| True Spirit | 2023 | Actress | Julie Watson |
| A Friend of the Family | 2022 | Actress | Mary Ann Broberg |
| A Bit of Light | 2022 | Actress | Ella |
| Modern Love | 2021 | Actress | Isabelle |
| American Underdog | 2021 | Actress | Brenda Meoni |
| Flack | 2019–2020 | Actress | Robyn |
| The Affair | 2019 | Actress | Joanie Lockhart |
| The Irishman | 2019 | Actress | Older Peggy Sheeran |
| Tell It to the Bees | 2018 | Actress | Dr. Jean Markham |
| The Parting Glass | 2018 | Actress | Colleen |
| Furlough | 2018 | Actress | Lily Benson |
| Alias Grace | 2017 | Actress | Nancy Montgomery |
| Electric Dreams | 2017 | Actress | Sarah |
| Bellevue | 2017 | Actress | Annie Ryder |
| Broken | 2016 | Actress | Gemma |
| Roots | 2016 | Actress | Nancy Holt |
| The Good Dinosaur | 2015 | Actress | Ramsey (voice) |
| True Blood | 2008–2014 | Actress | Sookie Stackhouse |
| X-Men: Days of Future Past | 2014 | Actress | Rogue |
| Free Ride | 2013 | Actress | Christina |
| Susanna | 2013 | Actress | Katie |
| Straight A's | 2013 | Actress | Katherine |
| The Carrier | 2012 | Actress | Kim |
| Phineas and Ferb | 2011 | Actress | Kristen (voice) |
| Margaret | 2011 | Actress | Lisa Cohen |
| Scream 4 | 2011 | Actress | Rachel |
| True Blood: Webisodes | 2010 | Actress | Sookie Stackhouse |
| Open House | 2010 | Actress | Jennie |
| The Romantics | 2010 | Actress | Lila Hayes |
| The Courageous Heart of Irena Sendler | 2009 | Actress | Irena Sendler |
| Trick 'r Treat | 2007 | Actress | Laurie |
| Bury My Heart at Wounded Knee | 2007 | Actress | Elaine Goodale |
| Blue State | 2007 | Actress | Chloe Hamon |
| Mosaic | 2007 | Actress | Maggie (voice) |
| X-Men: The Last Stand | 2006 | Actress | Marie |
| Joan of Arc | 2005 | Actress | Joan (voice) |
| The Squid and the Whale | 2005 | Actress | Lili |
| Steamboy | 2004 | Actress | James Ray Steam (English version, voice) |
| X2: X-Men United | 2003 | Actress | Rogue |
| 25th Hour | 2002 | Actress | Mary D'Annuzio |
| Darkness | 2002 | Actress | Regina |
| Buffalo Soldiers | 2001 | Actress | Robyn Lee |
| Finding Forrester | 2000 | Actress | Claire |
| Almost Famous | 2000 | Actress | Polexia Aphrodisia |
| X-Men | 2000 | Actress | Rogue |
| All the Rage | 1999 | Actress | Annabel Lee |
| A Walk on the Moon | 1999 | Actress | Alison Kantrowitz |
| She's All That | 1999 | Actress | Mackenzie Siler |
| Hurlyburly | 1998 | Actress | Donna |
| Amistad | 1997 | Actress | Queen Isabella |
| The Member of the Wedding | 1997 | Actress | Frankie Addams |
| Fly Away Home | 1996 | Actress | Amy Alden |
| Jane Eyre | 1996 | Actress | Young Jane Eyre |
| The Piano | 1993 | Actress | Flora McGrath |
| Castle in the Sky | 1986 | Actress | Sheeta (Disney dub) (English version, voice) |
| A Bit of Light | 2022 | Producer | producer |
| Flack | 2019–2020 | Producer | executive producer |
| The Parting Glass | 2018 | Producer | producer |
| Bellevue | 2017 | Producer | executive producer |
| Civilianaire Boys' Club Short | 2015 | Producer | executive producer |
| Free Ride | 2013 | Producer | producer |
| Blue State | 2007 | Producer | executive producer |
| X-Men Mondays | 2018 | Thanks | special thanks |
| A Friend of the Family | 2022 | Soundtrack | performer: "Happy Birthday to You" |
| The Member of the Wedding | 1997 | Soundtrack | performer: "His Eye is on the Sparrow" |
