| One Tree Hill | 2009–2012 | Director | Director |
| Grey's Anatomy | 2024–2025 | Actress | Dr. Cass Beckman |
| Freedom Hair | 2024 | Actress | Dana Berliner |
| Junction | 2024 | Actress | Allison |
| Deborah | 2022 | Actress | Nora |
| Love, Victor | 2020–2022 | Actress | Veronica |
| Good Sam | 2022 | Actress | Dr. Sam Griffith |
| False Positive | 2021 | Actress | Corgan |
| Hard Luck Love Song | 2020 | Actress | Carla |
| This Is Us | 2020 | Actress | Lizzy |
| Surveillance | 2019 | Actress | Maddy |
| Drunk History | 2019 | Actress | Bonnie Raines |
| Jane the Virgin | 2019 | Actress | Julie |
| Easy | 2019 | Actress | Alexandria |
| LEGO The Incredibles | 2018 | Actress | Voyd (voice) |
| Incredibles 2 | 2018 | Actress | Voyd (voice) |
| Alex, Inc. | 2018 | Actress | Vanessa Stanhope |
| Acts of Violence | 2018 | Actress | Detective Brooke Baker |
| Marshall | 2017 | Actress | Jen at the Bar |
| Chicago P.D. | 2014–2017 | Actress | Erin Lindsay |
| Chicago Justice | 2017 | Actress | Erin Lindsay |
| Chicago Med | 2015–2017 | Actress | Erin Lindsay |
| Chicago Fire | 2013–2017 | Actress | Erin Lindsay |
| Law & Order: Special Victims Unit | 2014–2016 | Actress | Erin Lindsay |
| HelLA | 2016 | Actress | Sophia |
| Pickle and Peanut | 2015 | Actress | Additional Voices (voice) |
| Hatfields & McCoys | 2013 | Actress | Emma McCoy |
| Partners | 2012–2013 | Actress | Ali Landow |
| One Tree Hill | 2003–2012 | Actress | Brooke Davis Baker |
| Mob Wives 2: The Christening | 2012 | Actress | Carla Facciolo |
| Mob Wives | 2011 | Actress | Carla Facciolo |
| Chalet Girl | 2011 | Actress | Chloe |
| Phineas and Ferb | 2011 | Actress | Sara (voice) |
| Southern Discomfort | 2010 | Actress | Haley |
| Table for Three | 2009 | Actress | Mary |
| The Narrows | 2008 | Actress | Kathy Popovich |
| The Hitcher | 2007 | Actress | Grace Andrews |
| Matt Willis: Hey Kid | 2006 | Actress | Sophia Bush |
| John Tucker Must Die | 2006 | Actress | Beth |
| Stay Alive | 2006 | Actress | October |
| Supercross | 2005 | Actress | Zoe Lang |
| The Flannerys | 2003 | Actress | Katie Flannery |
| Nip/Tuck | 2003 | Actress | Ridley Lange |
| Learning Curves | 2003 | Actress | Beth |
| Sabrina the Teenage Witch | 2003 | Actress | Fate Mackenzie |
| Point of Origin | 2002 | Actress | Carrie Orr |
| Van Wilder | 2002 | Actress | Sally |
| Junction | 2024 | Producer | co-producer |
| Another Body | 2023 | Producer | executive producer |
| Deborah | 2022 | Producer | executive producer |
| Good Sam | 2022 | Producer | producer |
| A Girl Named C | 2018 | Producer | executive producer |
| The Thousand Year Journey | 2015 | Producer | executive producer |
| One Tree Hill: Always & Forever | 2012 | Thanks | special thanks |
| The Hopeful | 2011 | Thanks | special thanks |
| One Tree Hill | 2005 | Soundtrack | performer: "For He's a Jolly Good Fellow" (uncredited) |
| Lego Masters | 2024 | Self | Self - Celebrity Contestant |
| Wicked Red Carpet TV Mini Series | 2024 | Self | Self |
| Morning Joe | 2024 | Self | Self |
| The Beat with Ari Melber | 2024 | Self | Self |
