| In My Genes | 2009 | Director | Director |
| The Wild Robot | 2024 | Actress | Roz |
| A Quiet Place: Day One | 2024 | Actress | Samira |
| Brent Faiyaz: WY@ | 2024 | Actress | |
| Big Mouth | 2023 | Actress | Asha (voice) |
| Black Panther: Wakanda Forever | 2022 | Actress | Nakia |
| Human Resources | 2022 | Actress | Asha (voice) |
| The 355 | 2022 | Actress | Khadijah Adiyeme |
| Who Are You, Charlie Brown? | 2021 | Actress | Narrator (voice) |
| Super Sema | 2021 | Actress | Sema (voice) |
| Beyoncé, Blue Ivy, Saint Jhn, WizKid: Brown Skin Girl | 2020 | Actress | Lupita Nyong'o |
| Black Is King | 2020 | Actress | Lupita Nyong'o |
| James and the Giant Peach with Taika and Friends | 2020 | Actress | James |
| Star Wars: Episode IX - The Rise of Skywalker | 2019 | Actress | Maz Kanata |
| Us | 2019 | Actress | Adelaide Wilson |
| Little Monsters | 2019 | Actress | Miss Caroline |
| Star Wars: Forces of Destiny | 2017–2018 | Actress | Maz Kanata (voice) |
| Jack: Part One | 2018 | Actress | The Giant |
| Black Panther | 2018 | Actress | Nakia |
| Star Wars: Episode VIII - The Last Jedi | 2017 | Actress | Maz Kanata |
| Jay-Z: MaNyfaCedGod | 2017 | Actress | Woman |
| Queen of Katwe | 2016 | Actress | Nakku Harriet |
| Lego Star Wars: The Force Awakens | 2016 | Actress | Maz Kanata (voice) |
| The Jungle Book | 2016 | Actress | Raksha (voice) |
| Star Wars: Episode VII - The Force Awakens | 2015 | Actress | Maz Kanata |
| Nature Is Speaking | 2014 | Actress | Flower (voice) |
| Non-Stop | 2014 | Actress | Gwen |
| 12 Years a Slave | 2013 | Actress | Patsey |
| Shuga | 2009–2012 | Actress | Ayira |
| Star Tours: The Adventures Continue | 2011 | Actress | Maz Kanata |
| The Roadside Short | 2009 | Actress | |
| East River | 2008 | Actress | F |
| Roho | 2006 | Actress | Laila |
| Goodbye Julia | 2023 | Producer | executive producer |
| Americanah | 2021 | Producer | producer |
| Super Sema | 2021 | Producer | executive producer |
| The Roadside Short | 2009 | Producer | producer |
| In My Genes | 2009 | Producer | executive producer |
| In My Genes | 2009 | Editor | Editor |
| Where God Left His Shoes | 2007 | Art Department | art intern |
| In My Genes | 2009 | Sound Department | sound editor |
| The Namesake | 2006 | Editorial Department | post-production intern |
| MPower | 2023 | Additional Crew | archival sources |
| In My Genes | 2009 | Additional Crew | publicist |
| The Constant Gardener | 2005 | Additional Crew | production runner: Kenya (as Lupita Nyongo) |
| Little Monsters | 2019 | Soundtrack | performer: "Shake it Off", "Little Bo-Peep" (uncredited), "Old MacDonald Had A Farm" (uncredited), "I Don't Want To Live On The Moon", "Lady Magdalene", "The Wheel on the Bus" (uncredited), "If You're Happy and You Know It" (uncredited), "Five Little Ducks" (uncredited) |
| The Tonight Show Starring Jimmy Fallon | 2015 | Soundtrack | performer: "Theme from 'Star Wars'", "The Throne Room" (uncredited) |
| The Oscars | 2025 | Self | Audience Member |
| Page Six: YouTube Channel TV Series | 2025 | Self | Self - Guest |
| 2025 EE BAFTA Film Awards | 2025 | Self | Self - Presenter |
| The 30th Annual Critics' Choice Awards | 2025 | Self | Self - Presenter |
| Studio 5 TV Series | 2024 | Self | Self - Actress |
| The Magic Behind the Movie Video | 2024 | Self | Self |
| Die besten Horrorfilme aller Zeiten TV Special | 2024 | Self | Self |
| What Now? with Trevor Noah | 2024 | Self | Self - Guest |
