| The Buccaneers | 2025 | Actress | Nelle |
| Good Cop/Bad Cop | 2025 | Actress | Lou Hickman |
| EXmas | 2023 | Actress | Ali Moyer |
| River Wild | 2023 | Actress | Joey |
| How I Met Your Father | 2022–2023 | Actress | Meredith |
| My Father's Dragon | 2022 | Actress | Sasha (voice) |
| The Orville | 2019–2022 | Actress | Laura Huggins |
| The Weekend Away | 2022 | Actress | Beth |
| Killer Movie: Director's Cut | 2021 | Actress | Jaynie Hansen |
| Single Parents | 2018–2020 | Actress | Angie D'Amato |
| Semper Fi | 2019 | Actress | Clara |
| The North Wind's Gift | 2018 | Actress | |
| The Last Man on Earth | 2018 | Actress | Zoe |
| Making History | 2017 | Actress | Deborah Revere |
| Any Tom, Dick, or Harry | 2015 | Actress | Barbara |
| Entrevista a Leighton Meester Video | 2014 | Actress | |
| Leighton Meester: Heartstrings | 2014 | Actress | Leighton Meester |
| By the Gun | 2014 | Actress | Ali Matazano |
| Like Sunday, Like Rain | 2014 | Actress | Eleanor |
| The Judge | 2014 | Actress | Carla Powell |
| Life Partners | 2014 | Actress | Sasha |
| Of Mice and Men | 2014 | Actress | Curley's Wife |
| Gossip Girl | 2007–2012 | Actress | Blair Waldorf |
| Nomads: Addicted to Love | 2012 | Actress | Woman on Date |
| That's My Boy | 2012 | Actress | Jamie |
| The Oranges | 2011 | Actress | Nina |
| Monte Carlo | 2011 | Actress | Meg |
| The Roommate | 2011 | Actress | Rebecca |
| Country Strong | 2010 | Actress | Chiles Stanton |
| Going the Distance | 2010 | Actress | Amy |
| Date Night | 2010 | Actress | Katy |
| Leighton Meester: Somebody to Love | 2009 | Actress | Leighton Meester |
| Cobra Starship: Good Girls Go Bad | 2009 | Actress | Leighton Meester |
| Entourage | 2004–2008 | Actress | Justine Chapin |
| Killer Movie | 2008 | Actress | Jaynie Hansen |
| The Haunting of Sorority Row | 2007 | Actress | Samantha Willows |
| Remember the Daze | 2007 | Actress | Tori |
| Shark | 2007 | Actress | Megan |
| Drive Thru | 2007 | Actress | Mackenzie Carpenter |
| CSI: Miami | 2007 | Actress | Heather Crowley |
| Secrets of a Small Town | 2006 | Actress | Kayla Rhodes |
| House | 2006 | Actress | Ali |
| Surface: Behind the Scenes Featurette | 2006 | Actress | Savannah Barnett |
| Numb3rs | 2006 | Actress | Karen Camden |
| Inside | 2006 | Actress | Josie |
| Flourish | 2006 | Actress | Lucy Covner |
| Surface | 2005–2006 | Actress | Savannah Barnett |
| Monster Allergy | 2005 | Actress | Poppy (voice) |
| Veronica Mars | 2005 | Actress | Carrie Bishop |
| 8 Simple Rules | 2005 | Actress | Nikki |
| 24 | 2005 | Actress | Debbie Pendleton |
| Hollywood Division | 2004 | Actress | Michelle |
| North Shore | 2004 | Actress | Veronica Farrell |
| 7th Heaven | 2004 | Actress | Kendall |
| Crossing Jordan | 2004 | Actress | Marie Strand |
| The Big Wide World of Carl Laemke | 2003 | Actress | Tanni |
| Tarzan | 2003 | Actress | Nicki Porter |
| Hangman's Curse | 2003 | Actress | Elisha Springfield |
| The Jackalope | 2003 | Actress | Lorraine |
| Family Affair | 2002 | Actress | Irene |
| Once and Again | 2002 | Actress | Amanda |
| Boston Public | 2001 | Actress | Sarah Breen |
| Law & Order | 1999 | Actress | Alyssa Turner |
| The Kid Detective | 2020 | Thanks | very special thanks |
| Gossip Girl: XO XO | 2012 | Thanks | special thanks |
