| High School | 2022 | Writer | based on the book 'High School' by |
| In the Know | 2024 | Actress | Guest Interviewee (as Tegan and Sara) |
| Tegan and Sara: I Can't Grow Up Music Video | 2022 | Actress | |
| Here & Queer | 2022 | Actress | |
| Tegan and Sara: I Know I'm Not the Only One Music Video | 2020 | Actress | Sara Quin |
| Take My Wife | 2018 | Actress | Sara |
| Song to Song | 2017 | Actress | Sara Quin |
| Tegan and Sara: Faint of Heart Music Video | 2016 | Actress | Sara Quin |
| Tegan and Sara: BWU | 2016 | Actress | Sara |
| Tegan and Sara: U-Turn Music Video | 2016 | Actress | Sara |
| Tegan & Sara: Stop Desire Music Video | 2016 | Actress | Artist |
| Night Terrors of 1927: When You Were Mine Music Video | 2014 | Actress | Singer (as Tegan and Sara) |
| Tegan and Sara: Goodbye, Goodbye Music Video | 2013 | Actress | Sara Quin |
| Tegan and Sara: I Was a Fool Music Video | 2013 | Actress | Sara Quin |
| Tegan and Sara: Closer | 2012 | Actress | Sara Quin |
| 90210 | 2012 | Actress | Sara Quin |
| Fanatical: The Catfishing of Tegan and Sara | 2024 | Producer | executive producer |
| High School | 2022 | Producer | executive producer |
| Get Along | 2011 | Producer | producer |
| The Intervention | 2016 | Composer | Composer |
| Chosen Ones Short | 2015 | Composer | Composer |
| Tegan and Sara: Goodbye, Goodbye Music Video | 2013 | Composer | Composer |
| Tegan and Sara: I Was a Fool Music Video | 2013 | Composer | Composer |
| Bridgit Mendler: I Was a Fool Music Video | 2013 | Composer | Composer |
| Tegan and Sara: Closer | 2012 | Composer | Composer |
| The Marvelous Mrs. Maisel | 2023 | Music Department | special performance by (as Tegan & Sara) |
| The Intervention | 2016 | Music Department | soundtrack |
| Night Terrors of 1927: When You Were Mine Music Video | 2014 | Music Department | vocals |
| The Masked Singer | 2024 | Soundtrack | writer: "Closer" |
| Crush | 2022 | Soundtrack | writer: "Faded Like a Feeling" |
| Happiest Season | 2020 | Soundtrack | writer: "Make You Mine This Season" |
| The New Mutants | 2020 | Soundtrack | writer: "Closer" |
| Teen Spirit | 2018 | Soundtrack | writer: "I Was A Fool" |
| The Package | 2018 | Soundtrack | writer: "Bad Ones" |
| To All the Boys I've Loved Before | 2018 | Soundtrack | writer: "Bad Ones" |
| Lean on Pete | 2017 | Soundtrack | writer: "Stop Desire" |
| Friends from College | 2017 | Soundtrack | writer: "Closer" |
| Riverdale | 2017 | Soundtrack | writer: "Boyfriend" (uncredited) |
| Grey's Anatomy | 2016 | Soundtrack | writer: "You Wouldn't Like Me" (uncredited) |
| The Tonight Show Starring Jimmy Fallon | 2016 | Soundtrack | writer: "Boyfriend" |
| The Intervention | 2016 | Soundtrack | producer: "Fade Out" |
| The Intern | 2015 | Soundtrack | writer: "Closer" |
| American Dad! | 2015 | Soundtrack | writer: "I Can't Take It" (uncredited) |
| The DUFF | 2015 | Soundtrack | writer: "How Come You Don't Want Me" |
| Night Terrors of 1927: When You Were Mine Music Video | 2014 | Soundtrack | performer: "When You Were Mine" |
| BoJack Horseman | 2014 | Soundtrack | writer: "Closer" (uncredited) |
| Young & Hungry | 2014 | Soundtrack | writer: "Closer" (uncredited) |
