| Catherine Called Birdy | 2022 | Director | Director |
| Sharp Stick | 2022 | Director | Director |
| Who Will You Be? Video | 2020 | Director | Director |
| Industry | 2020 | Director | Director |
| Girls | 2012–2017 | Director | Director |
| 100 Years | 2017 | Director | Director |
| Max | 2016 | Director | director |
| Best Friends | 2013 | Director | Director |
| Tiny Furniture | 2010 | Director | Director |
| Creative Nonfiction | 2009 | Director | Director |
| Delusional Downtown Divas | 2009 | Director | Director |
| The Fountain | 2007 | Director | Director |
| Hooker on Campus | 2007 | Director | Director |
| Open the Door | 2007 | Director | Director |
| Tight Shots | 2007–2008 | Director | Director |
| Pressure | 2006 | Director | Director |
| Dealing | 2006 | Director | Director |
| Catherine Called Birdy | 2022 | Writer | screenplay by |
| Sharp Stick | 2022 | Writer | Writer |
| Generation | 2021 | Writer | written by |
| Camping | 2018 | Writer | created for American television by |
| Girls | 2012–2017 | Writer | created by |
| Cover Girl | 2014 | Writer | writer |
| Choose You | 2013 | Writer | Writer |
| Best Friends | 2013 | Writer | written by |
| Nobody Walks | 2012 | Writer | written by |
| Tiny Furniture | 2010 | Writer | written by |
| Creative Nonfiction | 2009 | Writer | written by |
| Delusional Downtown Divas | 2009 | Writer | writer |
| Tight Shots | 2007–2008 | Writer | Writer |
| Dealing | 2006 | Writer | written by |
| Treasure | 2024 | Actress | Ruth |
| Sharp Stick | 2022 | Actress | Heather |
| Music | 2021 | Actress | Administrator on Phone with Zu (voice) |
| The Stand In | 2020 | Actress | Lisa |
| Dirty Diana | 2020 | Actress | Lux (voice) |
| Honeydew | 2020 | Actress | Delilah |
| Once Upon a Time... in Hollywood | 2019 | Actress | 'Gypsy' |
| American Horror Story | 2017 | Actress | Valerie Solanas |
| Girls | 2012–2017 | Actress | Hannah Horvath |
| High Maintenance | 2016 | Actress | Lena Dunham |
| My Entire High School Sinking Into the Sea | 2016 | Actress | Mary (voice) |
| My Art | 2016 | Actress | Meryl |
| Adventure Time | 2014–2016 | Actress | Betty Grof (voice) |
| Don't Think Twice | 2016 | Actress | Lena Dunham |
| The Simpsons | 2015 | Actress | Candace |
| Sky | 2015 | Actress | Billie |
| Taylor Swift: Bad Blood | 2015 | Actress | Lucky Fiori |
| Scandal | 2015 | Actress | Susanne Thomas |
| 7 Days in Hell | 2015 | Actress | Lanny Denver |
| Happy Christmas | 2014 | Actress | Carson |
| This Is 40 | 2012 | Actress | Cat |
| Obama for America: Lena's First Time Video | 2012 | Actress | |
| Supporting Characters | 2012 | Actress | Alexa |
| Mildred Pierce | 2011 | Actress | Nurse 1 |
| The Innkeepers | 2011 | Actress | Barista |
| Tiny Furniture | 2010 | Actress | Aura |
| Gabi on the Roof in July | 2010 | Actress | Colby |
| Family Tree | 2009 | Actress | Lena |
| The Viewer | 2009 | Actress | The Voice |
| The House of the Devil | 2009 | Actress | 911 Operator (voice) |
| Creative Nonfiction | 2009 | Actress | Ella |
| Delusional Downtown Divas | 2009 | Actress | Oona |
| Una & Jacques | 2007 | Actress | |
| Tight Shots | 2007–2008 | Actress | |
| Dealing | 2006 | Actress | Georgia |
| Treasure | 2024 | Producer | producer |
| Orgasm Inc: The Story of OneTaste | 2022 | Producer | executive producer |
| Catherine Called Birdy | 2022 | Producer | producer (produced by) |
| Sharp Stick | 2022 | Producer | producer |
| Generation | 2021 | Producer | executive producer |
| Camping | 2018 | Producer | executive producer |
| Lenny | 2018 | Producer | executive producer |
| Tokyo Project | 2017 | Producer | executive producer |
| Girls | 2012–2017 | Producer | executive producer |
| 100 Years | 2017 | Producer | producer |
| Max | 2016 | Producer | executive producer |
| Suited | 2016 | Producer | producer |
| It's Me, Hilary: The Man Who Drew Eloise | 2015 | Producer | executive producer |
| Delusional Downtown Divas | 2009 | Producer | producer |