| Harper's Bazaar UK TV Series | 2019–2024 | Self | Self - Guest |
| Morgenmagazin | 2024 | Self | Self |
| Little Gold Men by Vanity Fair Podcast Series | 2024 | Self | Self - Guest |
| Días de cine | 2024 | Self | Self - Interviewee |
| Entertainment Tonight | 2014–2024 | Self | Self |
| Sherri | 2024 | Self | Self |
| SiriusXM: YouTube Channel TV Series | 2024 | Self | Self |
| TheWrap: YouTube Channel TV Series | 2024 | Self | Self |
| IMDb on the Scene | 2024 | Self | Self - Guest |
| Jake's Takes | 2024 | Self | Self - Guest |
| Rama's Screen TV Series | 2024 | Self | Self - Guest |
| The Tonight Show Starring Jimmy Fallon | 2015–2024 | Self | Self - Guest |
| Deadline Studio | 2024 | Self | Self - Guest |
| Today | 2016–2024 | Self | Self - Guest |
| IMDb Originals | 2024 | Self | Self |
| Letterboxd TV Series | 2024 | Self | Self |
| BuzzFeed Celeb | 2024 | Self | Self |
| IMDb Interviews | 2022–2024 | Self | Self - Guest |
| LADbible Entertainment TV Series | 2024 | Self | Self |
| Hot Ones | 2024 | Self | Self - Guest |
| The Kelly Clarkson Show | 2024 | Self | Self - Guest |
| CBS Mornings | 2024 | Self | Self |
| Late Night with Seth Meyers | 2016–2024 | Self | Self |
| Jimmy Kimmel Live! | 2014–2024 | Self | Self |
| C à vous | 2024 | Self | Self |
| The Oscars Red Carpet Show | 2024 | Self | Self |
| The Oscars | 2024 | Self | Self - Presenter |
| Berlinale TV Series | 2024 | Self | Self |
| Disney 100: A Century of Dreams - A Special Edition of 20/20 | 2023 | Self | Self |
| Dish Nation | 2019–2023 | Self | Self |
| The 76th Annual Tony Awards | 2023 | Self | Self - Presenter |
| MPower | 2023 | Self | Self - Nakia |
| Marvel Studios: Assembled | 2023 | Self | Self - Nakia |
| Fantastic | 2022 | Self | Self (as Lupita Nyongo) |
| UFC 281: Adesanya vs. Pereira | 2022 | Self | Self - Audience Member |
| Jornal das 8 | 2022 | Self | Self |
| Newsround | 2022 | Self | Self |
| Burning Questions | 2022 | Self | Self |
| This Morning | 2022 | Self | Self |
| 20/20 | 2022 | Self | Self |
| Live with Kelly and Mark | 2014–2022 | Self | Self |
| Good Morning America | 2015–2022 | Self | Self - Guest |
| NBC Sunday Night Football | 2022 | Self | Self |
| The 355: Tilbury Docks Video | 2022 | Self | Self - Actress |
| The 355: Interviews with the Cast and Crew Video | 2022 | Self | Self - Actress |
| The Oscars | 2022 | Self | Self - Presenter |
| The 355: Reconstructing Marrakesh Video | 2022 | Self | Self - Actress |
| The 2021 Rock & Roll Hall of Fame Induction Ceremony | 2021 | Self | Self |
| In América: A Lexicon of Fashion | 2021 | Self | Self |
| Serengeti | 2019–2021 | Self | Narrator (voice) |
| The Ellen DeGeneres Show | 2014–2021 | Self | Self |
| Hollywood Insider | 2020–2021 | Self | Self |
| The Late Show with Stephen Colbert | 2015–2021 | Self | Self - Guest |
| Premios Goya 35 edición | 2021 | Self | Self - Greeter |
| Bookmarks | 2020 | Self | Self - Storyteller |
| Martha Knows Best | 2020 | Self | Self |
| One World: Together at Home | 2020 | Self | Self |
| Worlds Beyond Earth | 2020 | Self | Narrator |
| The 26th Annual Screen Actors Guild Awards | 2020 | Self | Self - Nominee & Presenter |
| Close Up with the Hollywood Reporter | 2020 | Self | Self |
| The 25th Annual Critics' Choice Awards | 2020 | Self | Self - Presenter & Nominee |
| Inside the Actors Studio | 2019 | Self | Self - Guest |
| Celebrity Page | 2019 | Self | Self |
| The View | 2013–2019 | Self | Self |
