MovieReal: We Are Marshall | 2006 | Self | Self |
| Fuse Celebrity Playlist | 2006 | Self | Self - Guest |
| Netflix vs. the World | 2019 | Archive Footage | Self (archive footage) |
| Celebrity Page | 2018–2019 | Archive Footage | Self (archive footage) |
| The Ben Shapiro Show | 2017 | Archive Footage | Self (archive footage) |
| Ares III: The Untold Story | 2016 | Archive Footage | Beth Johanssen (archive footage) |
| Lennon or McCartney | 2014 | Archive Footage | Self (archive footage) |
| House of Cards | 2014 | Archive Footage | Zoe Barnes (archive footage, uncredited) |