| Single Parents | 2018–2020 | Soundtrack | performer: "Genie in a Bottle" |
| The Orville | 2019 | Soundtrack | performer: "That's All I've Got to Say" |
| Weepah Way for Now | 2015 | Soundtrack | performer: "Good for One Thing", "Entitled" |
| Law & Order: Special Victims Unit | 2015 | Soundtrack | performer: "Good Girls Go Bad" |
| Big Morning Buzz Live | 2014 | Soundtrack | performer: "Heartstrings" |
| Watch Dogs | 2014 | Soundtrack | performer: "Good Girls Go Bad" |
| Boyhood | 2014 | Soundtrack | performer: "Good Girls Go Bad" |
| Hart of Dixie | 2011 | Soundtrack | performer: "Good Girls Go Bad" |
| Country Strong | 2010 | Soundtrack | performer: "Friends in Low Places", "Summer Girl", "Words I Couldn't Say", "Coming Home", "Give In To Me", "A Little Bit Stronger" |
| Gossip Girl | 2009–2010 | Soundtrack | performer: "Your Love's a Drug" |
| How to Make It in America | 2010 | Soundtrack | performer: "Good Girls Go Bad" |
| Valentine's Day | 2010 | Soundtrack | performer: "Somebody to Love" |
| It's on with Alexa Chung | 2009 | Soundtrack | performer: "Somebody to Love" |
| Greek | 2009 | Soundtrack | performer: "Good Girls Go Bad" |
| Ugly Betty | 2009 | Soundtrack | performer: "Good Girls Go Bad" |
| So You Think You Can Dance | 2009 | Soundtrack | performer: "Good Girls Go Bad" (uncredited) |
| Entourage | 2008 | Soundtrack | performer: "The Good Life" (La Belle Vie) (uncredited) |
| Drive Thru | 2007 | Soundtrack | performer: "Inside The Black" |
| The 31st Annual Screen Actors Guild Awards | 2025 | Self | Self - Audience Member |
| The 30th Annual Critics' Choice Awards | 2025 | Self | Self - Audience Member |
| 82nd Golden Globe Awards | 2025 | Self | Self - Audience Member |
| Podcrushed | 2022 | Self | Self - Guest |
| Celebrity Page | 2018–2022 | Self | Self |
| Made in Hollywood | 2010–2022 | Self | Self |
| Hollywood Insider | 2020–2021 | Self | Self |
| Entertainment Tonight | 2007–2020 | Self | Self |
| Lights Out with David Spade | 2019 | Self | Self - Panelist |
| Entertainment Tonight Canada | 2019 | Self | Self - Studio Guest Interview |
| The Talk | 2012–2019 | Self | Self |
| The Bachelor | 2019 | Self | Self - Audience Member |
| The E! People's Choice Awards | 2018 | Self | Self - Presenter |
| American Music Awards 2018 | 2018 | Self | Self - Presenter |
| Good Morning America | 2018 | Self | Self - Guest |
| The Late Late Show with James Corden | 2017–2018 | Self | Self |
| One Voice Somos Live: A Concert for Disaster Relief | 2017 | Self | Self |
| The Insider | 2017 | Self | Self |
| Harry | 2017 | Self | Self |
| The Chew | 2017 | Self | Self - Guest |
| Late Night with Seth Meyers | 2017 | Self | Self |
| Zoolander: Super Model | 2016 | Self | Self (voice) |
| Unity | 2015 | Self | Narrator (voice) |
| Sound Advice | 2015 | Self | Self |
| Talk Stoop | 2012–2014 | Self | Self |
| Big Morning Buzz Live | 2014 | Self | Self |
| The 68th Annual Tony Awards | 2014 | Self | Self - Presenter |
| The View | 2008–2014 | Self | Self - Guest |
| A Big Farewell to Our Upper East Siders Video | 2013 | Self | Self |
| Gossip Girl: Series Retrospective | 2012 | Self | Self |
| Gossip Girl: XO XO | 2012 | Self | Blair Waldorf |
| Live with Kelly and Mark | 2008–2012 | Self | Self - Guest |
| Gossip Girl: Gossip Girl Turns 100 Video | 2012 | Self | Self |
| 5 Years of Iconic Style Video | 2012 | Self | Self |
