| UCB Comedy Originals | 2013 | Director | Director |
| Beyonce as a Mommy TV Series | 2011 | Director | Director |
| Tyra Banks Exclusive 2010 Short | 2010 | Director | Director |
| Michelle Obama's Breaking Point Short | 2009 | Director | Director |
| The First Woman TV Special | 2023 | Writer | Writer |
| Sasheer Zamata: The First Woman | 2023 | Writer | Writer |
| Sasheer Zamata: Pizza Mind | 2017 | Writer | Writer |
| Pursuit of Sexiness | 2013–2015 | Writer | creator |
| This American Life: One Night Only at BAM | 2014 | Writer | Writer |
| UCB Comedy Originals | 2013–2014 | Writer | writer |
| Storytime TV Series | 2014 | Writer | Writer |
| Above Average Presents | 2013 | Writer | writer |
| Tie Short | 2013 | Writer | writer |
| Fodder | 2012–2013 | Writer | writer |
| Black Superheroes | 2013 | Writer | writer |
| Animated Stories | 2012 | Writer | story |
| Mos Def, Talib Kweli and a Mystery Man Share Calamari with Sasheer Zamata Short | 2012 | Writer | story |
| White Powder Short | 2012 | Writer | Writer |
| Subway Rush Short | 2011 | Writer | writer |
| Beyonce as a Mommy TV Series | 2011 | Writer | creator |
| Tyra Banks Exclusive 2010 Short | 2010 | Writer | writer |
| Michelle Obama's Breaking Point Short | 2009 | Writer | writer |
| Moon Girl and Devil Dinosaur | 2023–2025 | Actress | Adria |
| Agatha All Along | 2024 | Actress | Jennifer Kale |
| Exploding Kittens | 2024 | Actress | Devilcat (voice) |
| Moon Girl and Devil Dinosaur: Moon Girl's Lab | 2024 | Actress | Flying Fox (voice) |
| Unfrosted | 2024 | Actress | Beth Donovan |
| Significant Others | 2024 | Actress | |
| Waco: The Aftermath | 2023 | Actress | Angie Graham |
| Home Economics | 2021–2023 | Actress | Denise |
| Tuca & Bertie | 2021–2022 | Actress | Kara (voice) |
| Woke | 2020–2022 | Actress | Ayana |
| The Fungies | 2020–2021 | Actress | Mama Lemon |
| Dog Cop 7: The Final Chapter | 2021 | Actress | Detective Jade |
| Grand Crew | 2021 | Actress | Gloria |
| Muppets Haunted Mansion | 2021 | Actress | Ghost of Mary |
| Operation Cordelia Podcast Series | 2021 | Actress | Tracy |
| The Mitchells vs. the Machines | 2021 | Actress | Jade (voice) |
| The Pole | 2021 | Actress | Helenor (voice) |
| The Big Day Short | 2020 | Actress | Bride |
| Comedy Bang Bang: The Podcast | 2020 | Actress | Tyler Wiffle |
| The Last O.G. | 2020 | Actress | Isis |
| Robbie | 2020 | Actress | Ava |
| Spree | 2020 | Actress | Jessie Adams |
| NBA 2K20 | 2019 | Actress | PR Chief (voice) |
| Historical Roasts | 2019 | Actress | Rosa Parks |
| Corporate | 2019 | Actress | Jessica |
| This Giant Beast That is the Global Economy | 2019 | Actress | Guest Star |
| Overthinking with Kat & June | 2018 | Actress | Tiff |
| So Close | 2018 | Actress | Riley |
| The Weekend | 2018 | Actress | Zadie Barber |
| Night Train with Wyatt Cenac | 2018 | Actress | The Ghost of Shirley Chisholm |
| I Feel Pretty | 2018 | Actress | Tasha |
| *Loosely Exactly Nicole | 2017–2018 | Actress | Kim |
| The Special Without Brett Davis | 2017 | Actress | |
| At Home with Amy Sedaris | 2017 | Actress | Ms. Stern |
| The Outdoorsman | 2017 | Actress | Mona |
| Who Is? | 2017 | Actress | (voice) |
| Mission to Zyxx | 2017 | Actress | Shataina the Fairy Princess |
| BoJack Horseman | 2017 | Actress | Jewelry Store Clerk (voice) |
| Sasheer Zamata Party Time TV Series | 2017 | Actress | |
| Saturday Night Live | 2014–2017 | Actress | Various |
| Saturday Night Live: Cut for Time | 2014–2017 | Actress | Rachel Lindsay |
| Deidra & Laney Rob a Train | 2017 | Actress | Ms. Spencer |
| Albert | 2016 | Actress | Maisie (voice) |
| People of Earth | 2016 | Actress | Marcy |
| Call of Duty: Infinite Warfare | 2016 | Actress | Sally (Zombies in Spaceland) (voice) |
| Transparent | 2016 | Actress | Asra |
| Yoga Hosers | 2016 | Actress | Principal Invincible |
