| Rich Flu | 2024 | Actress | Laura Palmer |
| A Gentleman in Moscow | 2024 | Actress | Anna Urbanova |
| Scott Pilgrim Takes Off | 2023 | Actress | Ramona Flowers (voice) |
| Ahsoka | 2023 | Actress | Hera Syndulla |
| Kate | 2021 | Actress | Kate |
| Birds of Prey and the Fantabulous Emancipation of One Harley Quinn | 2020 | Actress | Helena Bertinelli |
| Gemini Man | 2019 | Actress | Danny Zakarewski |
| Love, Death & Robots | 2019 | Actress | Gail |
| The Parts You Lose | 2019 | Actress | Gail |
| All About Nina | 2018 | Actress | Nina Geld |
| Danger & Eggs | 2017 | Actress | Trix Blixon |
| Fargo | 2017 | Actress | Nikki Swango |
| Mercy Street | 2016–2017 | Actress | Mary Phinney |
| So It Goes | 2016 | Actress | Samantha |
| Portugal. The Man: Noise Pollution (Version A, Vocal Up Mix 1.3) | 2016 | Actress | Mary Elizabeth Winstead |
| BrainDead | 2016 | Actress | Laurel Healy |
| Brad Neely's Harg Nallin' Sclopio Peepio | 2016 | Actress | Guest Star (voice) |
| 10 Cloverfield Lane | 2016 | Actress | Michelle |
| The Hollars | 2016 | Actress | Gwen |
| Swiss Army Man | 2016 | Actress | Sarah |
| Exposed | 2015 | Actress | Anna Loach |
| The Returned | 2015 | Actress | Rowan Blackshaw |
| Got a Girl: Did We Live Too Fast | 2014 | Actress | Wife |
| Kill the Messenger | 2014 | Actress | Anna Simons |
| Alex of Venice | 2014 | Actress | Alex |
| Faults | 2014 | Actress | Claire |
| A Good Day to Die Hard | 2013 | Actress | Lucy |
| A.C.O.D. | 2013 | Actress | Lauren |
| The Spectacular Now | 2013 | Actress | Holly |
| Casque | 2012 | Actress | Girl |
| A Glimpse Inside the Mind of Charles Swan III | 2012 | Actress | Kate |
| The Beauty Inside | 2012 | Actress | Leah |
| Abraham Lincoln: Vampire Hunter | 2012 | Actress | Mary Todd Lincoln |
| Funny Joke from a Beautiful Woman | 2012 | Actress | Mary Elizabeth Winstead |
| Smashed | 2012 | Actress | Kate Hannah |
| Magnificat | 2011 | Actress | Lynn |
| The Thing | 2011 | Actress | Kate Lloyd |
| Cost of Living | 2011 | Actress | The Computer (voice) |
| The Clash at Demonhead: Black Sheep | 2010 | Actress | Ramona Flowers |
| Scott Pilgrim vs. the World | 2010 | Actress | Ramona Flowers |
| Make It Happen | 2008 | Actress | Lauryn |
| Live Free or Die Hard | 2007 | Actress | Lucy |
| Death Proof | 2007 | Actress | Lee |
| Grindhouse | 2007 | Actress | Lee (segment "Death Proof") |
| Factory Girl | 2006 | Actress | Ingrid Superstar |
| Black Christmas | 2006 | Actress | Heather Fitzgerald |
| Bobby | 2006 | Actress | Susan |
| Final Destination 3 | 2006 | Actress | Wendy Christensen |
| Sky High | 2005 | Actress | Gwen |
| Checking Out | 2005 | Actress | Lisa Apple |
| The Ring Two | 2005 | Actress | Young Evelyn |
| Monster Island | 2004 | Actress | Maddy |
| Tru Calling | 2004 | Actress | Bridget Elkins |
| Then Came Jones | 2003 | Actress | Rina |
| Wolf Lake | 2001–2002 | Actress | Sophia Donner |
| Father Can't Cope | 2000 | Actress | Tara |
| Passions | 1999–2000 | Actress | Jessica Bennett |
| The Long Road Home | 1999 | Actress | Annie Jacobs |
| Promised Land | 1998 | Actress | Chloe |
| Touched by an Angel | 1997 | Actress | Kristy Cordis (uncredited) |
| Faults | 2014 | Producer | producer |
| The Cub | 2013 | Producer | executive producer |
| Magnificat | 2011 | Producer | executive producer |
| Money Monster | 2016 | Soundtrack | writer: "Da Da Da" |
| Long Way Home | 2025 | Self | Self |
| 82nd Golden Globe Awards | 2025 | Self | Self - Audience Member |
| Entertainment Tonight | 2023–2024 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2020–2024 | Self | Self |
| Awards Radar TV Series | 2023 | Self | Self |
| IMDb on the Scene | 2023 | Self | Self - Guest |
| Star Wars Celebration LIVE! 2023 | 2023 | Self | Self |
| Hollywood's Hard Hitters: Women in Action | 2023 | Self | Self |
| Hollywood Insider | 2019–2021 | Self | Self |
| Hollywood on Set | 2021 | Self | Self |
| Kate: Stunts Social Featurette Short | 2021 | Self | Self |
| The 73rd Primetime Emmy Awards | 2021 | Self | Self - Audience Member |
| The Late Late Show with James Corden | 2016–2021 | Self | Self - Guest |
| The Roles That Changed My Life | 2021 | Self | Self - Guest |
| Long Way Up | 2020 | Self | Self |