| The Daily Show | 2015–2019 | Self | Self |
| The British Academy Britannia Awards | 2019 | Self | Self - Presenter |
| Warrior Women with Lupita Nyong'o | 2019 | Self | |
| Newsnight | 2019 | Self | Self - Actress |
| Complex x Fuse | 2019 | Self | Self |
| 50th NAACP Image Awards | 2019 | Self | Self - Presenter |
| Sunday Today with Willie Geist | 2019 | Self | Self - Guest |
| Desus & Mero | 2019 | Self | Self |
| IMDb's Cast Connections | 2019 | Self | Self - Guest |
| WGN Morning News | 2019 | Self | Self |
| Extra | 2014–2019 | Self | Self |
| Entertainment Tonight Canada | 2018–2019 | Self | Self |
| 2 Dope Queens | 2019 | Self | Self |
| Variety Studio | 2016–2019 | Self | Self |
| The 25th Annual Screen Actors Guild Awards | 2019 | Self | Self |
| Black Panther Power | 2019 | Self | Self |
| Variety Studio: Actors on Actors | 2019 | Self | Self |
| E! Live from the Red Carpet | 2014–2019 | Self | Self |
| 2019 Golden Globe Awards | 2019 | Self | Self - Presenter |
| Black Panther: The Warriors Within | 2018 | Self | Self |
| Black Panther: The Hidden Kingdom Revealed | 2018 | Self | Self |
| My Africa | 2018 | Self | Self - Narrator |
| The Dream Still Lives | 2018 | Self | Self |
| The Oscars | 2018 | Self | Self - Presenter |
| Essence 11th Annual Black Women in Hollywood Awards | 2018 | Self | Self |
| The EE British Academy Film Awards | 2018 | Self | Self - Presenter |
| Made in Hollywood | 2013–2018 | Self | Self |
| Celebrities Answer the Web's Most Searched Questions | 2018 | Self | Self |
| Last Week | 2018 | Self | Self |
| Good Morning Britain | 2018 | Self | Self - Guest |
| The IMDb Show | 2018 | Self | Self - Guest |
| 24th Annual Screen Actors Guild Awards | 2018 | Self | Self - Presenter |
| Movie Surfers | 2018 | Self | Self |
| The Oh My Disney Show TV Series | 2017 | Self | Self |
| Live from the Red Carpet of Star Wars: The Last Jedi | 2017 | Self | Self |
| Finding Your Roots with Henry Louis Gates, Jr. | 2017 | Self | Self |
| 2017 Global Citizen TV Special | 2017 | Self | Self |
| Hand in Hand: A Benefit for Hurricane Relief | 2017 | Self | Self |
| ScreenSlam | 2015–2017 | Self | Self |
| Billy on the Street | 2016 | Self | Self |
| Lip Sync Battle | 2016 | Self | Self - Competitor |
| Lip Sync Battle Preshow | 2016 | Self | Self |
| Steve Harvey | 2016 | Self | Self |
| IMDb First Credit | 2016 | Self | Self |
| Watch What Happens Live with Andy Cohen | 2016 | Self | Self - Guest |
| August 28th | 2016 | Self | Self |
| The 70th Annual Tony Awards | 2016 | Self | Self - Nominee |
| The Tony Beat TV Series | 2016 | Self | Self |
| Celebrity Style Story | 2016 | Self | Self |
| 2016 MTV Movie Awards | 2016 | Self | Self - Nominee |
| Theater Talk | 2016 | Self | Self - Guest |
| The Force Awakens: Force for Change | 2016 | Self | Self |
| ILM: The Visual Magic of 'The Force Awakens' | 2016 | Self | Self |
| Secrets of the Force Awakens: A Cinematic Journey | 2016 | Self | Self |
| Essence Ninth Annual Black Women in Hollywood | 2016 | Self | Self |
| Disneyland 60th Anniversary TV Special | 2016 | Self | Self |
| Star Wars: Greatest Moments | 2015 | Self | Self |
| Oprah Goes to Broadway: The Color Purple | 2015 | Self | Self |
| Conan | 2014–2015 | Self | Self - Guest |
| Unfiltered with Renee Young | 2015 | Self | Self |
| Nunca es tarde | 2015 | Self | Self - Interviewee |
| The Insider | 2013–2015 | Self | Self |
| Star Wars: The Force Awakens World Premiere Red Carpet | 2015 | Self | Self |