| Sleight | 2016 | Actress | Georgi |
| Pursuit of Sexiness | 2013–2015 | Actress | Sheer |
| UCB Comedy Originals | 2013–2015 | Actress | Sheer |
| Prom Queen | 2015 | Actress | Teacher #2 |
| Dropout | 2012–2015 | Actress | Sasheer |
| Lucas Bros Moving Co | 2015 | Actress | Blackneficent (voice) |
| The Jay Z Story | 2015 | Actress | Beyonce Knowles |
| The Re-Gift | 2014 | Actress | ACE Party Girl |
| Grow a Guy | 2014 | Actress | Friend |
| Inside Amy Schumer | 2013–2014 | Actress | Tess |
| The Crumb of It | 2014 | Actress | Sasheer |
| Intimate Semaphores | 2014 | Actress | Sasheer (segment "Cake") |
| Life's Great TV Series | 2014 | Actress | Fake Susan |
| Clench and Release TV Series | 2014 | Actress | Angela |
| Dream Jobs TV Series | 2014 | Actress | Madison |
| Little Horribles Short | 2013 | Actress | |
| Above Average Presents | 2013 | Actress | Female Biker |
| PITtv | 2013 | Actress | Mom |
| Tie Short | 2013 | Actress | |
| You Look Familiar Short | 2013 | Actress | |
| Thingstarter TV Series | 2013 | Actress | Woman on Street |
| Fodder | 2012–2013 | Actress | Various |
| The Morning After | 2013 | Actress | |
| Srsly X Glamour TV Series | 2013 | Actress | |
| Black Superheroes | 2013 | Actress | |
| Three to One Short | 2012 | Actress | |
| UCB Live! TV Series | 2012–2014 | Actress | |
| The Scarf Short | 2012 | Actress | |
| White Powder Short | 2012 | Actress | |
| Jest Originals | 2011–2012 | Actress | Blue Ivy |
| Subway Rush Short | 2011 | Actress | |
| Beyonce as a Mommy TV Series | 2011 | Actress | Beyonce |
| Acid Tests | 2010 | Actress | Karen |
| Tyra Banks Exclusive 2010 Short | 2010 | Actress | Tyra Banks |
| Michelle Obama's Breaking Point Short | 2009 | Actress | Michelle Obama |
| Sticks and Stones Short | 2005 | Actress | (as Sasheer Moore) |
| Sasheer Zamata: The First Woman | 2023 | Producer | executive producer |
| Sasheer Zamata: Pizza Mind | 2017 | Producer | executive producer |
| Tie Short | 2013 | Producer | executive producer |
| Subway Rush Short | 2011 | Producer | executive producer |
| Beyonce as a Mommy TV Series | 2011 | Producer | executive producer |
| Tyra Banks Exclusive 2010 Short | 2010 | Producer | executive producer |
| Michelle Obama's Breaking Point Short | 2009 | Producer | executive producer |
| Subway Rush Short | 2011 | Editor | Editor |
| Saturday Night Live | 2015 | Camera and Electrical Department | camera |
| Spree | 2020 | Additional Crew | additional photographs & videos |
| Agatha All Along | 2024 | Soundtrack | performer: "The Ballad of the Witches' Road (Agatha Through Time Version)" |
| Saturday Night Live | 2014–2016 | Soundtrack | performer: "Melainianade" |
| After Midnight | 2024–2025 | Self | Self |
| The 31st Annual Screen Actors Guild Awards | 2025 | Self | Self - Audience Member |
| CNN New Year's Eve Live with Anderson Cooper & Andy Cohen TV Special | 2024 | Self | Self - Guest |
| Is It Cake? Holiday | 2024 | Self | Self - Judge |
| Marvel Studios: Assembled | 2024 | Self | Self - Jennifer Kale |
| The Talk | 2017–2024 | Self | Self |
| The Daily Show | 2024 | Self | Self - Guest |
| IMDb Interviews | 2024 | Self | Self - Guest |
| The Official Marvel Podcast | 2024 | Self | Self |
| Who Wants to Be a Millionaire | 2024 | Self | Self - Contestant |
| Made in Hollywood | 2022–2024 | Self | Self |
| Chrissy & Dave Dine Out | 2024 | Self | Self |
| The Big Flop | 2023 | Self | Self |
| The First Woman TV Special | 2023 | Self | Self |
| Sasheer Zamata: The First Woman | 2023 | Self | Self |
| Tamron Hall | 2021–2023 | Self | Self |
| Celebrity Wheel of Fortune | 2022 | Self | Self - Celebrity Contestant |
| The Wonderful World of Disney: Magical Holiday Celebration | 2022 | Self | Self - Well Wisher |
| Akesi and the Congo River Short | 2022 | Self | Self - Host |
