| The Residence | 2025 | Actress | Cordelia Cupp |
| Greedy People | 2024 | Actress | Murphy |
| The Supremes at Earl's All-You-Can-Eat | 2024 | Actress | Clarice |
| Painkiller | 2023 | Actress | Edie Flowers |
| Lightyear | 2022 | Actress | Alisha Hawthorne (voice) |
| National Champions | 2021 | Actress | Katherine Poe |
| In Treatment | 2021 | Actress | Dr. Brooke Taylor |
| Solos | 2021 | Actress | Sasha |
| Really Love | 2020 | Actress | Chenai Hungwe |
| Mrs. America | 2020 | Actress | Shirley Chisholm |
| Steven Universe Future | 2020 | Actress | Bismuth |
| Miss Virginia | 2019 | Actress | Virginia Walden |
| Steven Universe: The Movie | 2019 | Actress | Bismuth (voice) |
| Orange Is the New Black | 2013–2019 | Actress | Suzanne 'Crazy Eyes' Warren |
| 3Below: Tales of Arcadia | 2018–2019 | Actress | Colonel Kubritz (voice) |
| Beats | 2019 | Actress | Carla Monroe |
| Steven Universe | 2016–2019 | Actress | Bismuth (voice) |
| Steven Universe and the Dove Self-Esteem Project | 2018 | Actress | Bismuth (voice) |
| We Are Boats | 2018 | Actress | Sir |
| Candy Jar | 2018 | Actress | Julia |
| Last Week Tonight with John Oliver | 2017 | Actress | Suzanne 'Crazy Eyes' Warren |
| My Little Pony: The Movie | 2017 | Actress | Queen Novo (voice) |
| Wally's Opening Day | 2017 | Actress | Francette |
| American Pastoral | 2016 | Actress | Vicky |
| Showing Roots | 2016 | Actress | Pearl |
| Tallulah | 2016 | Actress | Detective Kinnie |
| Alvin and the Chipmunks: The Road Chip | 2015 | Actress | TSA Officer |
| The Wiz Live! | 2015 | Actress | Glinda the Good Witch of the South |
| Verbatim: The Ferguson Case | 2015 | Actress | Sheila Whirley |
| Pearly Gates | 2015 | Actress | Corrie |
| Saturday Night Live | 2014 | Actress | Daughter Dudley (uncredited) |
| Leaked: Uzo Aduba's OITNB Audition Season 1 | 2014 | Actress | Uzo Aduba |
| How to Live Like a Lady TV Short | 2013 | Actress | Acting Teacher |
| Sing Along | 2013 | Actress | Cafeteria Lady |
| Blue Bloods | 2012 | Actress | Nurse |
| Wwjd | 2011 | Actress | Bartender |
| Over There Short | 2007 | Actress | |
| Notes | 2005 | Actress | |
| Slavery and the Making of America | 2005 | Actress | David Walker's Wife |
| Frimas | 2021 | Producer | executive producer |
| Steven Universe: The Movie | 2019 | Soundtrack | performer: "Who We Are", "Finale" |
| Steven Universe | 2018 | Soundtrack | performer: "Let's Only Think About Love" |
| The Wiz Live! | 2015 | Soundtrack | performer: "Believe in Yourself |
| Sing Along | 2013 | Soundtrack | performer: "Cafeteria Song" |
| The Kelly Clarkson Show | 2021–2025 | Self | Self - Guest |
| After Midnight | 2025 | Self | Self |
| The Jennifer Hudson Show | 2025 | Self | Self - Guest |
| Entertainment Tonight | 2014–2025 | Self | Self |
| Access Daily with Mario & Kit TV Series | 2025 | Self | Self - Guest |
| Live with Kelly and Mark | 2015–2025 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2021–2025 | Self | Self - Guest |
| CBS Mornings | 2025 | Self | Self - Guest |
| The Late Show with Stephen Colbert | 2016–2025 | Self | Self - Guest |
| Where Everybody Knows Your Name with Ted Danson and Woody Harrelson (Sometimes) | 2024 | Self | Self - Guest |
| The Talk | 2018–2024 | Self | Self - Guest |
| GMA3: What You Need to Know | 2024 | Self | Self - Guest |
| The View | 2015–2024 | Self | Self - Guest |
| Good Morning America | 2016–2024 | Self | Self - Guest |
| Conan O'Brien Needs a Friend | 2024 | Self | Self |
| The 30th Annual Screen Actors Guild Awards | 2024 | Self | Self - Nominee |
| Dinner's on Me with Jesse Tyler Ferguson Podcast Series | 2023 | Self | Self - Guest |
| The 76th Annual Tony Awards | 2023 | Self | Self - Presenter |
| This World Is Not My Own | 2023 | Self | Nellie Mae Rowe (voice) |
| Made in Hollywood | 2016–2022 | Self | Self |
| The Morning Show | 2022 | Self | Self - Guest |
| Today | 2014–2022 | Self | Self - Guest |
| The 75th Annual Tony Awards | 2022 | Self | Self - Nominee |
| The Broadway Show with Tamsen Fadal | 2021–2022 | Self | Self - Guest |
| Animal | 2022 | Self | Self - Narrator (voice) |
| Celebrity Page | 2017–2021 | Self | Self |
| The 73rd Primetime Emmy Awards | 2021 | Self | Self - Nominee & Presenter |
| Variety Studio: Actors on Actors | 2015–2021 | Self | Self |
| Talk Easy with Sam Fragoso | 2021 | Self | Self - Guest |
| Watch What Happens Live with Andy Cohen | 2021 | Self | Self - Guest |
| Access Hollywood | 2021 | Self | Self |
| Last Week Tonight with John Oliver | 2021 | Self | Self - Guest |
| Jimmy Kimmel Live! | 2021 | Self | Self - Guest |