| Creative Nonfiction | 2009 | Editor | Editor |
| Tight Shots | 2007–2008 | Editor | Editor |
| Britney vs Spears | 2021 | Thanks | special thanks |
| Beastie Boys Story | 2020 | Thanks | special thanks |
| Kajillionaire | 2020 | Thanks | special thanks |
| Memory Xperiment: Kathy Acker | 2019 | Thanks | thanks |
| Mommy Dead and Dearest | 2017 | Thanks | special thanks |
| Amy Schumer: The Leather Special | 2017 | Thanks | special thanks |
| Neighbors 2: Sorority Rising | 2016 | Thanks | special thanks |
| Don't Think Twice | 2016 | Thanks | thanks |
| Thought Crimes: The Case of the Cannibal Cop | 2015 | Thanks | special thanks |
| The One I Love | 2014 | Thanks | thank you |
| Dom Hemingway | 2013 | Thanks | special thanks |
| Bottled Short | 2012 | Thanks | special thanks |
| Sleepwalk with Me | 2012 | Thanks | the filmmakers wish to thank |
| The House of the Devil | 2009 | Thanks | special thanks |
| Girls | 2013–2017 | Soundtrack | performer: "Fast Car" |
| The Tonight Show Starring Jimmy Fallon | 2015 | Soundtrack | Soundtrack ("Outside", "Fat Bottomed Girls") |
| Saturday Night Live | 2014 | Soundtrack | performer: "O-o-h Child" (uncredited) |
| Gavin & Stacey: A Fond Farewell | 2025 | Self | Self |
| Morgenmagazin | 2024 | Self | Self |
| Made in Hollywood | 2022–2024 | Self | Self |
| Finding Your Roots with Henry Louis Gates, Jr. | 2024 | Self | Self |
| Lights, Camera, Take Action! A Benefit for the Motion Picture & Television Fund TV Special | 2023 | Self | Self |
| Judy Blume Forever | 2023 | Self | Self |
| UnWrapped Podcast Series | 2023 | Self | Self - Guest |
| In Creative Company | 2022 | Self | Self |
| Kermode & Mayo's Take | 2022 | Self | Self - Guest |
| The Kelly Clarkson Show | 2022 | Self | Self - Guest |
| Unqualified | 2022 | Self | Self - Guest |
| The Late Late Show with James Corden | 2015–2022 | Self | Self - Guest |
| People Entertainment Weekly: Toronto 2022 TV Mini Series | 2022 | Self | Self |
| Variety Studio | 2015–2022 | Self | Self |
| The Drew Barrymore Show | 2021–2022 | Self | Self - Guest |
| Late Night with Seth Meyers Podcast | 2022 | Self | Self - Guest |
| Late Night with Seth Meyers | 2014–2022 | Self | Self - Guest |
| The Hollywood Reporter: Studio at Toronto TV Mini Series | 2022 | Self | Self |
| Talk Easy with Sam Fragoso | 2022 | Self | Self |
| Women of the Hour | 2015–2021 | Self | Self - Host |
| Good Friend with Jamie Lee Curtis Podcast Series | 2021 | Self | Self - Guest |
| A Little Late with Lilly Singh | 2021 | Self | Self |
| AFI Movie Club | 2020 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2018–2020 | Self | Self - Guest |
| Visible: Out on Television | 2020 | Self | Self (writer - actor) |
| The Jonathan Ross Show | 2019 | Self | Self - Guest |
| Talk Art | 2019 | Self | Self |
| Hollywood Insider | 2019 | Self | Self |
| Life is Short with Justin Long | 2019 | Self | Self - Guest |
| The C-Word Podcast Series | 2019 | Self | Self - Host |
| Armchair Expert with Dax Shepard | 2018 | Self | Self |
| Today | 2015–2018 | Self | Self - Guest |
| Jimmy Kimmel Live! | 2014–2018 | Self | Self - Guest |
| This Changes Everything | 2018 | Self | Self |
| RuPaul's Drag Race: Untucked! | 2018 | Self | Self - Guest |
| RuPaul's Drag Race | 2018 | Self | Self - Guest Judge |
| Half the Picture | 2018 | Self | Self |
| Travel Man: 48 Hours in... | 2017 | Self | Self |
| The Ellen DeGeneres Show | 2014–2017 | Self | Self - Guest |
| Ctrl Alt Delete Podcast Series | 2017 | Self | Self |
| God kveld Norge | 2017 | Self | Self - Interviewee |
| WTF with Marc Maron | 2014–2017 | Self | Self - Guest |
| Allison's Edge Video | 2017 | Self | Self |
| The View | 2014–2017 | Self | Self - Guest |
| The Tonight Show Starring Jimmy Fallon | 2014–2017 | Self | Self - Guest |
| Inside the Actors Studio | 2017 | Self | Self - Guest |
| 73 Questions | 2017 | Self | Self |
| Red Nose Day | 2016 | Self | Self |