| Scott Pilgrim vs. the World Water Crisis | 2020 | Self | Self - Ramona Flowers |
| Harley Quinn & The Birds of Prey: Wild Nerds | 2020 | Self | Self |
| Celebrity Page | 2017–2020 | Self | Self |
| GMA3: What You Need to Know | 2020 | Self | Self |
| Hollywood First Look | 2020 | Self | Self |
| Harley Quinn: Birds of Prey - Triumph Featurette | 2020 | Self | Huntress |
| Tchi tcha | 2020 | Self | Self |
| The View | 2020 | Self | Self - Guest |
| Good Morning Britain | 2020 | Self | Self - 'Huntress' |
| The IMDb Show | 2019 | Self | Self - Guest |
| Collider Ladies Night | 2019 | Self | Self - Guest |
| Off Camera with Sam Jones | 2018 | Self | Self |
| Last Call with Carson Daly | 2015–2018 | Self | Self - Guest |
| Made in Hollywood | 2010–2018 | Self | Self |
| Vulture: YouTube Channel TV Series | 2018 | Self | Self |
| That One Audition Podcast Series | 2018 | Self | Self |
| The 23rd Annual Critics' Choice Awards | 2018 | Self | Self |
| IMDb Interviews | 2017 | Self | Self - Guest |
| Late Night with Seth Meyers | 2016–2017 | Self | Self - Guest |
| Hollywood Today Live | 2017 | Self | Self |
| The Making of '10 Cloverfield Lane' | 2016 | Self | Self |
| Live from the Red Carpet: The 2016 Tony Awards TV Special | 2016 | Self | Self |
| The 70th Annual Tony Awards | 2016 | Self | Self - Presenter |
| Broadway.com 2016 Tony Awards Special TV Special | 2016 | Self | Self |
| The Late Show with Stephen Colbert | 2016 | Self | Self - Guest |
| Talkhouse Podcast Podcast Series | 2016 | Self | Self - Guest |
| Drinking with the Stars | 2016 | Self | Self |
| StudioWrap TV Series | 2016 | Self | Self |
| Comedy Bang! Bang! | 2015 | Self | Self |
| LRM Online: YouTube Channel TV Series | 2015 | Self | Self - Guest |
| Reel Junkie | 2015 | Self | Self |
| Today | 2010–2014 | Self | Self - Guest |
| Showing Up | 2014 | Self | Self |
| The 2013 Film Independent Spirit Awards | 2013 | Self | Self - Nominee |
| Decoding Die Hard | 2013 | Self | Self |
| 70th Golden Globe Awards | 2013 | Self | Self (uncredited) |
| Esquire: YouTube Channel TV Mini Series | 2012 | Self | Self |
| Special Look | 2012 | Self | Self |
| Up Close with Carrie Keagan | 2007–2012 | Self | Self - Guest |
| The Thing Evolves | 2012 | Self | Self |
| Scream Awards 2011 | 2011 | Self | Self |
| Attack of the Show! | 2011 | Self | Self - Guest |
| The 68th Annual Golden Globe Awards | 2011 | Self | Self |
| The Making of 'Scott Pilgrim vs. the World' | 2010 | Self | Self |
| Janela Indiscreta | 2010 | Self | Self |
| Scott Pilgrim vs. The World vs. Funny or Die | 2010 | Self | Self |
| Jimmy Kimmel Live! | 2010 | Self | Self - Guest |
| Live Free or Die Hard Gag Reel | 2007 | Self | Self - Lucy McClane (uncredited) |
| Scream Awards 2007 | 2007 | Self | Self |
| Analog Hero in a Digital World: Making of 'Live Free or Die Hard' | 2007 | Self | Self |
| The Late Late Show with Craig Ferguson | 2007 | Self | Self - Guest |
| Guys Choice | 2007 | Self | Self |
| Bobby: The Making of an American Epic | 2007 | Self | Self |
| May All Your Christmases Be Black | 2007 | Self | Self |
| 13th Annual Screen Actors Guild Awards | 2007 | Self | Self - Nominee |
| What Have You Done?: The Remaking of 'Black Christmas' | 2006 | Self | Self |
| Scream Awards 2006 | 2006 | Self | Self |
| Kill Shot: The Making of 'FD3' | 2006 | Self | Self |
| Dead Teenager Movie | 2006 | Self | Self - Final Girl |
| Death's Design: Making 'Final Destination 3' | 2006 | Self | Self |
| Planned Accidents | 2006 | Self | Self |
| 2005 BAFTA/LA Cunard Britannia Awards | 2005 | Self | Self |
| Robot Head | 2023–2024 | Archive Footage | Self |
| Movie Night Extravaganza | 2024 | Archive Footage | Self (archive footage) |
| Heel vs Babyface | 2023 | Archive Footage | Hera Syndulla (archive footage) |
| Disparu | 2023 | Archive Footage | Self (archive footage) |
| The Tonight Show Starring Jimmy Fallon | 2020 | Archive Footage | Self (archive footage) |
| Cinemassacre's Monster Madness | 2014 | Archive Footage | Lee (archive footage) |
| Black Christmas: Deleted Scenes Video | 2006 | Archive Footage | Heather Fitzgerald (archive footage) |
| VH1 Legends | 1997 | Archive Footage | Self (archive footage, uncredited) |