| G.B.F. | 2013 | Soundtrack | writer: "Body Work", "Closer" |
| The Tonight Show with Jay Leno | 2013 | Soundtrack | writer: "Closer" (uncredited) |
| Glee | 2013 | Soundtrack | writer: "Closer" (uncredited) |
| Girls | 2013 | Soundtrack | writer: "Sweetie" (uncredited) |
| Degrassi: The Next Generation | 2012 | Soundtrack | writer: "Closer " (uncredited) |
| 90210 | 2011 | Soundtrack | Soundtrack ("Why Even Try", uncredited) |
| Late Show with David Letterman | 2011 | Soundtrack | performer: "Why Even Try" (uncredited) |
| Being Erica | 2009–2010 | Soundtrack | writer: "Where Does the Good Go" |
| Altitude | 2010 | Soundtrack | writer: "Divided" |
| Rookie Blue | 2010 | Soundtrack | writer: "Hell" |
| Late Night with Conan O'Brien | 2007 | Soundtrack | lyrics: "Back in Your Head" |
| The 24th Day | 2004 | Soundtrack | writer: "Don't Confess" |
| What's New, Scooby-Doo? | 2003 | Soundtrack | writer: "Time Running" |
| Sweet November | 2001 | Soundtrack | writer: "My Number" |
| Good Morning America Weekend Edition | 2024 | Self | Self - Guest |
| Fanatical: The Catfishing of Tegan and Sara | 2024 | Self | Self - Musician |
| Canada's Drag Race | 2023 | Self | Self - Guest Judge |
| GMA3: What You Need to Know | 2023 | Self | Self |
| The JV Club with Janet Varney Podcast Series | 2023 | Self | Self - Guest |
| Here & Queer | 2022 | Self | Self |
| Mothership: The Documentary | 2020 | Self | Self |
| The Late Show with Stephen Colbert | 2019 | Self | Self - Tegan and Sara (as Sara) |
| Biography: I Want My MTV | 2019 | Self | Self |
| Sound it Out: The Untitled LGBTQIA Music Documentary | 2017 | Self | Self |
| This Just Out with Liz Feldman TV Series | 2009–2017 | Self | Self - Guest |
| Take My Wife | 2016 | Self | Self |
| Celebs React | 2016 | Self | Self |
| Comedy Bang! Bang! | 2016 | Self | Self |
| Good Morning America | 2016 | Self | Self - Tegan and Sara (uncredited) |
| The Oscars | 2015 | Self | Self - Tegan and Sara (uncredited) |
| Sound Advice | 2014 | Self | Self |
| Above Average Presents | 2014 | Self | Self |
| It Got Better | 2014 | Self | Self |
| MtvU Woodie Awards 2013 TV Special | 2013 | Self | Self - Host |
| Style Stage Short | 2013 | Self | Self |
| Big Morning Buzz Live | 2013 | Self | Self - Musical Guest |
| Tegan and Sara's Heartthrob: The Interviews | 2013 | Self | Self |
| Late Show with David Letterman | 2008–2012 | Self | Self |
| From Nothing, Something: A Documentary on the Creative Process | 2012 | Self | Self |
| Get Along | 2011 | Self | Self |
| Streetsmart TV Series | 2008 | Self | Self |
| NewNowNext Music TV Series | 2007 | Self | Self |
| Late Night with Conan O'Brien | 2005–2007 | Self | Self (as Tegan & Sara) |
| House Band | 2006 | Self | Self |
| Tegan and Sara: Live at the Phoenix | 2006 | Self | Self |
| Tegan and Sara: It's Not Fun. Don't Do It! | 2006 | Self | Self |
| It's Not Fun. Don't Do It!: Tegan and Sara on Tour | 2006 | Self | Self |
| The L Word | 2006 | Self | Self |
| New York Noise Presents: Summer in the City TV Mini Series | 2005 | Self | Self (as Sara & Tegan) |
| Live 8 | 2005 | Self | Self (as Sara) |
| The Making of 'So Jealous' | 2004 | Self | Self (uncredited) |
| Música sí | 2003 | Self | Self (as Tegan and Sara) |