| Who Wants to Be a Millionaire | 2024 | Self | Self - Contestant |
| Lego Masters: Celebrity Holiday Bricktacular | 2024 | Self | Self - Guest |
| Work in Progress with Sophia Bush | 2019–2024 | Self | Self - Host |
| Live from Detroit: The Concert at Michigan Central | 2024 | Self | Self - Host |
| 2024 White House Correspondents Dinner | 2024 | Self | Self |
| Glamour: YouTube Channel TV Series | 2024 | Self | Self |
| Global Citizen Festival | 2023 | Self | Self |
| Celebrity Family Feud | 2023 | Self | Self - Contestant (as Sophia Bush Hughes) |
| 2023 White House Correspondents' Dinner | 2023 | Self | Self |
| The Daily Show | 2023 | Self | Self |
| I Weigh with Jameela Jamil | 2023 | Self | Self - Guest |
| Drama Queens | 2021–2022 | Self | Self - Host |
| 2022 White House Correspondents Association Dinner | 2022 | Self | Self |
| Celebrity Page | 2018–2022 | Self | Self |
| Entertainment Tonight | 2008–2022 | Self | Self |
| The Drew Barrymore Show | 2022 | Self | Self |
| The Late Show with Stephen Colbert | 2015 | Self | Self - Guest |
| Live with Kelly and Mark | 2007–2022 | Self | Self - Guest |
| Literally! with Rob Lowe | 2022 | Self | Self |
| CBS Mornings | 2022 | Self | Self |
| The Late Late Show with James Corden | 2022 | Self | Self |
| The Talk | 2022 | Self | Self |
| Unqualified | 2018–2021 | Self | Self - Guest |
| Made in Hollywood | 2021 | Self | Self |
| The 73rd Primetime Emmy Awards | 2021 | Self | Self - Presenter |
| Inside of You with Michael Rosenbaum | 2021 | Self | Self |
| Red Carpet Report | 2016–2021 | Self | Self |
| Today | 2015–2021 | Self | Self - Guest |
| Recipe for Change | 2021 | Self | Self |
| Stonewall Inn Safe Spaces Concert | 2021 | Self | Self |
| The Man Who Walked Around the World | 2020 | Self | Self - Interviewee |
| Telethon for America 2020 | 2020 | Self | Self |
| Cheat Sheet for the Voting Booth TV Series | 2020 | Self | Self - Guest |
| Jay Leno's Garage | 2020 | Self | Self - TV Host |
| Friday Night in with the Morgans | 2020 | Self | Self - Guest |
| Humpday with Hampshire | 2020 | Self | Self |
| 2020 Golden Globe Awards | 2020 | Self | Self (uncredited) |
| Beat Bobby Flay | 2019 | Self | Self |
| The Tonight Show Starring Jimmy Fallon | 2014–2019 | Self | Self |
| The 25th Annual Screen Actors Guild Awards | 2019 | Self | Self |
| 2019 Golden Globe Awards | 2019 | Self | Self |
| Armchair Expert with Dax Shepard | 2018 | Self | Self |
| Telethon for America | 2018 | Self | Self |
| The Chew | 2015–2018 | Self | Self - Guest |
| Extra | 2014–2018 | Self | Self |
| Daily Pop | 2018 | Self | Self - Guest |
| Late Night with Seth Meyers | 2014–2017 | Self | Self |
| Entertainment Tonight Canada | 2017 | Self | Self |
| E! Live from the Red Carpet | 2016–2017 | Self | Self |
| The 23rd Annual Screen Actors Guild Awards | 2017 | Self | Self - Presenter |
| The Insider | 2016 | Self | Self |
| Rachael Ray | 2014–2016 | Self | Self |
| 2016 Golden Globe Arrivals Special | 2016 | Self | Self |
| 73rd Golden Globe Awards | 2016 | Self | Self - Presenter |
| Sophia Bush Sneaks Into Glamour HQ Video | 2015 | Self | Self |
