| Little Simz feat. Cleo Sol: Woman | 2021 | Director | Director |
| Coldplay Feat. Little Simz x Burna Boy x Elyanna & TINI: We Pray (Elyanna Version) Music Video | 2024 | Actress | Little Simz |
| Coldplay Feat. Little Simz x Burna Boy x Elyanna & TINI: We Pray (TINI Version) Music Video | 2024 | Actress | Little Simz |
| Coldplay: We Pray (Little Simz Version) Music Video | 2024 | Actress | Little Simz |
| RM Feat. Little Simz: Domodachi | 2024 | Actress | Little Simz (voice) |
| Top Boy | 2013–2023 | Actress | Shelley |
| Little Simz: Gorilla | 2023 | Actress | |
| The Power | 2023 | Actress | Adunola (as Simbi Ajikawo) |
| I Love You I Hate You | 2021 | Actress | Sage |
| Venom: Let There Be Carnage | 2021 | Actress | Little Simz |
| Little Simz feat. Obongjayar: Point and Kill | 2021 | Actress | |
| Little Simz: Introvert | 2021 | Actress | Little Simz |
| Afrofuturism | 2017 | Actress | Narrator |
| Little Simz: Stillness in Wonderland Short | 2016 | Actress | |
| Kehlani feat. Little Simz: Table Music Video | 2016 | Actress | Little Simz |
| Lena feat. Kat Vinter & Little Simz: Catapult | 2015 | Actress | Little Simz |
| Youngers | 2013 | Actress | Meleka (as Lil Simz) |
| Ill Manors | 2012 | Actress | Youth Suspect at the Railway Station (as Lil Simz) |
| Spirit Warriors | 2010 | Actress | Vicky (as Lil Simz) |
| I Love You I Hate You | 2021 | Producer | executive producer |
| Little Simz feat. Cleo Sol: Woman | 2021 | Composer | Composer |
| Little Simz: Introvert | 2021 | Composer | Composer |
| Kehlani feat. Little Simz: Table Music Video | 2016 | Composer | Composer |
| Little Simz feat. Cleo Sol: Woman | 2021 | Music Department | musician: rap vocals |
| Little Simz: Introvert | 2021 | Music Department | musician: rap vocals |
| Dope Thief | 2025 | Soundtrack | performer: "Point and Kill" |
| Coldplay: A Film for the Future Short | 2025 | Soundtrack | performer: "WE PRAY" |
| High Potential | 2024 | Soundtrack | performer: "Point and Kill" |
| Saturday Night Live | 2024 | Soundtrack | writer: "We Pray" (uncredited) |
| Dumb Money | 2023 | Soundtrack | performer: "Boss" |
| Dead Ringers | 2023 | Soundtrack | performer: "Might Bang, Might Not" |
| Atlanta | 2022 | Soundtrack | performer: "Point and Kill" |
| The Bubble | 2022 | Soundtrack | performer: "Might Bang, Might Not" |
| The Late Late Show with James Corden | 2021 | Soundtrack | performer: "I Love You, I Hate You" |
| Jimmy Kimmel Live! | 2021 | Soundtrack | performer: "Speed" |
| Dickinson | 2021 | Soundtrack | performer: "Introvert" |
| Ear for Eye | 2021 | Soundtrack | performer: "Offence" |
| Venom: Let There Be Carnage | 2021 | Soundtrack | performer: "Venom", "Venom Remix" |
| Tonight with Target | 2021 | Soundtrack | performer: "I Love You, I Hate You" |
| The Tonight Show Starring Jimmy Fallon | 2014 | Soundtrack | performer: "Woman" |
| Generation | 2021 | Soundtrack | performer: "might bang, might not" |
| Little Simz feat. Cleo Sol: Woman | 2021 | Soundtrack | performer: "Woman" |
| Little Simz: Introvert | 2021 | Soundtrack | performer: "Introvert" |
| Body Brokers | 2021 | Soundtrack | performer: "Boss" |
| Malcolm & Marie | 2021 | Soundtrack | performer: "Selfish" |
| We Are Who We Are | 2020 | Soundtrack | performer: "Persons" |
| The Duchess | 2020 | Soundtrack | writer: "Proud of Me" (uncredited) |
| NBA 2K21 | 2020 | Soundtrack | performer: "Venom" |
| I May Destroy You | 2020 | Soundtrack | performer: "Out of Sight (yhyh)" |
| Gangs of London | 2020 | Soundtrack | performer: "Offence" |
| On My Block | 2020 | Soundtrack | performer: "Offence" |
| Dare Me | 2020 | Soundtrack | performer: "BOSS" |
| Victoria Derbyshire | 2020 | Soundtrack | performer: "Offence" (uncredited) |
| Servant | 2019 | Soundtrack | performer: "Sherbet Sunset" |
| Rocks | 2019 | Soundtrack | performer: "Hold My Mule" |
| VS. | 2018 | Soundtrack | performer: "Backseat" |
| Insecure | 2018 | Soundtrack | performer: "BOSS" |
| Best Before TV Series | 2015 | Soundtrack | performer: "Don't Forget" |
| Leave to Remain | 2013 | Soundtrack | performer: "Leave It As That" |
| Chicken Shop Date | 2025 | Self | Self |
| Match of the Day Live: UEFA Euro 2024 TV Mini Series | 2024 | Self | Self |
| Camden | 2024 | Self | Self |
| ELLE: YouTube Channel | 2024 | Self | Self |
| Miu Miu: Fall/Winter 2024 Show Video | 2024 | Self | Self - Model |
| The Late Show with Stephen Colbert | 2023 | Self | Self - Musical Guest |
| 2023 EE BAFTA Film Awards | 2023 | Self | Self - Performer |
| The Jonathan Ross Show | 2022 | Self | Self - Musical Guest |
| BandLab NME Awards 2022 TV Special | 2022 | Self | |
| The Brit Awards 2022 | 2022 | Self | Self |
| How We Make TV Mini Series | 2021 | Self | Self |
| The Late Late Show with James Corden | 2021 | Self | Self - Musical Guest |
| Jimmy Kimmel Live! | 2021 | Self | Self - Musical Guest |
| Skavlan | 2021 | Self | Self - Guest and Performer |
| Tonight with Target | 2021 | Self | Self - Guest |
| The Tonight Show Starring Jimmy Fallon | 2014 | Self | Self - Musical Guest |
| Little Simz feat. Cleo Sol: Woman | 2021 | Self | Self |
| Gorillaz: Reject False Icons | 2019 | Self | Self |
| Sunday Brunch | 2019 | Self | Self - Guest |
| The Big Narstie Show | 2019 | Self | Self |
| Berlin Live | 2019 | Self | Self |
| Same But Different Short | 2016 | Self | Self - Host |
| Launched at Red Bull Studios TV Series | 2016 | Self | Self |
| Tavis Smiley | 2016 | Self | Self |
| Introducing TV Series | 2014 | Self | Self |
| Spirit Warriors: Backstage TV Movie | 2010 | Self | Self (as Lil Simz) |
| First Ladies of Hip-Hop | 2023 | Archive Footage | Self (archive footage) |
| Glastonbury 2022 | 2022 | Archive Footage | Self (archive footage) |
| Best Before TV Series | 2015 | Archive Sound | Self (archive footage) |