| The Piano | 1993 | Soundtrack | performer: "The Grand Old Duke of York", "The Flowers of the Forest", "Barbara Allen" (uncredited) |
| Entertainment Tonight | 1996–2024 | Self | Self |
| A Friend of the Family: True Evil | 2022 | Self | Mary Ann Broberg |
| Hollywood Insider | 2020–2022 | Self | Self |
| Made in Hollywood | 2015–2021 | Self | Self |
| Today | 2021 | Self | Self - Guest |
| Making 'The Irishman': A Martin Scorsese Picture | 2020 | Self | Self |
| The 26th Annual Screen Actors Guild Awards | 2020 | Self | Self - Nominee & Presenter |
| 2020 Golden Globe Awards | 2020 | Self | Self (uncredited) |
| Pop Culture Weekly with Kyle Mcmahon TV Series | 2019 | Self | Self |
| The IMDb Show | 2019 | Self | Self - Guest |
| Couch Surfing TV Series | 2019 | Self | Self |
| Red Carpet Report | 2019 | Self | Self |
| GMA3: What You Need to Know | 2019 | Self | Self |
| Live with Kelly and Mark | 2004–2019 | Self | Self |
| The 24th Annual Critics' Choice Awards | 2019 | Self | Self |
| Last Call with Carson Daly | 2002–2018 | Self | Self |
| Conan | 2018 | Self | Self - Guest |
| WGN Morning News | 2018 | Self | Self |
| Celebrity Page | 2017–2018 | Self | Self |
| Roots: A New Vision | 2016 | Self | Nancy Holt |
| Roots: A History Revealed | 2016 | Self | Nancy Holt |
| Extra | 2014–2016 | Self | Self |
| The Late Late Show with James Corden | 2016 | Self | Self |
| Access Daily | 2015 | Self | Self |
| ScreenSlam | 2014–2015 | Self | Self |
| Mutant vs. Machine: The Making of 'X-Men: Days of Future Past' | 2015 | Self | Self |
| HuffPost Live Conversations | 2014 | Self | Self - Guest |
| Larry King Now | 2014 | Self | Self - Guest |
| Late Night with Seth Meyers | 2014 | Self | Self - Guest |
| HBO Boxing | 2012–2013 | Self | Self - Attendee |
| Jimmy Kimmel Live! | 2013 | Self | Self - Guest |
| The 63rd Primetime Emmy Awards | 2011 | Self | Self - Presenter |
| Scream Awards 2010 | 2010 | Self | Self |
| The 62nd Primetime Emmy Awards | 2010 | Self | Self - Presenter |
| Chelsea Lately | 2010 | Self | Self - Guest |
| Castle in the Sky: The World of Laputa | 2010 | Self | Self |
| Castle in the Sky: Creating 'Castle in the Sky' Video | 2010 | Self | Self |
| Castle in the Sky: Character Sketches Video | 2010 | Self | Self |
| 16th Annual Screen Actors Guild Awards | 2010 | Self | Self - Nominee |
| The 67th Annual Golden Globe Awards | 2010 | Self | Self - Nominee |
| The 36th Annual People's Choice Awards | 2010 | Self | Self |
| 2009 Golden Globe Awards Red Carpet Special | 2009 | Self | Self |
| Scream Awards 2009 | 2009 | Self | Self |
| The Graham Norton Show | 2009 | Self | Self - Guest |
| Late Night with Jimmy Fallon | 2009 | Self | Self - Guest |
| Late Show with David Letterman | 1996–2009 | Self | Self - Guest |
| Whatever Happened To? | 2009 | Self | Self |
| Séries express | 2009 | Self | Self |
| Golden Globe Awards | 2009 | Self | Self - Winner |
| Making True Blood TV Movie | 2008 | Self | Self |
| True Blood-Lines: A New Type | 2008 | Self | Self |
| Sidewalks Entertainment | 2008 | Self | Self |
| 14th Annual Screen Actors Guild Awards | 2008 | Self | Self |
| The 59th Annual Primetime Emmy Awards | 2007 | Self | Self |
| The 64th Annual Golden Globe Awards | 2007 | Self | Self |
| Casting Session | 2006 | Self | Self |
| X-Men Up Close | 2006 | Self | Self |
| The Making of 'X Men: The Last Stand' Blogs | 2006 | Self | Self |