| The Wendy Williams Show | 2010–2015 | Self | Self |
| Global Citizen Festival | 2015 | Self | Self |
| The Meredith Vieira Show | 2015 | Self | Self |
| The 21st Annual Screen Actors Guild Awards | 2015 | Self | Self (uncredited) |
| Steve Harvey | 2014 | Self | Self |
| The Late Late Show with Craig Ferguson | 2007–2014 | Self | Self |
| The Queen Latifah Show | 2014 | Self | Self |
| Good Day L.A. | 2014 | Self | Self |
| Young Hollywood | 2014 | Self | Self |
| MythBusters | 2014 | Self | Self - Princess Leia |
| Fashion News Live | 2008–2013 | Self | Self |
| 2013 Do Something Awards | 2013 | Self | Self - Host |
| 70th Golden Globe Awards | 2013 | Self | Self (uncredited) |
| Global Citizen Festival TV Special | 2012 | Self | Self |
| Paulilu Mixtape | 2012 | Self | Self |
| 2012 Do Something Awards | 2012 | Self | Self |
| The 26th Annual Genesis Awards | 2012 | Self | Self - Presenter |
| One Tree Hill: Always & Forever | 2012 | Self | Self |
| 2011 Do Something! Awards | 2011 | Self | Self |
| Chelsea Lately | 2011 | Self | Self - Guest |
| Behind the Scenes: One Tree Hill Season 7 | 2010 | Self | Self |
| The 67th Annual Golden Globe Awards | 2010 | Self | Self |
| The Bonnie Hunt Show | 2009 | Self | Self |
| Behind the Scenes: One Tree Hill Season 6 | 2009 | Self | Self |
| Three's a Crowd Video | 2009 | Self | Self |
| A Gaythering Storm | 2009 | Self | Self |
| Golden Globe Awards | 2009 | Self | Self |
| 2007 Vail Film Festival Short | 2008 | Self | Self |
| Late Night with Conan O'Brien | 2006–2008 | Self | Self - Guest |
| The Teen Choice Awards 2008 | 2008 | Self | Self - Presenter |
| ESPY Awards | 2008 | Self | Self - Presenter |
| Behind the Scenes: One Tree Hill Season 5 | 2008 | Self | Self |
| 14th Annual Screen Actors Guild Awards | 2008 | Self | Self |
| The Teen Choice Awards 2007 | 2007 | Self | Self - Winner |
| Behind the Scenes: One Tree Hill Season 4 | 2007 | Self | |
| Up Close with Carrie Keagan | 2007 | Self | Self |
| The 12th Annual Critics' Choice Awards | 2007 | Self | Self |
| Jimmy Kimmel Live! | 2007 | Self | Self |
| HypaSpace | 2007 | Self | Self |
| John Tucker Must Die: Featurettes | 2006 | Self | Self |
| Kodiak Yearbook | 2006 | Self | Self |
| Grrrl Power | 2006 | Self | Self |
| Fashion Rocks | 2006 | Self | Self |
| The Teen Choice Awards 2006 | 2006 | Self | Self - Presenter |
| Punk'd | 2005 | Self | Self |
| Movie Life: House of Wax | 2005 | Self | Self |
| Late Show with David Letterman | 2005 | Self | Self |
| The 10th Annual Critics' Choice Awards | 2005 | Self | Self |
| Total Request Live | 2004 | Self | Self |
| The Late Late Show with Craig Kilborn | 2004 | Self | Self |
| Entertainment Tonight | 2015–2023 | Archive Footage | Self (archive footage) |
| Live with Kelly and Mark | 2022 | Archive Footage | Self (archive footage) |
| FOX News Tonight | 2022 | Archive Footage | Self - Actress (archive footage) |
| Extra | 2015–2018 | Archive Footage | Self (archive footage) |
| Celebrity Page | 2017 | Archive Footage | Self (archive footage) |
| The Insider | 2016 | Archive Footage | Self (archive footage) |