| Up Close with Carrie Keagan | 2011–2012 | Self | Self - Guest |
| Jimmy Kimmel Live! | 2012 | Self | Self - Guest |
| 2012 MTV Movie Awards | 2012 | Self | Self - Presenter |
| 'The Roommate': The Next Generation of Stars Video | 2011 | Self | Self |
| 'the Roommate': Dressing Dangerously Video | 2011 | Self | Self |
| Obsession: The Making of 'The Roommate' Video | 2011 | Self | Self |
| Gossip with the Girls | 2011 | Self | Self |
| Fashionista's Fantasy | 2011 | Self | Self |
| A Jet-Setters Dream | 2011 | Self | Self |
| Bisoux à Paris! Video | 2011 | Self | Self |
| Summer Sessions with Leighton Meester Video | 2011 | Self | Self |
| 2011 MTV Movie Awards | 2011 | Self | Self - Presenter |
| ES.TV HD | 2011 | Self | Self - Guest |
| Mark at the Movies | 2011 | Self | Self |
| Attack of the Show! | 2011 | Self | Self |
| Dropout | 2011 | Self | Self |
| Late Night with Jimmy Fallon | 2009–2011 | Self | Self - Guest |
| The 68th Annual Golden Globe Awards | 2011 | Self | Self - Presenter |
| Entertainers with Byron Allen | 2011 | Self | Self - Guest |
| The 37th Annual People's Choice Awards | 2011 | Self | Self |
| The Tonight Show with Jay Leno | 2011 | Self | Self - Guest |
| The 44th Annual CMA Awards | 2010 | Self | Self |
| Date Night: Disaster Dates Video | 2010 | Self | Self |
| Teen Choice Awards 2010 | 2010 | Self | Self - Winner |
| Luxury Unveiled TV Series | 2010 | Self | Self |
| The City | 2010 | Self | Self (uncredited) |
| Rachael Ray | 2010 | Self | Self - Guest |
| Top 20 Under 25 | 2010 | Self | Self |
| mtvU Woodie Awards 2009 TV Special | 2009 | Self | Self - Presenter |
| It's on with Alexa Chung | 2009 | Self | Self - Performer |
| The 61st Primetime Emmy Awards | 2009 | Self | Self - Presenter |
| 2009 MTV Video Music Awards | 2009 | Self | Self |
| Late Show with David Letterman | 2009 | Self | Self - Guest |
| Stylish Confessions: The Fashion of 'Gossip Girl' | 2009 | Self | Self |
| Gossip Girl: Faces Behind the Design | 2009 | Self | Self |
| Fifth Avenue Meets Gossip Girl | 2009 | Self | Self |
| The Teen Choice Awards 2009 | 2009 | Self | Self - Winner |
| 2009 MTV Movie Awards | 2009 | Self | Self - Presenter |
| The Ellen DeGeneres Show | 2009 | Self | Self - Guest |
| The Tyra Banks Show | 2008 | Self | Self - Guest |
| Kira Plastinina: In Her Own Words TV Special | 2008 | Self | Self |
| The Beginning, XOXO | 2008 | Self | Self |
| Gossip Girl Couture | 2008 | Self | Self |
| The Teen Choice Awards 2008 | 2008 | Self | Self - Accepting Award |
| Late Night with Conan O'Brien | 2008 | Self | Self - Guest |
| Total Request Live | 2007–2008 | Self | Self |
| Gossip Girl Revealed | 2008 | Self | Self |
| On Location with Remember the Daze | 2007 | Self | Self |
| The Spider Wrangler: The Spiders of Hangman's Curse | 2004 | Self | Self |
| Cartaz Cultural | 2003 | Self | Self |
| InformOverload | 2025 | Archive Footage | Self (archive footage) |
| ABC News Breakfast | 2025 | Archive Footage | Self - Actor |
| Entertainment Tonight | 2019–2025 | Archive Footage | Self (archive footage) |
| Hollywood Today Live | 2017 | Archive Footage | Self (archive footage) |
| Made in Hollywood | 2012 | Archive Footage | Self (archive footage) |
| The Roommate: Deleted & Alternate Scenes | 2011 | Archive Footage | Rebecca (archive footage) |