| Inside Amy Schumer | 2016 | Self | Self |
| The Chris Gethard Show | 2016 | Self | Self - Guest |
| Celebrity Style Story | 2016 | Self | Self |
| Taylor Swift: The 1989 World Tour Live | 2015 | Self | Self - Special Guest |
| Harper's Bazaar: YouTube Channel TV Series | 2015 | Self | Self |
| Everything Is Copy | 2015 | Self | Self |
| Close Up with the Hollywood Reporter | 2015 | Self | Self |
| Thank You and Sorry | 2015 | Self | |
| Entertainment Tonight | 2014–2015 | Self | Self |
| Variety: YouTube Channel TV Series | 2015 | Self | Self |
| Harmontown | 2015 | Self | Self - Audience |
| Late Show with David Letterman | 2013–2015 | Self | Self - Guest |
| Follow Me TV Series | 2015 | Self | Self |
| It's Me, Hilary: The Man Who Drew Eloise | 2015 | Self | Self |
| The Late Late Show with Craig Ferguson | 2010–2015 | Self | Self - Guest |
| E! Live from the Red Carpet | 2014–2015 | Self | Self |
| 72nd Golden Globe Awards | 2015 | Self | Self - Nominee |
| Live with Kelly and Mark | 2014–2015 | Self | Self - Guest |
| Skavlan | 2009–2021 | Self | Self - Guest |
| The Graham Norton Show | 2014 | Self | Self - Guest |
| Makers: Women Who Make America | 2014 | Self | Self |
| MAKERS TV Series | 2014 | Self | Self |
| The Daily Show | 2013–2014 | Self | Self - Guest |
| Side by Side Extra: Volume One | 2014 | Self | Self |
| Good Morning America | 2014 | Self | Self - Guest |
| The 66th Primetime Emmy Awards | 2014 | Self | Self - Nominee |
| Howard Stern Birthday Bash | 2014 | Self | Self |
| This Is Comedy | 2014 | Self | Self |
| Billy on the Street | 2014 | Self | Self - Guest |
| Saturday Night Live | 2014 | Self | Self - Host |
| Cover Girl | 2014 | Self | Self |
| 2014 Golden Globe Arrivals Special | 2014 | Self | Self - Interviewee |
| 71st Golden Globe Awards | 2014 | Self | Self - Nominee (uncredited) |
| The 65th Primetime Emmy Awards | 2013 | Self | Self - Nominee |
| CBS News Sunday Morning with Jane Pauley | 2013 | Self | Self - Guest |
| Girls: Guys on Girls Featurette TV Short | 2013 | Self | Self |
| Here's the Thing with Alec Baldwin Podcast Series | 2013 | Self | Self - Guest (voice) |
| Revealed | 2013 | Self | Self |
| 70th Golden Globe Awards | 2013 | Self | Self - Winner |
| Charlie Rose | 2013 | Self | Self - Guest |
| Iconoclasts | 2012 | Self | Self |
| The 64th Primetime Emmy Awards | 2012 | Self | Self - Nominee |
| Side by Side Extra Short | 2012 | Self | Self |
| Late Night with Jimmy Fallon | 2012 | Self | Self - Guest |
| The Colbert Report | 2012 | Self | Self - Guest |
| Chelsea Lately | 2012 | Self | Self - Guest |
| Conan | 2012 | Self | Self - Guest |
| Girls: About Girls | 2012 | Self | Hannah Horvath |
| Girls: Invitation to the Set Video | 2012 | Self | Hannah Horvath |
| Side by Side | 2012 | Self | Self |
| MSN Exclusives | 2012 | Self | Self (2013) |
| PressPausePlay | 2011 | Self | Self |
| The 2011 Independent Spirit Awards | 2011 | Self | Self - Winner |
| Last Call with Carson Daly | 2010 | Self | Self - Guest |
| Cecil Says | 2024 | Archive Footage | Self (archive footage) |
| WatchMojo | 2023 | Archive Footage | Self (archive footage) |
| Entertainment Tonight | 2014–2019 | Archive Footage | Self |
| Lena Dunham Says Something Stupid... As Always Video | 2017 | Archive Footage | Self (archive footage) |
| Celebrity Page | 2015–2017 | Archive Footage | Self (archive footage) |
| The History of Comedy | 2017 | Archive Footage | Hannah Horvath (archive footage) |
| From the Start! TV Series | 2016 | Archive Footage | Lucky Fiori (archive footage) |
| Extra | 2015 | Archive Footage | Self (archive footage) |
| Media Buzz | 2015 | Archive Footage | Self (archive footage) |
| Inside Edition | 2014–2015 | Archive Footage | Self (archive footage) |
| The Insider | 2014 | Archive Footage | Self (archive footage) |
| Showrunners: The Art of Running a TV Show | 2014 | Archive Footage | Self - Girls, Creator (archive footage) |