| X-Men: The Excitement Continues | 2006 | Self | Self |
| X-Men: Evolution of a Trilogy | 2006 | Self | Self |
| The 60th Annual Tony Awards | 2006 | Self | Self - Presenter |
| Corazón de... | 2006 | Self | Self |
| HypaSpace | 2006 | Self | Self |
| The Late Late Show with Craig Ferguson | 2006 | Self | Self - Guest |
| Le grand journal de Canal+ | 2006 | Self | Self |
| The 58th Annual Tony Awards | 2004 | Self | Self - Presenter |
| X2 Global Webcast Highlights | 2003 | Self | Self |
| The Second Uncanny Issue of X-Men! Making 'X2' | 2003 | Self | Self |
| The Teen Choice Awards 2003 | 2003 | Self | Self |
| Late Night with Conan O'Brien | 1996–2003 | Self | Self - Guest |
| Spike Lee's '25th Hour': The Evolution of an American Filmmaker | 2003 | Self | Self |
| The View | 2003 | Self | Self - Guest |
| X-Men: Premieres Around the World | 2003 | Self | Self |
| X-Men: Ellis Island Premiere | 2003 | Self | Self |
| X-Factor: The Look of 'X-Men' | 2003 | Self | Self |
| The Visual Effects of X-Men | 2003 | Self | Self |
| The Uncanny Suspects | 2003 | Self | Self |
| X-Men Production Scrapbook | 2003 | Self | Self |
| The Daily Show | 2000–2002 | Self | Self - Guest |
| Liquid News | 2002 | Self | Self |
| Behind the Scenes: Finding Forrester | 2001 | Self | Self |
| Behind the Scenes: 'Almost Famous' - Postcards from the Road | 2001 | Self | Self |
| Breaking the Silence: The Making of 'Hannibal' | 2001 | Self | Self - N.Y. Premiere (uncredited) |
| 7th Annual Screen Actors Guild Awards | 2001 | Self | Self - Nominee |
| HBO First Look | 1996–2000 | Self | Self |
| X-Men: Behind the Scenes | 2000 | Self | Self |
| All Access: The Making of 'Almost Famous' | 2000 | Self | Self - 'Polexia' |
| 2000 Blockbuster Entertainment Awards | 2000 | Self | Self |
| The Rosie O'Donnell Show | 1999 | Self | Self - Guest |
| The Tonight Show with Jay Leno | 1999 | Self | Self - Guest |
| 5th Annual Screen Actors Guild Awards | 1999 | Self | Self |
| The 70th Annual Academy Awards | 1998 | Self | Self - Past Winner (uncredited) |
| The 67th Annual Academy Awards | 1995 | Self | Self - Presenter |
| The 66th Annual Academy Awards | 1994 | Self | Self - Winner |
| Entertainment Tonight | 2024 | Archive Footage | Self (archive footage) |
| Happy Pride! Sexy LGBT Stars | 2017 | Archive Footage | #14 - True Blood (archive footage) |
| The Oscars | 2017 | Archive Footage | Self (archive footage) |
| Superheroes Who Have Been Nude | 2016 | Archive Footage | #15 - True Blood (2008) (archive footage) |
| The Drunken Peasants | 2016 | Archive Footage | Self (archive footage) |
| Tellement Gay! Homosexualité et pop culture | 2015 | Archive Footage | Self (archive footage) |
| Chelsea Lately | 2012–2013 | Archive Footage | Sookie Stackhouse (archive footage) |
| True Blood: Webisodes | 2010 | Archive Footage | Sookie Stackhouse (archive footage) |
| Rocked the Nation TV Series | 2009 | Archive Footage | Self (archive footage) |
| The Graham Norton Show | 2009 | Archive Footage | Self (archive footage) |
| Premio Donostia a Ian McKellen | 2009 | Archive Footage | Marie |
| Oscar, que empiece el espectáculo | 2008 | Archive Footage | Flora McGrath (archive footage, uncredited) |
| Cinema mil | 2005 | Archive Footage | Regina (archive footage, uncredited) |
| 8th Annual Screen Actors Guild Awards | 2002 | Archive Footage | Self (archive footage) |