| The Ellen DeGeneres Show | 2015–2021 | Self | Self - Guest |
| The 26th Annual Critics' Choice Awards | 2021 | Self | Self - Winner |
| The 72nd Primetime Emmy Awards | 2020 | Self | Self - Winner |
| Cari & Jemele (won't) Stick to Sports | 2020 | Self | Self - Guest |
| FX Networks: YouTube Channel TV Series | 2020 | Self | Self |
| OITNB X Color of Change: Reform, Solidarity, Action TV Special | 2020 | Self | Self |
| CBS News Sunday Morning with Jane Pauley | 2018–2020 | Self | Self - Guest |
| The Rosie O'Donnell Show: A Benefit for the Actors Fund | 2020 | Self | Self |
| Dennis Miller + One | 2020–2022 | Self | Self - Guest |
| Inside the Actors Studio | 2019 | Self | Self - Host |
| Activate: The Global Citizen Movement | 2019 | Self | Self |
| The 12th Annual CNN Heroes: An All-Star Tribute TV Special | 2018 | Self | Self - Presenter |
| The 2018 World Series | 2018 | Self | Self - Narrator |
| Off Camera with Sam Jones | 2018 | Self | Self |
| Larry King Now | 2018 | Self | Self - Guest |
| Konbini | 2018 | Self | Self - Guest |
| Dish Nation | 2018 | Self | Self |
| Running Wild with Bear Grylls | 2018 | Self | Self |
| The 72nd Annual Tony Awards | 2018 | Self | Self - Presenter |
| 2 Dope Queens | 2018 | Self | Self |
| The Chew | 2017 | Self | Self - Guest |
| The Making of My Little Pony: The Movie | 2017 | Self | Self |
| The 69th Primetime Emmy Awards | 2017 | Self | Self - Nominee |
| Hand in Hand: A Benefit for Hurricane Relief | 2017 | Self | Self |
| Emmy Quickie TV Series | 2017 | Self | Self |
| Lip Sync Battle | 2017 | Self | Self - Competitor |
| Lip Sync Battle Preshow | 2017 | Self | Self |
| C à vous | 2017 | Self | Self - Guest |
| Talking with Chris Hardwick | 2017 | Self | Self - Guest |
| American Pastoral: Adapting an American Classic | 2017 | Self | Self |
| Making the American Dream Video | 2017 | Self | Self |
| The 23rd Annual Screen Actors Guild Awards | 2017 | Self | Self - Winner |
| Chelsea | 2016 | Self | Self - Guest (as Uzo) |
| The Daily Show | 2016 | Self | Self - Guest |
| Variety Studio | 2016 | Self | Self |
| The 70th Annual Tony Awards | 2016 | Self | Self - Nominee |
| SAG Foundation Conversations | 2016 | Self | Self |
| 22nd Annual Screen Actors Guild Awards | 2016 | Self | Self - Winner |
| E! Live from the Red Carpet | 2016 | Self | Self |
| 73rd Golden Globe Awards | 2016 | Self | Self - Nominee |
| Taylor Swift: The 1989 World Tour Live | 2015 | Self | Self - Musical Guest |
| Late Night with Seth Meyers | 2014–2015 | Self | Self - Guest |
| Comedy Bang! Bang! | 2015 | Self | Self |
| The 67th Primetime Emmy Awards | 2015 | Self | Self - Winner |
| Conan | 2014–2015 | Self | Self - Guest |
| The Nightly Show with Larry Wilmore | 2015 | Self | Self - Panelist |
| CQC: Custe o Que Custar | 2015 | Self | Self |
| The Noite com Danilo Gentili | 2015 | Self | Self |
| Night of Too Many Stars: America Comes Together for Autism Programs | 2015 | Self | Self |
| The 46th Annual NAACP Image Awards | 2015 | Self | Self - Presenter |
| The 21st Annual Screen Actors Guild Awards | 2015 | Self | Self - Opening Remarks & Winner |
| 72nd Golden Globe Awards | 2015 | Self | Self - Nominee |
| The 8th Annual CNN Heroes: An All-Star Tribute TV Special | 2014 | Self | Self - Presenter |
| American Music Awards 2014 | 2014 | Self | Self - Presenter |
| Hell's Kitchen | 2014 | Self | Self - Restaurant Patron |
| The Insider | 2014 | Self | Self |
| The 66th Primetime Emmy Awards | 2014 | Self | Self - Presenter |
| 2014 Primetime Creative Arts Emmy Awards | 2014 | Self | Self - Presenter & Winner |
| 2014 MTV Video Music Awards | 2014 | Self | Self - Presenter |
| Kid President: Declaration of Awesome | 2014 | Self | Self - Guest |
| The Queen Latifah Show | 2014 | Self | Self - Guest |
| Chelsea Lately | 2014 | Self | Self - Guest |
| E! News | 2014 | Self | Self |
| The 4th Annual Critics' Choice Television Awards | 2014 | Self | Self |
| Black Girls Rock! 2013 | 2013 | Self | Self |
| Project Runway All Stars | 2012 | Self | Self - Godspell Cast |
| Entertainment Tonight | 2015–2025 | Archive Footage | Self (archive footage) |
| GMA3: What You Need to Know | 2024 | Archive Footage | Self (archive footage) |
| Morning Joe Weekend TV Series | 2024 | Archive Footage | Self |
| Live with Kelly and Mark | 2018–2021 | Archive Footage | Self (archive footage) |
| Extra | 2015 | Archive Footage | Self (archive footage) |
| Dinner's on Me with Jesse Tyler Ferguson Podcast Series | 2023 | Archive Sound | Self - Guest (archive footage) |