| Clevver News | 2015 | Self | Self |
| Rotten Tomatoes | 2015 | Self | Self |
| Associated Press: YouTube Channel | 2015 | Self | Self |
| 73 Questions | 2015 | Self | Self |
| Cannes Film Festival | 2015 | Self | Self - Audience Member |
| The Oscars | 2015 | Self | Self - Presenter |
| The 21st Annual Screen Actors Guild Awards | 2015 | Self | Self - Presenter |
| 72nd Golden Globe Awards | 2015 | Self | Self - Presenter |
| Sesame Street | 2014 | Self | Self |
| Kid President: Declaration of Awesome | 2014 | Self | Self - Guest |
| 2014 MTV Movie Awards | 2014 | Self | Self - Cameo #13 |
| 12 Years a Slave: A Historical Portrait | 2014 | Self | Self |
| Inside Edition | 2014 | Self | Self |
| La noche de los Oscar TV Series | 2014 | Self | Self |
| The Oscars | 2014 | Self | Self - Winner |
| The 2014 Film Independent Spirit Awards | 2014 | Self | Self - Winner |
| 45th NAACP Image Awards | 2014 | Self | Self |
| Late Show with David Letterman | 2014 | Self | Self - Guest |
| The EE British Academy Film Awards | 2014 | Self | Self - Nominee |
| Late Night with Jimmy Fallon | 2014 | Self | Self - Guest |
| The Queen Latifah Show | 2014 | Self | Self - Guest |
| Rencontres de cinéma | 2014 | Self | Self |
| 20th Annual Screen Actors Guild Awards | 2014 | Self | Self - Presenter & Winner |
| 19th Annual Critics' Choice Movie Awards | 2014 | Self | Self - Winner |
| Tavis Smiley | 2014 | Self | Self - Guest |
| 71st Golden Globe Awards | 2014 | Self | Self - Nominee (uncredited) |
| The Hollywood Reporter Roundtables | 2013 | Self | Self |
| The Late Late Show with Craig Ferguson | 2013 | Self | Self - Guest |
| TV One on One | 2013 | Self | Self - Guest |
| The Reel Story: 12 Years a Slave | 2013 | Self | Self |
| Entertainment Tonight | 2014–2024 | Archive Footage | Self (archive footage) |
| Morgenmagazin | 2024 | Archive Footage | Self (archive footage) |
| The Unbridled Series | 2023 | Archive Footage | Self (archive footage) |
| Nerdrotic | 2022–2023 | Archive Footage | Self (archive footage) |
| Dish Nation | 2022–2023 | Archive Footage | Self (archive footage) |
| Tucker Carlson Originals | 2023 | Archive Footage | Self (archive footage) |
| Marvel Studios: Legends | 2022 | Archive Footage | Nakia (archive footage, uncredited) |
| Gutfeld! | 2022 | Archive Footage | Self (archive footage) |
| The 355: Packing a Punch Video | 2022 | Archive Footage | Self - Actress (archive footage) |
| The Critical Drinker | 2022 | Archive Footage | Self (archive footage) |
| Moments Within Moments | 2021 | Archive Footage | Self (archive footage) |
| Finding Your Roots with Henry Louis Gates, Jr. | 2020 | Archive Footage | Self - Guest (archive footage) |
| Celebrity Page | 2017–2020 | Archive Footage | Self (archive footage) |
| Hollywood's Stories | 2019 | Archive Footage | Self (archive footage) |
| The Movies | 2019 | Archive Footage | Patsey (archive footage) |
| Africa Rising TV Movie | 2019 | Archive Footage | Self (archive footage) |
| Extra | 2018 | Archive Footage | Self (archive footage) |
| Inside Edition | 2015 | Archive Footage | Self (archive footage) |
| The Insider | 2015 | Archive Footage | Self (archive footage) |
| Screenwipe | 2014 | Archive Footage | Self (archive footage) |
| The Tonight Show Starring Jimmy Fallon | 2014 | Archive Footage | Self (archive footage, uncredited) |
| Star Wars: Rebels | 2018 | Archive Sound | Maz Kanata (archive footage, uncredited) |