| Celebrity Game Face | 2022 | Self | Self |
| Jimmy Kimmel Live! | 2022 | Self | Self - Guest |
| Celebrity Page | 2022 | Self | Self |
| The Kelly Clarkson Show | 2022 | Self | Self |
| GMA3: What You Need to Know | 2022 | Self | Self |
| Couples Therapy Podcast Series | 2018–2022 | Self | Self |
| Comedy Bang Bang: The Podcast | 2021 | Self | Self |
| Nailed It! | 2021 | Self | Self - Guest Judge |
| WTF with Marc Maron | 2021 | Self | Self - Guest |
| Entertainment Tonight | 2021 | Self | Self |
| Sloppy Seconds with Big Dipper & Meatball Podcast Series | 2021 | Self | Self - Guest |
| The George Lucas Talk Show | 2020 | Self | Self |
| CBC Winnipeg Comedy Festival | 2020 | Self | Self |
| The Stand-Up Show with Jon Dore TV Series | 2020 | Self | Self |
| Hollywood Game Night | 2018–2020 | Self | Self - Celebrity Player |
| Marvel's Storyboards | 2020 | Self | Self |
| 25 Words or Less | 2018–2020 | Self | Self - Contestant |
| Finding Your Roots with Henry Louis Gates, Jr. | 2020 | Self | Self - Guest |
| Christmas Magic | 2019 | Self | Self |
| Above Average Presents | 2019 | Self | Self |
| Best Friends with Nicole Byer and Sasheer Zamata | 2019 | Self | Self - Host |
| The New Negroes | 2019 | Self | Self - Comedian |
| The Fix | 2018 | Self | Self - Guest |
| StarTalk | 2017–2018 | Self | Self - Co-Host |
| To Tell the Truth | 2018 | Self | Self - Panelist |
| The Late Show with Stephen Colbert | 2018 | Self | Self - Guest Comic |
| Unapologetic with Aisha Tyler | 2018 | Self | Self |
| The Chris Gethard Show | 2018 | Self | Self |
| Dish Nation | 2018 | Self | Self |
| Modern Love Podcast Series | 2017 | Self | Self - Narrator |
| Way Past Your Bedtime TV Series | 2017 | Self | Self |
| The Guest List | 2017 | Self | Self |
| Sasheer Zamata Party Time TV Series | 2017 | Self | Self |
| The $100,000 Pyramid | 2017 | Self | Self - Celebrity Player |
| Match Game | 2017 | Self | Self - Celebrity Panelist |
| Stand for Rights | 2017 | Self | Self |
| Sasheer Zamata: Pizza Mind | 2017 | Self | Self |
| @midnight | 2017 | Self | Self |
| Last Week | 2017 | Self | Self |
| Night Train with Wyatt Cenac | 2016 | Self | Self |
| UCB Comedy Originals | 2012–2016 | Self | Self |
| Thank You, Del: The Story of the Del Close Marathon | 2016 | Self | Self |
| Two Beers In: A Tipsy Political Roundtable TV Series | 2016 | Self | Self |
| Inside Joke at Moontower TV Series | 2015 | Self | Self |
| Vice News | 2015 | Self | Self |
| Fodder: A Special TV Movie | 2015 | Self | Self |
| Saturday Night Live: 40th Anniversary Special | 2015 | Self | Self |
| Alec Baldwin's Love Ride | 2014 | Self | Self (2016) |
| The George Lucas Talk Show: Stage Show | 2014 | Self | Self |
| Night Late TV Series | 2014 | Self | Self |
| This American Life: One Night Only at BAM | 2014 | Self | Self |
| What We Wasted Our Year On TV Special | 2013 | Self | Self - Water Cooler Correspondent |
| Hey Girl TV Series | 2013 | Self | Self |
| The Business of Comedy | 2013 | Self | Self |
| Primetime: Would You Fall for That? TV Series | 2013 | Self | Self - Co-host |
| On the Cusp, Off the Cuff | 2012 | Self | Self |
| Animated Stories | 2012 | Self | Self |
| Mos Def, Talib Kweli and a Mystery Man Share Calamari with Sasheer Zamata Short | 2012 | Self | Self |
| Storytime TV Series | 2010 | Self | Self |
| ComicArtistPro Secrets | 2024 | Archive Footage | Self (archive footage) |
| ABC News Breakfast | 2024 | Archive Footage | Self - Actor |
| A Saturday Night Live Mother's Day | 2020 | Archive Footage | Self |
| Saturday Night Live Christmas Special | 2019 | Archive Footage | Christmas Candle receiver (archive footage, uncredited) |
| Live from New York! | 2015 | Archive Footage | Self (archive footage, uncredited) |
| An SNL Valentine | 2015 | Archive Footage | Various (archive footage) |